Title:
Molecular and Functional Models in Neuropsychiatry edited by Jim J. Hagan.
Current Topics in Behavioral Neurosciences,
Current Topics in Behavioral Neurosciences,
Author:
Hagan, Jim J.
SpringerLink (Online service)
General Notes:
From the contents: Preface -- Mouse mutagenesis and disease models for Neuropsychiatric disorders. - Drosophila as a model organism for the study of neuropsychiatric disorders -- Transgenic animal models of Huntington’s Disease -- Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges -- Animal Models of Depression: Molecular Perspectives.-Animal models of ADHD -- Mouse Models of Autism: Testing Hypotheses about Molecular Mechanisms -- Advances in animal models of drug addiction -- When the serotonin transporter gene meets adversity: The contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience -- Functional and Pharmacological MRI in understanding brain function at a systems level -- The pig as model animal for studying cognition and neurobehavioral disorders.
<p>Common neuropsychiatric diseases are associated with significant human and economic cost. The development of more effective treatments requires scientific progress on a broad front and animal models have a vital role to play in these advances, enabling exploration of the functional consequences of molecular changes at the cellular, systems and behavioural levels. This volume discusses some of the latest and most exciting advances in the field. The first five chapters consider developments in gene modification techniques, their applications <i>in vivo</i> across a variety of species and the latest work related to Schizophrenia, Huntington’s Disease and Major Depressive Disorder. Three chapters then focus on recent developments in Autism, Drug Dependence and Attention Deficit Hyperactivity Disorder. In the final four chapters consideration is given to the development of models in larger species and to emergent approaches, such as epigenetic regulation, gene X environment interactions and MRI as a tool for understanding the function of neuronal systems in non- human species, all of which are likely to play an increasingly important role in the scientific discourse related to neuropsychiatric diseases.</p>
Publisher:
Springer Berlin Heidelberg,
Publication Place:
Berlin, Heidelberg :
ISBN:
9783642197031
Subject:
Medicine.
Neurosciences.
Neurology.
Psychiatry.
Psychopharmacology.
Animal behavior.
Biomedicine.
Neurosciences.
Molecular Medicine.
Psychopharmacology.
Psychiatry.
Neurology.
Behavioural Sciences.
Series:
Current Topics in Behavioral Neurosciences, 7
Current Topics in Behavioral Neurosciences, 7
Contents:
From the contents: Preface -- Mouse mutagenesis and disease models for Neuropsychiatric disorders. - Drosophila as a model organism for the study of neuropsychiatric disorders -- Transgenic animal models of Huntington’s Disease -- Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges -- Animal Models of Depression: Molecular Perspectives.-Animal models of ADHD -- Mouse Models of Autism: Testing Hypotheses about Molecular Mechanisms -- Advances in animal models of drug addiction -- When the serotonin transporter gene meets adversity: The contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience -- Functional and Pharmacological MRI in understanding brain function at a systems level -- The pig as model animal for studying cognition and neurobehavioral disorders.
Physical Description:
XIV, 392p. 29 illus. in color. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-3-642-19703-1
Publication Date:
2011.
Title:
Molecular and genetic aspects of nitrate assimilation / edited by John L. Wray and James R. Kinghorn.
Author:
Wray, John L. (John Langford), 1942-
Kinghorn, James R.
General Notes:
Includes bibliographies and index.
Molecular aspects of nitrate uptake in higher plants / C.-M. Larsson and B. Ingemarsson -- The genetics of nitrate uptake in higher plants / Roger M. Wallsgrove ... [et al.] -- Involvement of the chlorate resistance loci and the molybdenum cofactor in the biosynthesis of the Escherichia coli respiratory nitrate reductase / David H. Boxer -- Biochemistry, regulatory aspects, and genetics of nitrate assimilation in cyanobacteria / Alexandra J. Andriesse, Peter J. Weisbeek, and Gerard A. van Arkel -- Nitrate assimilation in yeasts / Charles R. Hipkin -- Genetic, biochemical, and structural organization of the Aspergillus nidulans crnA-niiA-niaD gene cluster / James R. Kinghorn -- Structure-function relationships of algal nitrate reductases / Larry P. Solomonson and Michael J. Barber -- Genetics and regulatory aspects of nitrate assimilation in algae / Emilio Fernâandez and Jacobo Câardenas.
