Title:
Molecular- and Nano-Tubes edited by Oliver Hayden, Kornelius Nielsch.
Author:
Hayden, Oliver.
Nielsch, Kornelius.
SpringerLink (Online service)
General Notes:
Foreword -- Introduction -- Molecular Scale Tubes -- Supramolecular Tubes -- Carbon Nanotubes -- Inorganic Nanotubes.
<p><i>Molecular- and Nano-Tubes</i> summarizes recent advancements in the synthesis, fabrication and applications of tubular structures. An interdisciplinary overview of innovative science focused on tubular structures is provided. The reader is offered an overview of the different fields that molecular and nano tubes appear in, in order to learn the fundamental basics as well as the applications of these materials. This book also: </p><ul><li>Shows how nanotechnology creates novel materials by crossing the barriers between biology and material science, electronics and optics, medicine and more</li><li>Demonstrates that tubes are a fundamental element in nature and used in disparate applications such as ion channels and carbon nanotubes </li></ul><p><i>Molecular- and Nano-Tubes </i>is an ideal volume for researchers and engineers working in materials science and nanotechnology.</p>
Publisher:
Springer US,
Publication Place:
Boston, MA :
ISBN:
9781441994431
Subject:
Chemistry, Inorganic.
Materials.
Nanotechnology.
Materials science.
Nanotechnology.
Condensed Matter Physics.
Inorganic Chemistry.
Materials Science, general.
Edition:
1.
Contents:
Foreword -- Introduction -- Molecular Scale Tubes -- Supramolecular Tubes -- Carbon Nanotubes -- Inorganic Nanotubes.
Physical Description:
XI, 473p. 252 illus., 36 illus. in color. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4419-9443-1
Publication Date:
2011.
Title:
Molecular Allergy Diagnostics Innovation for a Better Patient Management / edited by Jörg Kleine-Tebbe, Thilo Jakob.
Author:
Kleine-Tebbe, Jörg. editor.
Jakob, Thilo. editor.
SpringerLink (Online service)
General Notes:
Foreword -- Preface -- 1 Introduction to molecular allergy diagnostics: Protein families, allergen data banks and benefits for the use in clinical routine. - I Protein families and relationships -- 2 Bet v 1 and homologues -- 3 Pollen- panallergens: Profilins and polcalcins -- 4 Stable plant food allergens I: Lipid transfer proteins -- 5 Stable plant food allergens I: Storage proteins -- 6 Cross reactive carbohydrate determinants -- II Test systems, singleplex, multiplex analysis -- 7 Molecular allergy diagnostics as singleplex IgE determinations: Methodological and practical consideration for the use in clinical routine -- 8 Spiking with recombinant allergens to improve performance of allergen extracts. – 9 Molecular allergy diagnostics using multiplex IgE determinations. Benefits and limitations for the use in clinical routine. – III Molecular allergy diagnostics in clinical routine -- 10 Marker allergens and pan allergens in tree and grass pollen allergy -- 11 Marker allergens in weed pollen allergy -- 12 Molecular diagnostics of peanut allergy.-13 Molecular diagnostics of nut allergy -- 14 Molecular diagnostics of allergy to fruits and vegetables -- 15 Molecular diagnostic in allergy to cow milk and hen egg -- 16 Molecular diagnostics in meat allergy (t.b.c.) -- 17 Molecular diagnostics in food dependent exercise induced anaphylaxis. 18 Optimized diagnostics in insect venom allergy using recombinant allergens -- 19 Molecular diagnostics in inhalant animal allergens -- 20 Extract based and molecular diagnostics in fish allergy -- 21 Allergens of house dust mites and diagnostics in HDM allergy -- 22 Allergy to cockcroaches, ticks, storage mites, and other arthropods: molecular aspects -- 23 Mould allergens -- 24 Latex allergens -- IV Designer-Allergens, Hypoallergens -- 25 Recombinant allergens in specific immunotherapy -- 26 Definition and design of hypoallergenic food.
This book, based on a recent German publication, offers an overview of basic data and recent developments in the groundbreaking field of molecular allergology. It comprehensively explores the origin and structure of single allergen molecules ("components") and their utility in improving the management of type I, IgE-mediated allergic reactions and disorders like allergic respiratory diseases, food allergies, and anaphylaxis. Highly specific testing, called component-resolved diagnostics, aims to identify and utilize single molecules. Over 200 single allergens from plant or animal sources have been applied to single or multiplex laboratory testing for the presence of allergen-specific IgE. This leap in assay sensitivity and specificity has led to three major advances in patient management: discrimination between primary allergic sensitization and complex cross-reactivity, recognition of IgE profiles for certain allergens and identification of patients most likely to benefit from allergen-specific immunotherapy. The book discusses in detail the benefits and limitations of this 21st century technology, and offers suggestions for the use of molecular allergology in routine clinical practice. It is a “must read” for physicians treating allergic patients as well as scientists interested in natural allergic molecules and their interactions with the human immune system.
