Title:
Introduction to biotechnology / William J. Thieman, Ventura College, Emeritus, Michael A. Palladino, Monmouth University.
Author:
Thieman, William J., author.
Palladino, Michael Angelo, author.
General Notes:
Includes bibliographical references and index.
Machine generated contents note: 1.1. What Is Biotechnology and What Does It Mean to You? -- A Brief History of Biotechnology -- The Do-It-Yourself Biotechnology Movement -- Biotechnology: A Science of Many Disciplines -- Products of Modern Biotechnology -- Ethics and Biotechnology -- 1.2. Types of Biotechnology -- Microbial Biotechnology -- Agricultural Biotechnology -- Animal Biotechnology -- Forensic Biotechnology -- Bioremediation -- Aquatic Biotechnology -- Medical Biotechnology -- Biotechnology Regulations -- The Biotechnology "Big Picture" -- 1.3. What Will the New Biotechnology Century Look Like? An Example from Medical Biotechnology -- A Scenario in the Future: How Might We Benefit from the Human Genome Project? -- 1.4. The Biotechnology Workforce -- The Business of Biotechnology -- Top Regions for Biotechnology Jobs in the United States -- What Is a Biotechnology Company? -- Jobs in Biotechnology -- Salaries in Biotechnology -- Hiring Trends in the Biotechnology Industry
Note continued: Questions & Activities -- 2.1.A Review of Cell Structure -- Prokaryotic Cells -- Eukaryotic Cells -- 2.2. The Molecule of Life -- DNA Structure -- What Is a Gene? -- 2.3. Chromosome Structure, DNA Replication, and Genomes -- Chromosome Structure -- 2.4. RNA and Protein Synthesis -- Copying the Code: Transcription -- Translating the Code: Protein Synthesis -- 2.5. Regulation of Gene Expression -- Transcriptional Regulation of Gene Expression -- Noncoding RNAs and Their Roles in Regulating Gene Expression -- Bacteria Use Operons to Regulate Gene Expression -- 2.6. Mutations: Causes and Consequences -- Types of Mutations -- Mutations Are the Basis of Variation in Genomes and a Cause of Human Genetic Diseases -- 2.7. Revealing the Epigenome -- 2.8. Immune Response Mechanism in Prokaryotes Results in Extraordinary New Technology for Editing Genes In Vitro and In Vivo -- Questions & Activities
Note continued: Case Study: Loss of Circular RNA Impacts miRNA Degradation and Brain Function -- 3.1. Introduction to Recombinant DNA Technology and DNA Cloning -- Restriction Enzymes and Plasmid DNA Vectors -- Transformation of Bacterial Cells and Antibiotic Selection of Recombinant Bacteria -- Introduction to Human Gene Cloning and Expressing Proteins for Biotechnology Applications -- What Makes a Good Vector? -- 3.2. How Do You Identify and Clone a Gene of Interest? -- DNA Libraries: Collections of Cloned Genes -- 3.3. Laboratory Techniques and Applications of Recombinant DNA Technology -- Agarose Gel Electrophoresis -- Restriction Mapping -- DNA Sequencing -- Next-Generation Sequencing (NGS) -- Third-Generation Sequencing Technology -- Fluorescence In Situ Hybridization -- Southern Blotting -- Studying Gene Expression -- Analyzing Gene Function -- 3.4. Genomics and Bioinformatics: The Hottest Disciplines in the History of Biotechnology -- Whole-Genome Sequencing
Note continued: Bioinformatics: Merging Molecular Biology with Computing Technology -- Examples of Bioinformatics in Action -- A Genome Cloning Effort of Epic Proportion: The Human Genome Project -- What Have We Learned from the Human Genome? -- Accessing Human Genome Information via the Internet -- The Human Genome Project Started an "Omics" Revolution -- After the HGP: What Is Next? -- 3.5. Systems Biology and Synthetic Biology -- Questions & Activities -- Case Study: The PANTHER Database -- 4.1. Proteins as Biotechnology Products -- Biotech Drugs and Other Medical Applications -- Bioremediation: Treating Pollution with Proteins -- 4.2. Protein Structures -- Structural Arrangement -- Protein-Protein Interaction Map Created -- Protein Folding -- Post-Translational Protein Modifications -- Protein Engineering by Directed Molecular Evolution -- 4.3. Protein Production -- Protein Expression: Upstream Processing -- Protein Purification Methods: Downstream Processing