Structure and regulation of nitrate reductase in higher plants / Wilbur H. Campbell -- Immunology of nitrate reductase with special reference to higher plants / Brian A. Notton -- Biochemical and somatic cell genetics of nitrate reduction in Nicotiana / Andreas J. Muller and Ralf R. Mendel -- Molecular genetics of nitrate reduction in Nicotiana / Michel Caboche ... [et al.] -- Molecular genetics of nitrate reductase in barley / A. Kleinhofs ... [et al.] -- Chemistry and biology of the molybdenum cofactor / K.V. Rajagopalan -- Physiology, biochemistry, and genetics of nitrite reduction by Escherichia coli / J.A. Cole -- Molecular and genetic aspects of nitrite reduction in higher plants / John L. Wray -- Structure and function of spinach ferredoxin-nitrite reductase / Lewis M. Siegel and James O. Wilkerson.
Molecular cloning of spinach nitrite reductase / E. Back ... [et al.] -- Regulation of nitrate assimilation in Aspergillus nidulans / Claudio Scazzocchio and Herbert N. Arst, Jr. -- Genetics, regulation, and molecular studies of nitrate assimilation in Neurospora crassa / George Marzluf and Ying-Hui Fu -- Molecular analysis of nitrate regulation of nitrate reductase in squash and Arabidopsis / Nigel M. Crawford and Ronald W. Davis -- Fungal biotechnology and the nitrate assimilation pathway / Shiela E. Unkles -- Plant biotechnology and nitrate assimilation / D. Cammaerts ... [et al.] -- Amino acid sequence relationships between bacterial, fungal, and plant nitrate reductase and nitrite reductase proteins / James R. Kinghorn and E.I. Campbell.
(Publisher-supplied data) There is considerable interest in the mechanisms of nitrate regulation from both agriculture and industry because effective nitrate metabolism is vital for healthy plant growth. This book addresses aspects of both fungal and higher plant metabolism. It examines the genetics and molecular biology of nitrate uptake, reduction, and regulation, and identifies future research priorities.
Publisher:
Oxford Science Publications ; Oxford University Press,
Publication Place:
Oxford [England] : New York :
ISBN:
019857696X :
9780198576969
Subject:
Nitrates -- Metabolism.
Plants -- Assimilation.
Fungi -- Metabolism.
Nitrates -- Metabolism -- Genetic aspects.
Nitrates -- Metabolism -- Regulation.
Plantes -- Assimilation.
Nitrates -- Mâetabolisme.
Champignons -- Mâetabolisme.
Nitrates -- Mâetabolisme -- Aspect gâenâetique.
Nitrates -- Mâetabolisme -- Râegulation.
Nitrates -- metabolism.
Nitrites -- metabolism.
Bacteria -- genetics.
Fungi -- genetics.
Nitrate Reductase -- metabolism.
Plants -- genetics.
Plants Nitrogen Fixation
Contents:
Molecular aspects of nitrate uptake in higher plants / C.-M. Larsson and B. Ingemarsson -- The genetics of nitrate uptake in higher plants / Roger M. Wallsgrove ... [et al.] -- Involvement of the chlorate resistance loci and the molybdenum cofactor in the biosynthesis of the Escherichia coli respiratory nitrate reductase / David H. Boxer -- Biochemistry, regulatory aspects, and genetics of nitrate assimilation in cyanobacteria / Alexandra J. Andriesse, Peter J. Weisbeek, and Gerard A. van Arkel -- Nitrate assimilation in yeasts / Charles R. Hipkin -- Genetic, biochemical, and structural organization of the Aspergillus nidulans crnA-niiA-niaD gene cluster / James R. Kinghorn -- Structure-function relationships of algal nitrate reductases / Larry P. Solomonson and Michael J. Barber -- Genetics and regulatory aspects of nitrate assimilation in algae / Emilio Fernâandez and Jacobo Câardenas.