Publisher:
Springer International Publishing : Imprint: Springer,
Publication Place:
Cham :
ISBN:
9783319424996
Subject:
Medicine.
Allergy.
Dermatology.
General practice (Medicine).
Respiratory organs -- Diseases.
Otorhinolaryngology.
Pediatrics.
Medicine & Public Health.
Allergology.
Dermatology.
Pediatrics.
Otorhinolaryngology.
Pneumology/Respiratory System.
General Practice / Family Medicine.
Contents:
Foreword -- Preface -- 1 Introduction to molecular allergy diagnostics: Protein families, allergen data banks and benefits for the use in clinical routine. - I Protein families and relationships -- 2 Bet v 1 and homologues -- 3 Pollen- panallergens: Profilins and polcalcins -- 4 Stable plant food allergens I: Lipid transfer proteins -- 5 Stable plant food allergens I: Storage proteins -- 6 Cross reactive carbohydrate determinants -- II Test systems, singleplex, multiplex analysis -- 7 Molecular allergy diagnostics as singleplex IgE determinations: Methodological and practical consideration for the use in clinical routine -- 8 Spiking with recombinant allergens to improve performance of allergen extracts. – 9 Molecular allergy diagnostics using multiplex IgE determinations. Benefits and limitations for the use in clinical routine. – III Molecular allergy diagnostics in clinical routine -- 10 Marker allergens and pan allergens in tree and grass pollen allergy -- 11 Marker allergens in weed pollen allergy -- 12 Molecular diagnostics of peanut allergy.-13 Molecular diagnostics of nut allergy -- 14 Molecular diagnostics of allergy to fruits and vegetables -- 15 Molecular diagnostic in allergy to cow milk and hen egg -- 16 Molecular diagnostics in meat allergy (t.b.c.) -- 17 Molecular diagnostics in food dependent exercise induced anaphylaxis. 18 Optimized diagnostics in insect venom allergy using recombinant allergens -- 19 Molecular diagnostics in inhalant animal allergens -- 20 Extract based and molecular diagnostics in fish allergy -- 21 Allergens of house dust mites and diagnostics in HDM allergy -- 22 Allergy to cockcroaches, ticks, storage mites, and other arthropods: molecular aspects -- 23 Mould allergens -- 24 Latex allergens -- IV Designer-Allergens, Hypoallergens -- 25 Recombinant allergens in specific immunotherapy -- 26 Definition and design of hypoallergenic food.
Physical Description:
XX, 531 p. 112 illus., 100 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-42499-6
Publication Date:
2017.
Title:
Molecular analysis and genome discovery / edited by Ralph Rapley and Stuart Harbron.
Author:
Rapley, Ralph. Ja.
Harbron, Stuart. Ja.
General Notes:
Includes bibliographical references and index.
Pharmacogenetics and pharmacogenomics: an overview / W. Kalow -- Quantitative TaqMan real-time PCR: diagnostic and scientific applications / Jèorg Dèotsch, Ellen Schoof, and Wolfgang Rascher -- Hybridization probes for quantitative PCR / Elaine Lyon -- An overview of genotyping and single nucleotide polymorphisms (SNP) / Ivo Glynne Gut -- High-throughput mutation screening / Paal Skytt Andersen and Lars Allan Larsen -- Determination of nucleic acid sequence by pyrosequencing / Elaine Elahi and Mostafa Ronaghi -- An introduction to DNA chips / Magdalena Gabig-Ciminska and Andrzej Ciminski -- Overview of microarrays in genomic analysis / Janette K. Burgess -- Overview of differential gene expression by high-throughput analysis / Kin-Ying To --
Aptamers: powerful molecular tools for therapeutics and diagnostics / Eva Baldrich i Rubio, Monica Campos i Homs, and Ciara K. O'Sullivan -- Chip-based proteomics technology / Mikhail Soloviev, Richard Barry, and Jon Terrett -- Infectomics overview: holistic and integrative studies of infectious diseases / Sheng-He Huang and Ambrose Jong -- The drug discovery process / Roberto Solari -- Structure-based drug discovery / Chen-Chen Kan, Kevin Hambly, and Derek A. Debe -- Protein interaction-targeted drug discovery / Gary Hudes, Sanjay Menon, and Erica A. Golemis -- Overview of quantitative structure-activity relationships (QSAR) / David A. Winkler.