Note continued: Verification -- Preserving Proteins -- Scaling Up Protein Purification -- Postpurification Analysis Methods -- 4.4. Proteomics -- Questions & Activities -- Case Study: Tau-Tau Protein Interaction in Alzheimer's Disease Study -- 5.1. The Structure of Microbes -- Yeasts Are Important Microbes, Too -- 5.2. Microorganisms as Tools -- Microbial Enzymes -- Bacterial Transformation -- Cloning and Expression Techniques -- 5.3. Using Microbes for a Variety of Everyday Applications -- Food Products -- Therapeutic Proteins -- Using Microbes against Other Microbes -- 5.4. Vaccines -- A Primer on Antibodies -- Types of Vaccines: How Are Vaccines Made? -- Major Targets for Vaccine Development -- 5.5. Microbial Genomics -- Why Sequence Microbial Genomes? -- Metagenomic Studies Sequence Genomes from Microbial Communities -- Viral Genomics -- Creating Synthetic Genomes -- 5.6. Microbial Diagnostics -- Detecting and Tracking Disease-Causing Microorganisms
Note continued: 5.7.Combating Bioterrorism -- Microbes as Bioweapons -- Targets of Bioterrorism -- Using Biotechnology against Bioweapons -- 5.8. Microbes for Making Biofuels -- Questions & Activities -- Case Study: Designer Microbes Rely on Synthetic Amino Acids -- 6.1. Uses of Biotechnology to Enhance Selective Breeding -- Marker-Assisted Selection -- Mutation Breeding -- Protoplast Fusion -- 6.2. Genetic Engineering of Plants -- Using Agrobacterium to Insert Genes -- The Leaf Fragment Technique -- Gene Guns -- Chloroplast Engineering -- Gene Inactivation Using CRISPR-Cas Technology -- Antisense Technology -- Gene Stacking -- 6.3. Practical Applications -- Protecting Plants from Viruses -- Genetic Pesticides -- Herbicide Resistance -- Enhanced Nutrition -- "Biopharming" -- Engineered Deletion of Gene Promoters Rather Than Genes -- 6.4. Health and Environmental Concerns -- Concerns about Human Health -- Concerns about the Environment -- Regulations
Note continued: Questions & Activities -- Case Study: Can RNA Interference Silence Genes in a Citrus Pest? -- 7.1. Animals in Research -- Why Use Animals in Research? -- Types of Animals Used in Research -- Regulations in Animal Research -- Alternatives to the Use of Animals -- Regulation of Animal Research -- Veterinary Medicine: Benefits for Humans and Animals -- 7.2. Cloning -- Creating Dolly: A Breakthrough in Cloning -- Limits to Cloning -- Human Organ Development in GM Animals -- 7.3. Transgenic Animals -- Transgenic Techniques -- GM Animals for the Agriculture Industry -- Transgenic Animals as Bioreactors -- Kidney on a Chip Determines Drug Dosing -- Gene Editing Technologies in Animals -- 7.4. Producing Human Antibodies in Animals -- Monoclonal Antibodies -- Questions & Activities -- Case Study: Using Zebrafish as a Heart Disease Model -- 8.1. What Is a DNA Fingerprint? -- How Is DNA Typing Performed? -- 8.2. Preparing a DNA Fingerprint -- Specimen Collection
Note continued: Extracting DNA for Analysis -- PCR and STR Analysis -- STR Analysis -- 8.3. Putting DNA to Use -- The Narborough Village Murder Case Led to a New Method of DNA Separation -- How Significant Is Contamination? -- World Events Lead to the Development of New Technologies -- 8.4. DNA and the Rules of Evidence -- DNA Fingerprinting and the Chain of Evidence -- Human Error and Sources of Contamination -- DNA Forensics from "Touch DNA" -- 8.5. Familial Relationships and DNA Profiles -- Mitochondrial DNA Analysis -- Y-Chromosome Analysis -- 8.6. Nonhuman DNA Analysis -- Identifying Plants through DNA -- Protein Analysis May Join DNA Forensics -- Animal DNA Analysis -- Food Fraud-A Recent DNA Forensics Application -- Genetically Modified Organism (GMO) Testing -- Questions & Activities -- Case Study: Mouse Cell Line Contamination ID Using DNA Forensics -- 9.1. What Is Bioremediation? -- Why Is Bioremediation Important? -- 9.2. Bioremediation Basics
Note continued: What Needs to Be Cleaned Up? -- Chemicals in the Environment -- Fundamentals of Cleanup Reactions -- The Players: Metabolizing Microbes -- Bioremediation Genomics Programs -- 9.3. Cleanup Sites and Strategies -- Soil Cleanup -- Bioremediation of Water -- 9.4. Turning Wastes into Energy -- 9.5. Applying Genetically Engineered Strains to Clean Up the Environment -- Petroleum-Eating Bacteria -- Engineering Microbes to Clean Up Heavy Metals -- Genetically Modified Plants and Phytoremediation -- Biosensors -- 9.6. Environmental Disasters: Case Studies in Bioremediation -- The Exxon Valdez Oil Spill -- Oil Fields of Kuwait -- The Deepwater Horizon Oil Spill -- 9.7. Challenges for Bioremediation -- Recovering Valuable Metals -- Bioremediation of Radioactive Wastes -- Degrading Macro-and Microplastics in the Environment -- Questions & Activities -- Case Study: Turning Outhouses into Lighthouses? -- 10.1. Introduction to Aquatic Biotechnology