Structure and regulation of nitrate reductase in higher plants / Wilbur H. Campbell -- Immunology of nitrate reductase with special reference to higher plants / Brian A. Notton -- Biochemical and somatic cell genetics of nitrate reduction in Nicotiana / Andreas J. Muller and Ralf R. Mendel -- Molecular genetics of nitrate reduction in Nicotiana / Michel Caboche ... [et al.] -- Molecular genetics of nitrate reductase in barley / A. Kleinhofs ... [et al.] -- Chemistry and biology of the molybdenum cofactor / K.V. Rajagopalan -- Physiology, biochemistry, and genetics of nitrite reduction by Escherichia coli / J.A. Cole -- Molecular and genetic aspects of nitrite reduction in higher plants / John L. Wray -- Structure and function of spinach ferredoxin-nitrite reductase / Lewis M. Siegel and James O. Wilkerson.
Molecular cloning of spinach nitrite reductase / E. Back ... [et al.] -- Regulation of nitrate assimilation in Aspergillus nidulans / Claudio Scazzocchio and Herbert N. Arst, Jr. -- Genetics, regulation, and molecular studies of nitrate assimilation in Neurospora crassa / George Marzluf and Ying-Hui Fu -- Molecular analysis of nitrate regulation of nitrate reductase in squash and Arabidopsis / Nigel M. Crawford and Ronald W. Davis -- Fungal biotechnology and the nitrate assimilation pathway / Shiela E. Unkles -- Plant biotechnology and nitrate assimilation / D. Cammaerts ... [et al.] -- Amino acid sequence relationships between bacterial, fungal, and plant nitrate reductase and nitrite reductase proteins / James R. Kinghorn and E.I. Campbell.
Physical Description:
xv, 410 p. : ill. ;
Electronic Location:
http://www.loc.gov/catdir/enhancements/fy0636/88026844-d.html
http://www.loc.gov/catdir/enhancements/fy0636/88026844-t.html
Publication Date:
1989.
Title:
Assessing Ocular Toxicology in Laboratory Animals edited by Andrea B Weir, Margaret Collins.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Weir, Andrea B. editor.
Collins, Margaret. editor.
SpringerLink (Online service)
General Notes:
Comparative Ocular Anatomy in Commonly Used Laboratory Animals -- Assessment of Ocular Toxicity Potential: Basic Theory and Techniques -- Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Toxicologic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment -- Toxicologic Pathology of the Eye: Alterations of the Lens and Posterior Segment -- Nonclinical Regulatory Aspects for Ophthalmic Drugs -- Ocular Toxicity Regulatory Considerations for Non-Drug Food and Drug.
Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
Publisher:
Humana Press : Imprint: Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781627031646
Subject:
Medicine.
Toxicology.
Ophthalmology.
Morphology (Animals).
Laboratory animals.
Biomedicine.
Pharmacology/Toxicology.
Ophthalmology.
Animal Models.
Animal Anatomy / Morphology / Histology.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Comparative Ocular Anatomy in Commonly Used Laboratory Animals -- Assessment of Ocular Toxicity Potential: Basic Theory and Techniques -- Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Toxicologic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment -- Toxicologic Pathology of the Eye: Alterations of the Lens and Posterior Segment -- Nonclinical Regulatory Aspects for Ophthalmic Drugs -- Ocular Toxicity Regulatory Considerations for Non-Drug Food and Drug.
Physical Description:
XIV, 319 p. 120 illus., 75 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-62703-164-6
Publication Date:
2013.
There are no items available
Title:
Assessing Ocular Toxicology in Laboratory Animals edited by Andrea B Weir, Margaret Collins.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Weir, Andrea B. editor.