Publisher:
J. Wiley,
Publication Place:
Chichester, West Sussex, England ; Hoboken, N.J. :
ISBN:
0471499196 (pbk. : alk. paper)
Subject:
Genomics.
Proteomics.
Polymerase chain reaction.
dnamicroarrays.
Pharmacogenetics -- Methods.
Biological Markers.
Genetic Techniques.
Quantitative Structure-Activity Relationship.
Contents:
Pharmacogenetics and pharmacogenomics: an overview / W. Kalow -- Quantitative TaqMan real-time PCR: diagnostic and scientific applications / Jèorg Dèotsch, Ellen Schoof, and Wolfgang Rascher -- Hybridization probes for quantitative PCR / Elaine Lyon -- An overview of genotyping and single nucleotide polymorphisms (SNP) / Ivo Glynne Gut -- High-throughput mutation screening / Paal Skytt Andersen and Lars Allan Larsen -- Determination of nucleic acid sequence by pyrosequencing / Elaine Elahi and Mostafa Ronaghi -- An introduction to DNA chips / Magdalena Gabig-Ciminska and Andrzej Ciminski -- Overview of microarrays in genomic analysis / Janette K. Burgess -- Overview of differential gene expression by high-throughput analysis / Kin-Ying To --
Aptamers: powerful molecular tools for therapeutics and diagnostics / Eva Baldrich i Rubio, Monica Campos i Homs, and Ciara K. O'Sullivan -- Chip-based proteomics technology / Mikhail Soloviev, Richard Barry, and Jon Terrett -- Infectomics overview: holistic and integrative studies of infectious diseases / Sheng-He Huang and Ambrose Jong -- The drug discovery process / Roberto Solari -- Structure-based drug discovery / Chen-Chen Kan, Kevin Hambly, and Derek A. Debe -- Protein interaction-targeted drug discovery / Gary Hudes, Sanjay Menon, and Erica A. Golemis -- Overview of quantitative structure-activity relationships (QSAR) / David A. Winkler.
Physical Description:
xv, 372 p : ill ;
Publication Date:
2004.
Title:
Biosynthesis / [edited by] Smith and Wood.
Molecular and cell biochemistry.
Author:
Smith, C. A. (Chris A.)
WOOD, Edward J., 1941-
General Notes:
Includes bibliographical references and index.
Basic principles of biosynthesis -- Photosynthesis -- Carbohydrates and gluconeogenesis -- Polysaccharides -- Nitrogen fixation: incorporation of nitrogen into amino acids -- Amino acid interconversions -- Purines and pyrimidines -- Lipid biosynthesis -- Polyisoprenoids and porphyrins.
Publisher:
Chapman and Hall,
Publication Place:
London ; New York :
ISBN:
0412407604
Subject:
Biosynthesis.
Biochemistry.
Series:
Molecular and cell biochemistry.
Edition:
1st ed.
Contents:
Basic principles of biosynthesis -- Photosynthesis -- Carbohydrates and gluconeogenesis -- Polysaccharides -- Nitrogen fixation: incorporation of nitrogen into amino acids -- Amino acid interconversions -- Purines and pyrimidines -- Lipid biosynthesis -- Polyisoprenoids and porphyrins.
Physical Description:
xiv, 226 p. ill. (some col.) ;
Publication Date:
1992.
Title:
Molecular and cellular approaches to neural development / edited by W. Maxwell Cowan, Thomas M. Jessell, S. Lawrence Zipursky.
Author:
Cowan, W. Maxwell.
Jessell, Thomas M.
Zipursky, Stephen Lawrence.
General Notes:
Includes bibliographical references and index.
Neural induction in Xenopus / Richard M. Harland -- The determination of the neuronal phenotype / David J. Anderson, Yuh Nung Jan -- Neuron-glial interactions / Barbara A. Barres -- Molecular mechanisms of axon guidance and target recognition / Corey S. Goodman, Marc Tessier-Lavigne -- Synapse formation : a molecular perspective / Joshua R. Sanes, Richard H. Scheller -- Neurotrophic factors and their receptors : roles in neuronal development and function / Louis F. Reichardt, Isabel Fariنnas -- Neuronal cell death / Julie Agapite, Hermannn Stellar -- Inductive signals and the assignment of cell fate in the spinal cord and hindbrain : an axial coordinate system for neural patterning / Thomas M. Jessell, Andrew Lumsden -- The role of hox genes in hindbrain development / Mario R. Capecchi -- Regulation of patterning and differentiation in the embryoinc vertebrate forebrain / John L.R. Rubenstein, Kenji Shimamura -- Lineage analysis in the vertebrate central nervous system / Constance L. Cepko ... [et al'] -- Development of the cerebral cortex : mechanisms controlling cell fate, laminar and areal patterning, and axonal connectivity / Anjen Chenn ... [et al.] -- The development of the drosophila visual system / Tanya Wolff ... [et al.] -- Neurotrophins and visual system plasticity / Carla J. Shatz -- Linking layers and connecting columns : the development of local circuits in visual cortex / Lawrence C. Katz.