Note continued: 10.2. Aquaculture: Increasing the World's Food Supply through Biotechnology -- The Economics of Aquaculture -- Fish-Farming Practices -- Improving Strains for Aquaculture -- Enhancing the Quality and Safety of Seafood -- Barriers and Limitations to Aquaculture -- 10.3. Genetic Technologies and Aquatic Organisms -- Analysis of Novel Genes from Aquatic Species -- Genetic Manipulations of Finfish and Shellfish -- 10.4. Medical Applications of Aquatic Biotechnology -- Bioprospecting to Isolate Medicines from the Sea -- 10.5. Nonmedical Products -- A Potpourri of Products -- Aquatic Biomass and Bioprocessing Applications -- 10.6. Environmental Applications of Aquatic Biotechnology -- Antifouling Agents -- Biosensors -- Environmental Remediation -- Questions & Activities -- Case Study: Massive Fish Escape Jeopardizes New Salmon Farm -- 11.1. Animal Models of Human Disease -- 11.2. Detecting and Diagnosing Human Disease Conditions
Note continued: Biomarkers for Disease Detection -- The Human Genome Project Revealed Disease Genes on All Human Chromosomes -- Genetic Testing: Detecting Chromosomal Abnormalities and Defective Genes -- 11.3. Sequence Analysis of Individual Genomes -- Whole-Exome Sequencing -- Genomic Analysis of Single Cells by DNA and RNA Sequencing -- Genome-Wide Association Studies Identify Genome Variations in Populations -- 11.4. Precision Medicine and Biotechnology -- What Is the Precision Medicine Initiative? -- Harnessing the Immune System for Treating Disease: Antibodies and Immunotherapy -- 11.5. Gene Therapy -- How Is It Done? -- Genome Editing Approaches for Gene Therapy -- Curing Genetic Diseases: Targets for Gene Therapy -- Challenges Facing Gene Therapy -- Future Challenges to Address -- 11.6. The Potential of Regenerative Medicine -- Cell and Tissue Transplantation -- Tissue Engineering -- Stem Cells -- Cloning -- Therapeutic Cloning and Reproductive Cloning
Note continued: Regulations Governing Embryonic Stem Cell and Therapeutic Cloning in the United States -- Questions & Activities -- Case Study: Personal Genomics Helps Elizabeth Davis Walk Again -- 12.1. The Regulatory Framework -- 12.2.U.S. Department of Agriculture -- Animal and Plant Health Inspection Service -- 12.3. The Environmental Protection Agency -- Experimental Use Permits -- Deregulation and Commercialization -- 12.4. The U.S. Food and Drug Administration -- Food and Food Additives -- The FDA Drug Approval Process -- The Development of Good Laboratory (GLP), Clinical (GCP), and Manufacturing (GMP) Practices -- Faster Drug Approval versus Public Safety -- FDA Regulations to Protect Laboratory Workers -- 12.5. Legislation and Regulation: The Ongoing Role of Government -- Who Watches the FDA's Regulations? -- 12.6. Introduction to Patents -- Obtaining a Patent -- The Value of Patents in the Biotechnology Industry -- 12.7. International Biotechnology Regulation
Note continued: The European Union -- Questions & Activities -- Case Study: How Should FDA Compliance Prevent a Product Recall at a Manufacturer? -- 13.1. What Is Ethics? -- Approaches to Ethical Decision Making -- Ethical Exercise Warm-Up -- 13.2. Examples of Ethics and Biotechnology -- Cells and Products -- GM Crops: Are You What You Eat? -- Animal Husbandry or Animal Tinkering? -- Synthetic Genomes and Synthetic Biology -- Drug Trials with Human Patients -- What Does It Mean to Be Human? -- Spare Embryos for Research versus Creating Embryos for Research -- Should Humans and Other Animals Be Cloned for Any Reason? -- Mitochondrial Replacement Therapy -- Patient Rights and Biological Materials -- Genetic Information and Genetic Privacy -- More or Less Human? -- Genome Editing and Germline Gene Modifications -- 13.3. Economics, the Role of Science, and Communication -- Questions & Activities -- Case Study: The GTEx Project, Cadavers, and Family Rights.
Publisher:
Pearson,
Publication Place:
NY, NY :
ISBN:
9780134650197
0134650190
Subject:
Biotechnology.
Biotechnology.
Edition:
Fourth edition.