Collins, Margaret. editor.
SpringerLink (Online service)
General Notes:
Comparative Ocular Anatomy in Commonly Used Laboratory Animals -- Assessment of Ocular Toxicity Potential: Basic Theory and Techniques -- Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Toxicologic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment -- Toxicologic Pathology of the Eye: Alterations of the Lens and Posterior Segment -- Nonclinical Regulatory Aspects for Ophthalmic Drugs -- Ocular Toxicity Regulatory Considerations for Non-Drug Food and Drug.
Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
Publisher:
Humana Press : Imprint: Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781627031646
Subject:
Medicine.
Toxicology.
Ophthalmology.
Morphology (Animals).
Laboratory animals.
Biomedicine.
Pharmacology/Toxicology.
Ophthalmology.
Animal Models.
Animal Anatomy / Morphology / Histology.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Comparative Ocular Anatomy in Commonly Used Laboratory Animals -- Assessment of Ocular Toxicity Potential: Basic Theory and Techniques -- Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Toxicologic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment -- Toxicologic Pathology of the Eye: Alterations of the Lens and Posterior Segment -- Nonclinical Regulatory Aspects for Ophthalmic Drugs -- Ocular Toxicity Regulatory Considerations for Non-Drug Food and Drug.
Physical Description:
XIV, 319 p. 120 illus., 75 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-62703-164-6
Publication Date:
2013.
There are no items available
Title:
Immunotoxicity, Immune Dysfunction, and Chronic Disease edited by Rodney R. Dietert, Robert W. Luebke.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Dietert, Rodney R. editor.
Luebke, Robert W. editor.
SpringerLink (Online service)
General Notes:
Introduction to Immunotoxicity -- The Environment-Immune Route to Chronic Disease -- Asthma and Respiratory Allergies -- Cutaneous Allergies -- Food Allergies -- Factors Involved in Onset of Type1 Diabetes -- Rheumatoid Arthritis -- Environment, Immune Dysfunction and Systemic Lupus Erythematosus -- Multiple Sclerosis, Alzheimer’s Disease and Inflammation: A Hypothetical View -- Immune Dysfunction in Autism Spectrum Disorders -- Atherosclerosis and Inflammatory Heart Disease -- Inflammatory Bowel Disease and Celiac Disease: Environmental Risks Factors and Consequences -- COPD and Other Inflammatory Diseases of the Lung: Focus on AhR signaling -- Environment, the Immune System, and Depression: An Integrative Review and Discussion of the Infection-Defense Hypothesis -- Cancer – Childhood Acute Leukemia -- Environmental Toxicants and Susceptibility to Infection -- Reducing the Prevalence of Immune-Based Chronic Disease.
Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes,multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus. Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction. Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions. This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students.
Publisher:
Humana Press : Imprint: Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781617798122
Subject:
Medicine.
Immunology.
Toxicology.
Biomedicine.
Pharmacology/Toxicology.
Immunology.
Molecular Medicine.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Introduction to Immunotoxicity -- The Environment-Immune Route to Chronic Disease -- Asthma and Respiratory Allergies -- Cutaneous Allergies -- Food Allergies -- Factors Involved in Onset of Type1 Diabetes -- Rheumatoid Arthritis -- Environment, Immune Dysfunction and Systemic Lupus Erythematosus -- Multiple Sclerosis, Alzheimer’s Disease and Inflammation: A Hypothetical View -- Immune Dysfunction in Autism Spectrum Disorders -- Atherosclerosis and Inflammatory Heart Disease -- Inflammatory Bowel Disease and Celiac Disease: Environmental Risks Factors and Consequences -- COPD and Other Inflammatory Diseases of the Lung: Focus on AhR signaling -- Environment, the Immune System, and Depression: An Integrative Review and Discussion of the Infection-Defense Hypothesis -- Cancer – Childhood Acute Leukemia -- Environmental Toxicants and Susceptibility to Infection -- Reducing the Prevalence of Immune-Based Chronic Disease.