Publisher:
Oxford University Press,
Publication Place:
New York :
ISBN:
0195111664 (alk. paper)
Subject:
Developmental neurobiology.
MOLECULAR NEUROBIOLOGY.
Nervous System -- growth & development.
Neurons -- physiology.
Developmental Biology.
Contents:
Neural induction in Xenopus / Richard M. Harland -- The determination of the neuronal phenotype / David J. Anderson, Yuh Nung Jan -- Neuron-glial interactions / Barbara A. Barres -- Molecular mechanisms of axon guidance and target recognition / Corey S. Goodman, Marc Tessier-Lavigne -- Synapse formation : a molecular perspective / Joshua R. Sanes, Richard H. Scheller -- Neurotrophic factors and their receptors : roles in neuronal development and function / Louis F. Reichardt, Isabel Fariنnas -- Neuronal cell death / Julie Agapite, Hermannn Stellar -- Inductive signals and the assignment of cell fate in the spinal cord and hindbrain : an axial coordinate system for neural patterning / Thomas M. Jessell, Andrew Lumsden -- The role of hox genes in hindbrain development / Mario R. Capecchi -- Regulation of patterning and differentiation in the embryoinc vertebrate forebrain / John L.R. Rubenstein, Kenji Shimamura -- Lineage analysis in the vertebrate central nervous system / Constance L. Cepko ... [et al'] -- Development of the cerebral cortex : mechanisms controlling cell fate, laminar and areal patterning, and axonal connectivity / Anjen Chenn ... [et al.] -- The development of the drosophila visual system / Tanya Wolff ... [et al.] -- Neurotrophins and visual system plasticity / Carla J. Shatz -- Linking layers and connecting columns : the development of local circuits in visual cortex / Lawrence C. Katz.
Physical Description:
x, 563 p. : ill. (some col.) ;
Publication Date:
1997.
Title:
Molecular and Cellular Biology of Platelet Formation Implications in Health and Disease / edited by Harald Schulze, Joseph Italiano.
Author:
Schulze, Harald. editor.
Italiano, Joseph. editor.
SpringerLink (Online service)
General Notes:
I. Thrombopoiesis 1. A short history of the platelet (N.N.) -- 2. Megakaryopoiesis and Platelet biogenesis (Italiano) -- 3. Transcription factors in MKs and platelets (Cantor / Tijssen & Ghavaert) -- 4. Platelet biogenesis in vivo and the Vascular Niche (Schulze). II. Platelet biology -- 5. Platelet contents (Hartwig) -- 6. Platelet signal transduction (Yonis / S. Watson) -- 7. Thrombosis (Bergmeier) -- 8. Platelets and coagulation (N.N.) -- 9. The platelet life span (Kile). III. Animal models 10. Platelets in mice and men (N.N) -- 11. Animal models for platelet function (Nieswandt) -- 12. Other animal models /zebrafish (N.N.). IV. Platelets in Health and Disease -- 13. Platelet parameters and function testing in the clinic (Schulze / Dame) -- 14. Atherothrombosis and Coronary Artery Disease (Nieswandt) -- 15. Thrombocytopenias and Thrombocytopathies (Ballmaier) -- 16. Platelets in myeloproliferative disorders and leukemia (N.N.) -- 17. Platelet Apheresis and Transfusions (N.N) -- 18. Platelet Biogenesis following Stem Cell Transplantation (N.N).
This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular biology, hematopoiesis and hemostasis and specifically for scientists in platelet research, as well as for clinicians in the field of hematology and transfusion medicine. .
Publisher:
Springer International Publishing : Imprint: Springer,
Publication Place:
Cham :
ISBN:
9783319395623
Subject:
Medicine.
Gene therapy.
Human physiology.
Molecular biology.
Blood transfusion.
Hematology.
Cell biology.
Biomedicine.
Human physiology.
Hematology.
Cell biology.
Gene therapy.
Molecular Medicine.
Blood Transfusion Medicine.