Contents:
Machine generated contents note: 1.1. What Is Biotechnology and What Does It Mean to You? -- A Brief History of Biotechnology -- The Do-It-Yourself Biotechnology Movement -- Biotechnology: A Science of Many Disciplines -- Products of Modern Biotechnology -- Ethics and Biotechnology -- 1.2. Types of Biotechnology -- Microbial Biotechnology -- Agricultural Biotechnology -- Animal Biotechnology -- Forensic Biotechnology -- Bioremediation -- Aquatic Biotechnology -- Medical Biotechnology -- Biotechnology Regulations -- The Biotechnology "Big Picture" -- 1.3. What Will the New Biotechnology Century Look Like? An Example from Medical Biotechnology -- A Scenario in the Future: How Might We Benefit from the Human Genome Project? -- 1.4. The Biotechnology Workforce -- The Business of Biotechnology -- Top Regions for Biotechnology Jobs in the United States -- What Is a Biotechnology Company? -- Jobs in Biotechnology -- Salaries in Biotechnology -- Hiring Trends in the Biotechnology Industry
Note continued: Questions & Activities -- 2.1.A Review of Cell Structure -- Prokaryotic Cells -- Eukaryotic Cells -- 2.2. The Molecule of Life -- DNA Structure -- What Is a Gene? -- 2.3. Chromosome Structure, DNA Replication, and Genomes -- Chromosome Structure -- 2.4. RNA and Protein Synthesis -- Copying the Code: Transcription -- Translating the Code: Protein Synthesis -- 2.5. Regulation of Gene Expression -- Transcriptional Regulation of Gene Expression -- Noncoding RNAs and Their Roles in Regulating Gene Expression -- Bacteria Use Operons to Regulate Gene Expression -- 2.6. Mutations: Causes and Consequences -- Types of Mutations -- Mutations Are the Basis of Variation in Genomes and a Cause of Human Genetic Diseases -- 2.7. Revealing the Epigenome -- 2.8. Immune Response Mechanism in Prokaryotes Results in Extraordinary New Technology for Editing Genes In Vitro and In Vivo -- Questions & Activities
Note continued: Case Study: Loss of Circular RNA Impacts miRNA Degradation and Brain Function -- 3.1. Introduction to Recombinant DNA Technology and DNA Cloning -- Restriction Enzymes and Plasmid DNA Vectors -- Transformation of Bacterial Cells and Antibiotic Selection of Recombinant Bacteria -- Introduction to Human Gene Cloning and Expressing Proteins for Biotechnology Applications -- What Makes a Good Vector? -- 3.2. How Do You Identify and Clone a Gene of Interest? -- DNA Libraries: Collections of Cloned Genes -- 3.3. Laboratory Techniques and Applications of Recombinant DNA Technology -- Agarose Gel Electrophoresis -- Restriction Mapping -- DNA Sequencing -- Next-Generation Sequencing (NGS) -- Third-Generation Sequencing Technology -- Fluorescence In Situ Hybridization -- Southern Blotting -- Studying Gene Expression -- Analyzing Gene Function -- 3.4. Genomics and Bioinformatics: The Hottest Disciplines in the History of Biotechnology -- Whole-Genome Sequencing
Note continued: Bioinformatics: Merging Molecular Biology with Computing Technology -- Examples of Bioinformatics in Action -- A Genome Cloning Effort of Epic Proportion: The Human Genome Project -- What Have We Learned from the Human Genome? -- Accessing Human Genome Information via the Internet -- The Human Genome Project Started an "Omics" Revolution -- After the HGP: What Is Next? -- 3.5. Systems Biology and Synthetic Biology -- Questions & Activities -- Case Study: The PANTHER Database -- 4.1. Proteins as Biotechnology Products -- Biotech Drugs and Other Medical Applications -- Bioremediation: Treating Pollution with Proteins -- 4.2. Protein Structures -- Structural Arrangement -- Protein-Protein Interaction Map Created -- Protein Folding -- Post-Translational Protein Modifications -- Protein Engineering by Directed Molecular Evolution -- 4.3. Protein Production -- Protein Expression: Upstream Processing -- Protein Purification Methods: Downstream Processing
Note continued: Verification -- Preserving Proteins -- Scaling Up Protein Purification -- Postpurification Analysis Methods -- 4.4. Proteomics -- Questions & Activities -- Case Study: Tau-Tau Protein Interaction in Alzheimer's Disease Study -- 5.1. The Structure of Microbes -- Yeasts Are Important Microbes, Too -- 5.2. Microorganisms as Tools -- Microbial Enzymes -- Bacterial Transformation -- Cloning and Expression Techniques -- 5.3. Using Microbes for a Variety of Everyday Applications -- Food Products -- Therapeutic Proteins -- Using Microbes against Other Microbes -- 5.4. Vaccines -- A Primer on Antibodies -- Types of Vaccines: How Are Vaccines Made? -- Major Targets for Vaccine Development -- 5.5. Microbial Genomics -- Why Sequence Microbial Genomes? -- Metagenomic Studies Sequence Genomes from Microbial Communities -- Viral Genomics -- Creating Synthetic Genomes -- 5.6. Microbial Diagnostics -- Detecting and Tracking Disease-Causing Microorganisms
Note continued: 5.7.Combating Bioterrorism -- Microbes as Bioweapons -- Targets of Bioterrorism -- Using Biotechnology against Bioweapons -- 5.8. Microbes for Making Biofuels -- Questions & Activities -- Case Study: Designer Microbes Rely on Synthetic Amino Acids -- 6.1. Uses of Biotechnology to Enhance Selective Breeding -- Marker-Assisted Selection -- Mutation Breeding -- Protoplast Fusion -- 6.2. Genetic Engineering of Plants -- Using Agrobacterium to Insert Genes -- The Leaf Fragment Technique -- Gene Guns -- Chloroplast Engineering -- Gene Inactivation Using CRISPR-Cas Technology -- Antisense Technology -- Gene Stacking -- 6.3. Practical Applications -- Protecting Plants from Viruses -- Genetic Pesticides -- Herbicide Resistance -- Enhanced Nutrition -- "Biopharming" -- Engineered Deletion of Gene Promoters Rather Than Genes -- 6.4. Health and Environmental Concerns -- Concerns about Human Health -- Concerns about the Environment -- Regulations
