Title:
The Structural Basis of Arrestin Functions edited by Vsevolod V. Gurevich.
Main Entry:
Gurevich, Vsevolod V. editor.
SpringerLink (Online service)
Publisher:
Springer International Publishing : Imprint: Springer,
Publication Date:
2017.
Publication Place:
Cham :
ISBN:
9783319575537
Subject:
Life sciences.
Biochemistry.
Proteins.
Life sciences.
Animal Biochemistry.
Protein Science.
Protein structure.
Contents:
Arrestins: discovery of the family and functional role of conformational flexibility -- Overview of arrestin-mediated signaling with receptors and non-receptor binding partners -- Initial crystallographic studies of visual arrestin: insights and perspectives -- Structural basis for b-arrestins in GPCR trafficking -- Arrestin-3: the structural basis of lower receptor selectivity -- Phosphate sensor and construction of phosphorylation-independent arrestins -- Comprehensive analysis of the role of arrestin residues in receptor binding -- How arrestin recognizes and binds active GPCRs -- Localization of conformational dynamics of arrestins by HDX-MS -- GPCR footprint on arrestins and manipulation of receptor specificity -- The structure of the polar core mutant R175E and its functional implications -- Active conformations of arrestins: expected and unexpected changes -- The arrestin-receptor complex: exciting answers and new questions -- Scaffolding c-Jun N-terminal kinase cascades: mechanistic insights from the reconstituted arrestin-JNK cascades -- Arrestin-dependent ERK activation and its disruption -- The functional role of the conformational changes in arrestin upon activation -- Is signaling specificity encoded in arrestin conformation? -- Monofunctional elements of multi-functional arrestin proteins -- Arrestins in cell death.
Related Records:
Springer eBooks
Printed edition: 9783319575520
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