Title:
Chemogenomics and Chemical Genetics A User's Introduction for Biologists, Chemists and Informaticians / edited by ERIC MARECHAL, Sylvaine Roy, Laurence Lafanechère.
Main Entry:
MARECHAL, ERIC.
Roy, Sylvaine.
Lafanechère, Laurence.
SpringerLink (Online service)
Publisher:
Springer Berlin Heidelberg : Imprint: Springer,
Publication Date:
2011.
Publication Place:
Berlin, Heidelberg :
ISBN:
9783642196157
Subject:
Chemistry.
Biotechnology.
Biochemistry.
Agriculture.
Bioinformatics.
Chemistry.
Medicinal Chemistry.
Computer Applications in Chemistry.
Bioinformatics.
Biotechnology.
Agriculture.
Contents:
<p>The pharmacological screening process:the small molecule, the biological target, the robot, the signal and the information -- Collections of molecules for screening: example of the French National Chemical Library -- The miniaturised biological assay: constraints and limitations -- The signal: statistical aspects, standardisation, elementary analysis -- Measuring bioactivity: Ki, IC50 and EC50 -- Modelling the pharmacological screening:controlling the processes and the chemical, biological and experimental information -- Quality procedures in automated screening -- Phenotypic screening of cells and the strategies for direct chemical genetics -- High information content screens for forward (phenotypic screening of organisms) and reverse (structural screening by NMR) chemical genetics -- Some principles of Diversity-Oriented Synthesis -- Molecular descriptors and similarity indices -- Lipophilicity of molecules: a predominant descriptor for QSAR -- The annotation and classification of chemical space in chemogenomics -- The annotation and classification of biological space in chemogenomics -- Machine learning and screening data -- Virtual screening by molecular docking -- Biodiversity as a source of small molecules for pharmacological screening: libraries of plant extracts.</p>.
Related Records:
Springer eBooks
Printed edition: 9783642196140
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