Note continued: Questions & Activities -- Case Study: Can RNA Interference Silence Genes in a Citrus Pest? -- 7.1. Animals in Research -- Why Use Animals in Research? -- Types of Animals Used in Research -- Regulations in Animal Research -- Alternatives to the Use of Animals -- Regulation of Animal Research -- Veterinary Medicine: Benefits for Humans and Animals -- 7.2. Cloning -- Creating Dolly: A Breakthrough in Cloning -- Limits to Cloning -- Human Organ Development in GM Animals -- 7.3. Transgenic Animals -- Transgenic Techniques -- GM Animals for the Agriculture Industry -- Transgenic Animals as Bioreactors -- Kidney on a Chip Determines Drug Dosing -- Gene Editing Technologies in Animals -- 7.4. Producing Human Antibodies in Animals -- Monoclonal Antibodies -- Questions & Activities -- Case Study: Using Zebrafish as a Heart Disease Model -- 8.1. What Is a DNA Fingerprint? -- How Is DNA Typing Performed? -- 8.2. Preparing a DNA Fingerprint -- Specimen Collection
Note continued: Extracting DNA for Analysis -- PCR and STR Analysis -- STR Analysis -- 8.3. Putting DNA to Use -- The Narborough Village Murder Case Led to a New Method of DNA Separation -- How Significant Is Contamination? -- World Events Lead to the Development of New Technologies -- 8.4. DNA and the Rules of Evidence -- DNA Fingerprinting and the Chain of Evidence -- Human Error and Sources of Contamination -- DNA Forensics from "Touch DNA" -- 8.5. Familial Relationships and DNA Profiles -- Mitochondrial DNA Analysis -- Y-Chromosome Analysis -- 8.6. Nonhuman DNA Analysis -- Identifying Plants through DNA -- Protein Analysis May Join DNA Forensics -- Animal DNA Analysis -- Food Fraud-A Recent DNA Forensics Application -- Genetically Modified Organism (GMO) Testing -- Questions & Activities -- Case Study: Mouse Cell Line Contamination ID Using DNA Forensics -- 9.1. What Is Bioremediation? -- Why Is Bioremediation Important? -- 9.2. Bioremediation Basics
Note continued: What Needs to Be Cleaned Up? -- Chemicals in the Environment -- Fundamentals of Cleanup Reactions -- The Players: Metabolizing Microbes -- Bioremediation Genomics Programs -- 9.3. Cleanup Sites and Strategies -- Soil Cleanup -- Bioremediation of Water -- 9.4. Turning Wastes into Energy -- 9.5. Applying Genetically Engineered Strains to Clean Up the Environment -- Petroleum-Eating Bacteria -- Engineering Microbes to Clean Up Heavy Metals -- Genetically Modified Plants and Phytoremediation -- Biosensors -- 9.6. Environmental Disasters: Case Studies in Bioremediation -- The Exxon Valdez Oil Spill -- Oil Fields of Kuwait -- The Deepwater Horizon Oil Spill -- 9.7. Challenges for Bioremediation -- Recovering Valuable Metals -- Bioremediation of Radioactive Wastes -- Degrading Macro-and Microplastics in the Environment -- Questions & Activities -- Case Study: Turning Outhouses into Lighthouses? -- 10.1. Introduction to Aquatic Biotechnology
Note continued: 10.2. Aquaculture: Increasing the World's Food Supply through Biotechnology -- The Economics of Aquaculture -- Fish-Farming Practices -- Improving Strains for Aquaculture -- Enhancing the Quality and Safety of Seafood -- Barriers and Limitations to Aquaculture -- 10.3. Genetic Technologies and Aquatic Organisms -- Analysis of Novel Genes from Aquatic Species -- Genetic Manipulations of Finfish and Shellfish -- 10.4. Medical Applications of Aquatic Biotechnology -- Bioprospecting to Isolate Medicines from the Sea -- 10.5. Nonmedical Products -- A Potpourri of Products -- Aquatic Biomass and Bioprocessing Applications -- 10.6. Environmental Applications of Aquatic Biotechnology -- Antifouling Agents -- Biosensors -- Environmental Remediation -- Questions & Activities -- Case Study: Massive Fish Escape Jeopardizes New Salmon Farm -- 11.1. Animal Models of Human Disease -- 11.2. Detecting and Diagnosing Human Disease Conditions
Note continued: Biomarkers for Disease Detection -- The Human Genome Project Revealed Disease Genes on All Human Chromosomes -- Genetic Testing: Detecting Chromosomal Abnormalities and Defective Genes -- 11.3. Sequence Analysis of Individual Genomes -- Whole-Exome Sequencing -- Genomic Analysis of Single Cells by DNA and RNA Sequencing -- Genome-Wide Association Studies Identify Genome Variations in Populations -- 11.4. Precision Medicine and Biotechnology -- What Is the Precision Medicine Initiative? -- Harnessing the Immune System for Treating Disease: Antibodies and Immunotherapy -- 11.5. Gene Therapy -- How Is It Done? -- Genome Editing Approaches for Gene Therapy -- Curing Genetic Diseases: Targets for Gene Therapy -- Challenges Facing Gene Therapy -- Future Challenges to Address -- 11.6. The Potential of Regenerative Medicine -- Cell and Tissue Transplantation -- Tissue Engineering -- Stem Cells -- Cloning -- Therapeutic Cloning and Reproductive Cloning
