Title:
Prostate Cancer: Shifting from Morphology to Biology edited by Stefania Staibano.
Main Entry:
Staibano, Stefania. editor.
SpringerLink (Online service)
Publisher:
Springer Netherlands : Imprint: Springer,
Publication Date:
2013.
Publication Place:
Dordrecht :
ISBN:
9789400771499
Subject:
Medicine.
Oncology.
Human genetics.
Gene expression.
Drug interactions.
Pathology.
Biomedicine.
Cancer research.
Human genetics.
Gene expression.
Drug resistance.
Pathology.
Oncology.
Contents:
Foreword. Preface. List of contributors. I Clues to morphological diagnosis and prognosis evaluation.-Update on diagnostic criteria, on biopsy and surgical specimen: pre-invasive lesions, from epithelial cell hyperplasia to carcinoma in situ invasive carcinoma. First-line immunophenotyping of prostate diseases -- II Molecular pathology -- Molecular determinants of cancer-related inflammation -- Apoptosis and autophagy -- Androgen receptor and steroidogenesis pathways -- Neuroendocrine differentiation – role of somatostatin receptors (SSTRs) for diagnosis, prognosis, and therapy -- Metastatic dissemination -- Resistance to castration - resistance to drugs -- Crossroads of signaling pathways. III Genetic and Epigenetic Events in prostate cancer -- Gene polymorphisms -- Expression signature -- Mapping prostate cancer aggressiveness loci -- Epigenetic mechanisms: histone acetylation, DNA methylation, miRNA, chromatin modifiers. IV A modern approach to therapy of prostate cancer: targeting the deadly subset.-Molecular markers for patient selection and stratification: personalized prognostic predictive models -- Targeting tumor angiogenesis -- Efficacy of signal transduction inhibition in advanced prostate cancer -- Therapeutic targeting of the bone pre-metastatic niche -- Counteracting hypoxia in radio-resistant metastatic lesions -- “Synthetic lethality”: molecular co-targeting to restore the DNA -- Repair mechanisms in prostate cancer cells concluding remarks. Index.
Related Records:
Springer eBooks
Printed edition: 9789400771482
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