Contents:
I. Thrombopoiesis 1. A short history of the platelet (N.N.) -- 2. Megakaryopoiesis and Platelet biogenesis (Italiano) -- 3. Transcription factors in MKs and platelets (Cantor / Tijssen & Ghavaert) -- 4. Platelet biogenesis in vivo and the Vascular Niche (Schulze). II. Platelet biology -- 5. Platelet contents (Hartwig) -- 6. Platelet signal transduction (Yonis / S. Watson) -- 7. Thrombosis (Bergmeier) -- 8. Platelets and coagulation (N.N.) -- 9. The platelet life span (Kile). III. Animal models 10. Platelets in mice and men (N.N) -- 11. Animal models for platelet function (Nieswandt) -- 12. Other animal models /zebrafish (N.N.). IV. Platelets in Health and Disease -- 13. Platelet parameters and function testing in the clinic (Schulze / Dame) -- 14. Atherothrombosis and Coronary Artery Disease (Nieswandt) -- 15. Thrombocytopenias and Thrombocytopathies (Ballmaier) -- 16. Platelets in myeloproliferative disorders and leukemia (N.N.) -- 17. Platelet Apheresis and Transfusions (N.N) -- 18. Platelet Biogenesis following Stem Cell Transplantation (N.N).
Physical Description:
X, 460 p. 56 illus., 41 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-39562-3
Publication Date:
2016.
Title:
Molecular and Cellular Enzymology by Jeannine Yon-Kahn, G. Hervé.
Author:
Yon-Kahn, Jeannine.
Hervé, G.
SpringerLink (Online service)
General Notes:
<P>Thermodynamic laws – Notion of chemical equilibrium -- Equilibrium of protein –ligands association The living organisms, open systems -- Chemical kinetics -- Experimental methods to study the enzyme reactions Origin of enzymes and evolution -- Formation of the functional structure of enzymes : co- and post-translational events -- Topology of the active center of enzymes -- Formation of the enzyme-substrate complexes -- Catalytic mechanisms -- Examples of structure-function relationships in enzyme systems -- Regulation through non-covalent interactions -- Covalent regulations -- Multifunctional enzymes, multienzyme complexes and metabolic channeling Cellular localisation and compartmentation -- Kinetics of enzyme reactions catalyzed by immobilized enzymes -- Theory of the control of metabolic pathways.</P>.
<P>Molecular and Cellular Enzymology addresses not only experienced enzymologists but also students, teachers and academic and industrial researchers who are confronted with enzymological problems during their fundamental or applied research. In this field there is an urgent need for training in order to meet the requirements of both research and industrial endeavours. This book consists of several levels. Practical aspects and elementary explanations are given for the benefit of non-specialists’ and students’ understanding. In order to facilitate the task of students, two typographies have been adopted. The main text corresponds to basic knowledge, whereas text in a smaller font provides more specialised information. Specialists will also find topics more deeply expounded with the principal bibliographic references cited. The bibliography, however, is not exhaustive; the choice includes general books and review articles as well as some specialised articles. In this book, for the first time, the different molecular and cellular aspects of enzymology are presented together. Until now, there has been no book available in which these different aspects are treated in the same volume. In addition, besides the theoretical developments, this book provides a wealth of practical information for experimentalists.</P>
Publisher:
Springer Berlin Heidelberg,
Publication Place:
Berlin, Heidelberg :
ISBN:
9783642012280
Subject:
Life sciences.
Chemistry, Physical organic.
Biochemistry.
Enzymes.
Life sciences.
Enzymology.
Physical chemistry.
Medical Biochemistry.
Medicinal Chemistry.
Contents:
<P>Thermodynamic laws – Notion of chemical equilibrium -- Equilibrium of protein –ligands association The living organisms, open systems -- Chemical kinetics -- Experimental methods to study the enzyme reactions Origin of enzymes and evolution -- Formation of the functional structure of enzymes : co- and post-translational events -- Topology of the active center of enzymes -- Formation of the enzyme-substrate complexes -- Catalytic mechanisms -- Examples of structure-function relationships in enzyme systems -- Regulation through non-covalent interactions -- Covalent regulations -- Multifunctional enzymes, multienzyme complexes and metabolic channeling Cellular localisation and compartmentation -- Kinetics of enzyme reactions catalyzed by immobilized enzymes -- Theory of the control of metabolic pathways.</P>.
Physical Description:
XLIV, 783p. 370 illus., 36 illus. in color. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-3-642-01228-0
Publication Date:
2010.
Title:
Molecular and cellular exercise physiology / Frank C. Mooren, Klaus Vèolker, editors.
Author:
Mooren, Frank, 1964-
Vèolker, Klaus, 1968-
General Notes:
Includes bibliographical references (p. 347-439) and index.