Note continued: Regulations Governing Embryonic Stem Cell and Therapeutic Cloning in the United States -- Questions & Activities -- Case Study: Personal Genomics Helps Elizabeth Davis Walk Again -- 12.1. The Regulatory Framework -- 12.2.U.S. Department of Agriculture -- Animal and Plant Health Inspection Service -- 12.3. The Environmental Protection Agency -- Experimental Use Permits -- Deregulation and Commercialization -- 12.4. The U.S. Food and Drug Administration -- Food and Food Additives -- The FDA Drug Approval Process -- The Development of Good Laboratory (GLP), Clinical (GCP), and Manufacturing (GMP) Practices -- Faster Drug Approval versus Public Safety -- FDA Regulations to Protect Laboratory Workers -- 12.5. Legislation and Regulation: The Ongoing Role of Government -- Who Watches the FDA's Regulations? -- 12.6. Introduction to Patents -- Obtaining a Patent -- The Value of Patents in the Biotechnology Industry -- 12.7. International Biotechnology Regulation
Note continued: The European Union -- Questions & Activities -- Case Study: How Should FDA Compliance Prevent a Product Recall at a Manufacturer? -- 13.1. What Is Ethics? -- Approaches to Ethical Decision Making -- Ethical Exercise Warm-Up -- 13.2. Examples of Ethics and Biotechnology -- Cells and Products -- GM Crops: Are You What You Eat? -- Animal Husbandry or Animal Tinkering? -- Synthetic Genomes and Synthetic Biology -- Drug Trials with Human Patients -- What Does It Mean to Be Human? -- Spare Embryos for Research versus Creating Embryos for Research -- Should Humans and Other Animals Be Cloned for Any Reason? -- Mitochondrial Replacement Therapy -- Patient Rights and Biological Materials -- Genetic Information and Genetic Privacy -- More or Less Human? -- Genome Editing and Germline Gene Modifications -- 13.3. Economics, the Role of Science, and Communication -- Questions & Activities -- Case Study: The GTEx Project, Cadavers, and Family Rights.
Physical Description:
1 volume (various pagings) ;
Publication Date:
2019.
Title:
Introduction to Black Hole Astrophysics by Gustavo E. Romero, Gabriela S. Vila.
Lecture Notes in Physics,
Lecture notes in physics,
Author:
Romero, Gustavo E. author.
Vila, Gabriela S. author.
SpringerLink (Online service)
General Notes:
Space-time and Gravitation -- Black Holes -- Black Hole Physics -- Accretion onto Black Holes -- Jets -- Evidence for Black Holes -- Wormholes and Exotic Objects -- Black Holes and Cosmology -- Topology and Manifolds -- Selected and Annotated Bibliography.
This book is based on the lecture notes of a one-semester course on black hole astrophysics given by the author and is aimed at advanced undergraduate and graduate students with an interest in astrophysics. The material included goes beyond that found in classic textbooks and presents details on astrophysical manifestations of black holes. In particular, jet physics and detailed accounts of objects like microquasars, active galactic nuclei, gamma-ray bursts, and ultra-luminous X-ray sources are covered, as well as advanced topics like black holes in alternative theories of gravity. The author avoids unnecessary technicalities and to some degree the book is self-contained. The reader will find some basic general relativity tools in Chapter 1. The appendices provide some additional mathematical details that will be useful for further study, and a guide to the bibliography on the subject.
Publisher:
Springer Berlin Heidelberg : Imprint: Springer,
Publication Place:
Berlin, Heidelberg :
ISBN:
9783642395963
Subject:
Physics.
Gravitation.
Astrophysics.
Physics.
Astrophysics and Astroparticles.
Classical and Quantum Gravitation, Relativity Theory.
Series:
Lecture Notes in Physics, 876
Lecture notes in physics, 876
Contents:
Space-time and Gravitation -- Black Holes -- Black Hole Physics -- Accretion onto Black Holes -- Jets -- Evidence for Black Holes -- Wormholes and Exotic Objects -- Black Holes and Cosmology -- Topology and Manifolds -- Selected and Annotated Bibliography.
Physical Description:
XVIII, 318 p. 96 illus., 47 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-642-39596-3
Publication Date:
2014.
Title:
Introduction to Boolean Algebras by Paul Halmos, Steven Givant.
Undergraduate Texts in Mathematics,
Undergraduate texts in mathematics,
Author:
Halmos, Paul.
Givant, Steven.
SpringerLink (Online service)
General Notes:
Preface -- Boolean Rings -- Boolean Algebras -- Boolean Algebras versus Rings -- The Principle of Duality -- Fields of Sets -- Elementary Relations -- Order -- Infinite Operations -- Topology -- Regular Open Sets -- Subalgebras -- Homomorphisms -- Extensions of Homomorphisms -- Atoms -- Finite Boolean Algebras -- Atomless Boolean Algebras -- Congruences and Quotients -- Ideals and Filters -- Lattices of Ideals -- Maximal Ideals -- Homomorphism and Isomorphism Theorems -- The Representation Theorem -- Canonical Extensions -- Complete Homomorphisms and Complete Ideals -- Completions -- Products of Algebras -- Isomorphisms of Factors -- Free Algebras -- Boolean o-algebras -- The Countable Chain Condition -- Measure Algebras -- Boolean Spaces -- Continuous Functions -- Boolean Algebras and Boolean Spaces -- Duality for Ideals -- Duality for Homomorphisms.-Duality for Subalgebras -- Dualtiy for Completeness -- Boolean o-spaces -- The Representation of o-algebras -- Boolean Measure Spaces -- Incomplete Algebras -- Dualtiy for Products -- Sums of Algebras -- Isomorphisms of Countable Factors.-Epilogue -- Set Theory -- Hints to Selected Exercises -- References -- Index.
<P>In a bold and refreshingly informal style, this exciting text steers a middle course between elementary texts emphasizing connections with philosophy, logic, and electronic circuit design, and profound treatises aimed at advanced graduate students and professional mathematicians. It is written for readers who have studied at least two years of college-level mathematics. With carefully crafted prose, lucid explanations, and illuminating insights, it guides students to some of the deeper results of Boolean algebra --- and in particular to the important interconnections with topology --- without assuming a background in algebra, topology, and set theory. The parts of those subjects that are needed to understand the material are developed within the text itself.</P> <P> </P> <P>Highlights of the book include the normal form theorem; the homomorphism extension theorem; the isomorphism theorem for countable atomless Boolean algebras; the maximal ideal theorem; the celebrated Stone representation theorem; the existence and uniqueness theorems for canonical extensions and completions; Tarski’s isomorphism of factors theorem for countably complete Boolean algebras, and Hanf’s related counterexamples; and an extensive treatment of the algebraic-topological duality, including the duality between ideals and open sets, homomorphisms and continuous functions, subalgebras and quotient spaces, and direct products and Stone-Cech compactifications.</P> <P> </P> <P>A special feature of the book is the large number of exercises of varying levels of difficulty, from routine problems that help readers understand the basic definitions and theorems, to intermediate problems that extend or enrich material developed in the text, to harder problems that explore important ideas either not treated in the text, or that go substantially beyond its treatment. Hints for the solutions to the harder problems are given in an appendix. A detailed solutions manual for all exercises is available for instructors who adopt the text for a course.</P>
Publisher:
Springer New York,
Publication Place:
New York, NY :
ISBN:
9780387684369
Subject:
Mathematics.
Algebra.
Logic, Symbolic and mathematical.
Mathematics.
Order, Lattices, Ordered Algebraic Structures.
Mathematical Logic and Foundations.
Series:
Undergraduate Texts in Mathematics,
Undergraduate texts in mathematics,
Contents:
Preface -- Boolean Rings -- Boolean Algebras -- Boolean Algebras versus Rings -- The Principle of Duality -- Fields of Sets -- Elementary Relations -- Order -- Infinite Operations -- Topology -- Regular Open Sets -- Subalgebras -- Homomorphisms -- Extensions of Homomorphisms -- Atoms -- Finite Boolean Algebras -- Atomless Boolean Algebras -- Congruences and Quotients -- Ideals and Filters -- Lattices of Ideals -- Maximal Ideals -- Homomorphism and Isomorphism Theorems -- The Representation Theorem -- Canonical Extensions -- Complete Homomorphisms and Complete Ideals -- Completions -- Products of Algebras -- Isomorphisms of Factors -- Free Algebras -- Boolean o-algebras -- The Countable Chain Condition -- Measure Algebras -- Boolean Spaces -- Continuous Functions -- Boolean Algebras and Boolean Spaces -- Duality for Ideals -- Duality for Homomorphisms.-Duality for Subalgebras -- Dualtiy for Completeness -- Boolean o-spaces -- The Representation of o-algebras -- Boolean Measure Spaces -- Incomplete Algebras -- Dualtiy for Products -- Sums of Algebras -- Isomorphisms of Countable Factors.-Epilogue -- Set Theory -- Hints to Selected Exercises -- References -- Index.
Physical Description:
XIV, 574p. 10 illus. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-0-387-68436-9
Publication Date:
2009.
Title:
Introduction to brain-compatible learning / Eric Jensen. Brain-compatible learning
Brain-compatible learning Brain-compatible learning
Author:
Jensen, Eric, 1950-
General Notes:
Includes bibliographical references (p. 111-119) and index.
pt. 1. Background you need. -- What is brain-compatible teaching -- The old and new of it -- When brain research is applied to the classroom everything will change -- Change can be easy -- We're not in Kansas anymore -- Where's the proof -- Tools for exploring the brain -- Ten reasons to care about brain research -- The evolution of brain models -- Be a brain-smart consumer: recognizing good research -- Action or theory: who wants to read all that research -- Excellent sources of research -- Fun factoids on the brain -- What's in the human brain -- Brain teaser -- The brain divided -- The brain connected -- Brain geography -- Brain "cell" ebration: far-out facts about brain cells -- Learning happens but how -- Are today's kids different -- Boy's and girl's brain differences -- Learning disabilities; different brains -- The cranial soup bowl: understanding the chemicals in our brains -- pt. 2. The foundation for teaching is principles, not strategies. What are the principles -- Principle 1: the principle of change: brain is dynamic, not fixed -- Principle 2: the principle of variety: all brains are unique -- Principle 3: the principle of developmental sensitivity -- Principle 4: the principle of interaction: we have a social brain -- Principle 5: the principle of connectivity: the brain is an integrated system of systems -- Principle 6: the principle of memory malleability -- Principle 7: the principle of resource consumption -- necessity for processing -- pt. 3. So what; now what. Asking big questions: what's in a brain-compatible curriculum -- Brain-compatible test-taking success strategies -- Systemic change: the next level -- Big picture analysis: transformation happens -- Action research makes a difference -- The learning community -- What's next.