The cell -- Cellular life span -- Genes, genetic heterogeneity, and exercise phenotypes -- Proteins and exercise -- Extracellular matrix and exercise -- Regulation of intracellular ion composition and pH -- Inter- and intracellular signaling -- Energy turnover and substrate utilization -- Generation and disposal of reactive oxygen and nitrogen species -- Cellular responses to environmental stress -- Exercise and the cardiac myocyte -- Exercise and endothelium -- Activity-dependent adaptive responses of skeletal muscle fibers -- Exercise and the alveolar and bronchial epithelial cell -- Exercise and the liver cell -- Exercise and the adipocyte -- Erythrocytes -- Leukocytes -- Exercise and the brain.
Publisher:
Human Kinetics,
Publication Place:
Champaign, IL :
ISBN:
073604518X (hardcover)
9780736045186 (hardcover)
Subject:
Exercise -- Physiological aspects.
Cell physiology.
Molecular biology.
Cell Physiology.
Cellular Structures -- cytology.
Exercise -- physiology.
Fysiologie.
Cellen (biologie)
Bewegingsleer.
Lichamelijke inspanning.
Exercice -- Aspect physiologique.
Cellules -- Physiologie.
Biologie molâeculaire.
Physiologie
Exercice physique
Effet physiologique
Cellule
Physiologie cellulaire
Aspect molâeculaire
Contents:
The cell -- Cellular life span -- Genes, genetic heterogeneity, and exercise phenotypes -- Proteins and exercise -- Extracellular matrix and exercise -- Regulation of intracellular ion composition and pH -- Inter- and intracellular signaling -- Energy turnover and substrate utilization -- Generation and disposal of reactive oxygen and nitrogen species -- Cellular responses to environmental stress -- Exercise and the cardiac myocyte -- Exercise and endothelium -- Activity-dependent adaptive responses of skeletal muscle fibers -- Exercise and the alveolar and bronchial epithelial cell -- Exercise and the liver cell -- Exercise and the adipocyte -- Erythrocytes -- Leukocytes -- Exercise and the brain.
Physical Description:
x, 453 p. : ill. ;
Publication Date:
c2005.
Title:
Molecular and Cellular Mechanisms of Antibody Activity edited by Falk Nimmerjahn.
Author:
Nimmerjahn, Falk. editor.
SpringerLink (Online service)
General Notes:
IgM and IgD in infection and inflammatory diseases -- Immunoglobulin A – molecular mechanisms of function and role in immune defense -- Crystal structures of human IgG Fc-fragments and their complexes with Fc Receptors -- The role of IgG in immune responses -- Molecular and cellular pathways involved in the anti-inflammatory activity of IgG -- Example of the Pathogenic Potential of Two Sets of Autoantibodies: Anti-RBC and IgG3 RF Cryoglobulins -- Cross-talk between antibodies, IgG Fc receptors and the complement system -- Regulation of immunological responses by the neonatal Fc receptor for IgG, FcRn -- Antibody mediated regulation of humoral immunity -- Engineered antibody derivatives in preclinical and clinical development.
This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of molecules is demonstrated by the heightened susceptibility to infections of humans and mice with an altered capacity to generate pathogen specific antibody responses. Thus, the majority of our currently available vaccines, such as vaccines against influenza, measles and hepatitis focus on the generation of long lasting antibody responses. Recent evidence from a variety of in vivo model systems and from human patient cohorts has highlighted the exclusive role of cellular Fc-receptors for certain immunoglobulin isotypes and subclasses. With the recent discovery of a human Fc-receptor for IgM all different human immunoglobulin isotypes now have a cellular receptor, providing a feedback mechanism and link between antibodies and the cellular components of the immune system. Moreover it has become clear the complement and Fc-receptor system are tightly connected and regulate each other to ensure a well balanced immune response. Among the immunoglobulin isotypes IgG plays a very important protective role against microbial infections and also as a therapeutic agent to kill tumor cells or autoantibody producing B cells in autoimmune disease. Transfer of our knowledge about the crucial function of Fc-receptors has led to the production of a second generation of therapeutic antibodies with enhanced binding to this class of receptors. Binding of antibodies to Fc-receptors leads to the recruitment of the potent pro-inflammatory effector functions of cells from the innate immune system. Hence, Fc-receptors link the innate and adaptive immune system, emphasizing the importance of both arms of the immune system and their crosstalk during anti-microbial immune responses. Besides this pro-inflammatory activity immunoglobulin G (IgG) molecules are long known to also have an anti-inflammatory function. This is demonstrated by the use of high dose intravenous immunoglobulins as a therapeutic agent in many human autoimmune diseases. During the past five years several new insights into the molecular and cellular pathways of this anti-inflammatory activity were gained radically changing our view of IgG function in vivo. Several lines of evidence suggest that the sugar moiety attached to the IgG molecule is responsible for these opposing activities and may be seen as a molecular switch enabling the immune system to change IgG function from a pro- to an anti-inflammatory activity. There is convincing evidence in mice and humans that aberrant IgG glycosylation could be an important new pathway for understanding the impaired antibody activity during autoimmune disease. Besides this tremendous increase in basic knowledge about factors influencing immunoglobulin activity the book will also provide insights into how these new insights might help to generate novel therapeutic approaches to enhance IgG activity for tumor therapy on the one hand, and how to block the self-destructive activity of IgG autoantibodies during autoimmune disease on the other hand.