Publisher:
Corwin Press,
Publication Place:
Thousand Oaks, CA :
ISBN:
9781412954075 (cloth: alk. paper)
141295407X (cloth: alk. paper)
9781412954181 (pbk. : alk. paper)
1412954185 (pbk. : alk. paper)
Subject:
Learning -- Physiological aspects -- Popular works.
Brain -- Popular works.
Edition:
2nd ed.
Contents:
pt. 1. Background you need. -- What is brain-compatible teaching -- The old and new of it -- When brain research is applied to the classroom everything will change -- Change can be easy -- We're not in Kansas anymore -- Where's the proof -- Tools for exploring the brain -- Ten reasons to care about brain research -- The evolution of brain models -- Be a brain-smart consumer: recognizing good research -- Action or theory: who wants to read all that research -- Excellent sources of research -- Fun factoids on the brain -- What's in the human brain -- Brain teaser -- The brain divided -- The brain connected -- Brain geography -- Brain "cell" ebration: far-out facts about brain cells -- Learning happens but how -- Are today's kids different -- Boy's and girl's brain differences -- Learning disabilities; different brains -- The cranial soup bowl: understanding the chemicals in our brains -- pt. 2. The foundation for teaching is principles, not strategies. What are the principles -- Principle 1: the principle of change: brain is dynamic, not fixed -- Principle 2: the principle of variety: all brains are unique -- Principle 3: the principle of developmental sensitivity -- Principle 4: the principle of interaction: we have a social brain -- Principle 5: the principle of connectivity: the brain is an integrated system of systems -- Principle 6: the principle of memory malleability -- Principle 7: the principle of resource consumption -- necessity for processing -- pt. 3. So what; now what. Asking big questions: what's in a brain-compatible curriculum -- Brain-compatible test-taking success strategies -- Systemic change: the next level -- Big picture analysis: transformation happens -- Action research makes a difference -- The learning community -- What's next.
Physical Description:
xi, 123 p. : ill. ;
Electronic Location:
http://www.loc.gov/catdir/toc/ecip077/2006102763.html
http://www.loc.gov/catdir/enhancements/fy0743/2006102763-b.html
http://www.loc.gov/catdir/enhancements/fy0743/2006102763-d.html
Publication Date:
c2007.
Title:
Introduction to bryology / W.B. Schofield.
Author:
Schofield, W. B.
General Notes:
Includes bibliographies and index.
Publisher:
Macmillan ; Collier Macmillan,
Publication Place:
New York : London :
ISBN:
0029496608
Subject:
Bryophytes.
Physical Description:
xvi, 431 p. : ill. ;
Publication Date:
c1985.
Title:
Introduction to business : how companies create value for people / Gareth R. Jones.
Author:
Jones, Gareth R.
General Notes:
Includes bibliographical references (pages N1-N5) and indexes.
What is business? -- The evolution of business -- Entrepreneurs, managers, and employees -- Multinationals and the global environment of business -- Business ethics and the legal environment of business -- Leadership, influence, and the communication of business -- Motivating and managing people and groups in business organizations -- The structure and culture of a business organization -- Information technology and E-commerce : managing information, knowledge, and business relationships -- Marketing and product development : creating and positioning goods and services -- Sales, distribution, and customer relationship management : reaching and satisfying customers -- Operations and materials management : managing the production and flow of goods and services -- Human resource management : acquiring and building employees' skills and capabilities -- Accounting : measuring how efficiently and effectively resources are creating value and profit -- Finance : balancing risk and return to increase profitability.
Publisher:
McGraw-Hill/Irwin,
Publication Place:
Boston :
ISBN:
0071252991
Subject:
Industrial management.
Business.
Industries -- Social aspects.
Contents:
What is business? -- The evolution of business -- Entrepreneurs, managers, and employees -- Multinationals and the global environment of business -- Business ethics and the legal environment of business -- Leadership, influence, and the communication of business -- Motivating and managing people and groups in business organizations -- The structure and culture of a business organization -- Information technology and E-commerce : managing information, knowledge, and business relationships -- Marketing and product development : creating and positioning goods and services -- Sales, distribution, and customer relationship management : reaching and satisfying customers -- Operations and materials management : managing the production and flow of goods and services -- Human resource management : acquiring and building employees' skills and capabilities -- Accounting : measuring how efficiently and effectively resources are creating value and profit -- Finance : balancing risk and return to increase profitability.
Physical Description:
xv, 507, G-10, N-5, PC-1, I-17 pages : color illustrations ; 1 DVD-ROM (4 3/4 in.)
Electronic Location:
http://catdir.loc.gov/catdir/enhancements/fy0668/2005056249-d.html
Publication Date:
2007.
Title:
An introduction to business ethics / Joseph DesJardins.
Author:
DesJardins, Joseph R. author.
General Notes:
Previous ed.: 2002., Previous ed.: 2002.
Publisher:
McGraw-Hill Higher Education ; McGraw-Hill [distributor],
Publication Place:
New York : London :
ISBN:
9780071244374 (pbk.: International ed.)
0071244379 (pbk.: International ed.)
Subject:
Business ethics.
Edition:
2nd ed.
Physical Description:
xiii, 271,(15) p.: ill.;
Publication Date:
2006.
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