Publisher:
Springer New York : Imprint: Springer,
Publication Place:
New York, NY :
ISBN:
9781461471073
Subject:
Medicine.
Immunology.
Microbiology.
Medical virology.
Biomedicine.
Immunology.
Medical microbiology.
Virology.
Contents:
IgM and IgD in infection and inflammatory diseases -- Immunoglobulin A – molecular mechanisms of function and role in immune defense -- Crystal structures of human IgG Fc-fragments and their complexes with Fc Receptors -- The role of IgG in immune responses -- Molecular and cellular pathways involved in the anti-inflammatory activity of IgG -- Example of the Pathogenic Potential of Two Sets of Autoantibodies: Anti-RBC and IgG3 RF Cryoglobulins -- Cross-talk between antibodies, IgG Fc receptors and the complement system -- Regulation of immunological responses by the neonatal Fc receptor for IgG, FcRn -- Antibody mediated regulation of humoral immunity -- Engineered antibody derivatives in preclinical and clinical development.
Physical Description:
X, 294 p. 52 illus., 44 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4614-7107-3
Publication Date:
2013.
Title:
Molecular and Cellular Mechanobiology edited by Shu Chien, Adam J. Engler, Peter Yingxiao Wang.
Physiology in Health and Disease
Physiology in Health and Disease
Author:
Chien, Shu. editor.
Engler, Adam J. editor.
Wang, Peter Yingxiao. editor.
SpringerLink (Online service)
General Notes:
Part 1. Mechanosensors -- The Primary Cilium as a Strain Amplifying Microdomain for Mechanotransduction at the Cell Membrane -- Vascular Endothelial Mechanosensors in Response to Fluid Shear Stress -- Cadherins in Mechanotransduction -- Perspectives of FRET Imaging to study Epigenetics and Mechanobiology in the Nucleus -- Part 2. Transducers -- Emerging Roles of YAP/TAZ in Mechanobiology -- Role of Rho GTPases in Mechanobiology -- Illuminating Cell Adhesion: Modern Microscopy Approaches to Study Integrin-Based Focal Adhesions -- Part 3. Epigenetic and Genetic Regulations in the Nucleus -- Mechanotransduction to Epigenetic Remodeling -- The Nuclear Lamina: From Mechano-Sensing in Differentiation to Cancer Cell Migration -- Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and Gene Expression -- Part 4. Applications -- Mechanobiological Control of Cell Fate for Applications in Cardiovascular Regenerative Medicine -- Heart Valve Mechanobiology in Development and Disease -- Molecular and Cellular Mechanobiology of Cancer.
This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.
Publisher:
Springer New York : Imprint: Springer,
Publication Place:
New York, NY :
ISBN:
9781493956173
Subject:
Medicine.
Human physiology.
Molecular biology.
Proteins.
Cell physiology.
Atomic structure.
Molecular structure.
Spectra.
Biomedicine.
Human physiology.
Cell physiology.
Atomic/Molecular Structure and Spectra.
Protein Science.
Molecular Medicine.
Series:
Physiology in Health and Disease
Physiology in Health and Disease
Contents:
Part 1. Mechanosensors -- The Primary Cilium as a Strain Amplifying Microdomain for Mechanotransduction at the Cell Membrane -- Vascular Endothelial Mechanosensors in Response to Fluid Shear Stress -- Cadherins in Mechanotransduction -- Perspectives of FRET Imaging to study Epigenetics and Mechanobiology in the Nucleus -- Part 2. Transducers -- Emerging Roles of YAP/TAZ in Mechanobiology -- Role of Rho GTPases in Mechanobiology -- Illuminating Cell Adhesion: Modern Microscopy Approaches to Study Integrin-Based Focal Adhesions -- Part 3. Epigenetic and Genetic Regulations in the Nucleus -- Mechanotransduction to Epigenetic Remodeling -- The Nuclear Lamina: From Mechano-Sensing in Differentiation to Cancer Cell Migration -- Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and Gene Expression -- Part 4. Applications -- Mechanobiological Control of Cell Fate for Applications in Cardiovascular Regenerative Medicine -- Heart Valve Mechanobiology in Development and Disease -- Molecular and Cellular Mechanobiology of Cancer.
Physical Description:
XIII, 302 p. 58 illus., 57 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4939-5617-3
Publication Date:
2016.
Title:
Molecular and cellular physiology of neurons / Gordon L. Fain.
Author:
Fain, Gordon L.
General Notes:
Includes bibliographical references (p. [585]-684) and index.
Pt. 1. Electrical properties of cells and homeostasis. Passive electrical properties of neurons ; Ion permeability and membrane potentials ; Ion pumps and homeostasis -- Pt. 2. Active propagation of neural signals. Action potentials: the Hodgkin-Huxley experiments ; The structure and function of voltage-gated channels ; The diversity of voltage-gated channels -- Pt. 3. Synaptic transmission and ligand-gated channels. Presynaptic mechanisms of synaptic transmission ; Excitatory transmission ; Inhibitory transmission -- Pt. 4. Metabotropic transmission and neuromodulation. Receptors and G proteins ; Effector molecules ; Calcium and nitric oxide ; Long-term potentiation / by Thomas O'Dell -- Pt. 5. Sensory transduction. Mechanoreceptors ; Photoreceptors and olfactory receptors.
Publisher:
Harvard University Press,
Publication Place:
Cambridge, Mass. :
ISBN:
0674581555 (alk. paper)
Subject:
Neurons.
Neurophysiology.
MOLECULAR NEUROBIOLOGY.
Neurons -- physiology.
Molecular Biology.
Neurobiology.
Neurophysiology.
Neurons -- Physiology.
Molecular neurobiology.
Contents:
Pt. 1. Electrical properties of cells and homeostasis. Passive electrical properties of neurons ; Ion permeability and membrane potentials ; Ion pumps and homeostasis -- Pt. 2. Active propagation of neural signals. Action potentials: the Hodgkin-Huxley experiments ; The structure and function of voltage-gated channels ; The diversity of voltage-gated channels -- Pt. 3. Synaptic transmission and ligand-gated channels. Presynaptic mechanisms of synaptic transmission ; Excitatory transmission ; Inhibitory transmission -- Pt. 4. Metabotropic transmission and neuromodulation. Receptors and G proteins ; Effector molecules ; Calcium and nitric oxide ; Long-term potentiation / by Thomas O'Dell -- Pt. 5. Sensory transduction. Mechanoreceptors ; Photoreceptors and olfactory receptors.
Physical Description:
x, 693 p. : ill. ;
Publication Date:
1999.
Title:
Molecular and cellular physiology of neurons / Gordon L. Fain with Thomas O'Dell ; illustrations by Margery J. Fain.
Author:
Fain, Gordon L., author.
O'Dell, Thomas, 1960- author.
General Notes:
Includes bibliographical references (pages 633-722) and index.
Electrical properties of neurons -- Ion permeability and membrane potentials -- Ion pumps and homeostasis -- Action potentials : the Hodgkin-Huxley experiments -- The structure and function of voltage-gated channels -- The diversity of ion channels -- Presynaptic mechanisms of synaptic transmission / by Thomas O'Dell -- Excitatory transmission -- Inhibitory transmission / by Thomas O'Dell -- Metabotropic transmission : receptors and G proteins -- Metabotropic transmission : effector molecules -- Metabotropic transmission : calcium -- Long-term potentiation / by Thomas O'Dell -- Mechanoreceptors -- Photoreceptors.
Publisher:
Harvard University Press,
Publication Place:
Cambridge, Massachusetts :
ISBN:
9780674599215 (hbk.)
0674599217 (hbk.)
Subject:
Neurons -- physiology.
Molecular Biology.
Nervous System Physiological Processes.
Neurobiology.
Edition:
Second edition.
Contents:
Electrical properties of neurons -- Ion permeability and membrane potentials -- Ion pumps and homeostasis -- Action potentials : the Hodgkin-Huxley experiments -- The structure and function of voltage-gated channels -- The diversity of ion channels -- Presynaptic mechanisms of synaptic transmission / by Thomas O'Dell -- Excitatory transmission -- Inhibitory transmission / by Thomas O'Dell -- Metabotropic transmission : receptors and G proteins -- Metabotropic transmission : effector molecules -- Metabotropic transmission : calcium -- Long-term potentiation / by Thomas O'Dell -- Mechanoreceptors -- Photoreceptors.
Physical Description:
xi, 735 pages : illustrations (some color) ;
Publication Date:
2014.
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