Physical Description:
XV, 451 p. 19 illus., 10 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-61779-812-2
Publication Date:
2012.
Title:
Immunotoxicity, Immune Dysfunction, and Chronic Disease edited by Rodney R. Dietert, Robert W. Luebke.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Dietert, Rodney R. editor.
Luebke, Robert W. editor.
SpringerLink (Online service)
General Notes:
Introduction to Immunotoxicity -- The Environment-Immune Route to Chronic Disease -- Asthma and Respiratory Allergies -- Cutaneous Allergies -- Food Allergies -- Factors Involved in Onset of Type1 Diabetes -- Rheumatoid Arthritis -- Environment, Immune Dysfunction and Systemic Lupus Erythematosus -- Multiple Sclerosis, Alzheimer’s Disease and Inflammation: A Hypothetical View -- Immune Dysfunction in Autism Spectrum Disorders -- Atherosclerosis and Inflammatory Heart Disease -- Inflammatory Bowel Disease and Celiac Disease: Environmental Risks Factors and Consequences -- COPD and Other Inflammatory Diseases of the Lung: Focus on AhR signaling -- Environment, the Immune System, and Depression: An Integrative Review and Discussion of the Infection-Defense Hypothesis -- Cancer – Childhood Acute Leukemia -- Environmental Toxicants and Susceptibility to Infection -- Reducing the Prevalence of Immune-Based Chronic Disease.
Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes,multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus. Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction. Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions. This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students.
Publisher:
Humana Press : Imprint: Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781617798122
Subject:
Medicine.
Immunology.
Toxicology.
Biomedicine.
Pharmacology/Toxicology.
Immunology.
Molecular Medicine.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Introduction to Immunotoxicity -- The Environment-Immune Route to Chronic Disease -- Asthma and Respiratory Allergies -- Cutaneous Allergies -- Food Allergies -- Factors Involved in Onset of Type1 Diabetes -- Rheumatoid Arthritis -- Environment, Immune Dysfunction and Systemic Lupus Erythematosus -- Multiple Sclerosis, Alzheimer’s Disease and Inflammation: A Hypothetical View -- Immune Dysfunction in Autism Spectrum Disorders -- Atherosclerosis and Inflammatory Heart Disease -- Inflammatory Bowel Disease and Celiac Disease: Environmental Risks Factors and Consequences -- COPD and Other Inflammatory Diseases of the Lung: Focus on AhR signaling -- Environment, the Immune System, and Depression: An Integrative Review and Discussion of the Infection-Defense Hypothesis -- Cancer – Childhood Acute Leukemia -- Environmental Toxicants and Susceptibility to Infection -- Reducing the Prevalence of Immune-Based Chronic Disease.
Physical Description:
XV, 451 p. 19 illus., 10 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-61779-812-2
Publication Date:
2012.
Title:
Toxicants in Food Packaging and Household Plastics Exposure and Health Risks to Consumers / edited by Suzanne M. Snedeker.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Snedeker, Suzanne M. editor.
SpringerLink (Online service)
General Notes:
Human Health Effects of Bisphenol A -- Phthalates in Food Packaging, Consumer Products, and Indoor Environments -- Brominated Flame Retardants and Their Replacements in Food Packaging and Household Products – Uses, Human Exposure, and Health Effects -- Nanoparticles in Polymer Nanocomposite Food Contact Materials – Uses, Potential Release, and Emerging Toxicological Concerns -- The Alkylphenols Nonylphenol and Octylphenol in Food Contact Materials and Household Products – Exposure and Health Risk Considerations -- Benzophenone UV-Photoinitiators Used in Food Packaging – Potential for Human Exposure and Health Risk Considerations -- Perfluorinated Compounds in Food Contact Materials -- Antimony in Food Contact Materials and Household Plastics – Uses, Exposure and Health Risk Considerations -- Lead in Household Products -- Methylnaphthalene in Food Packaging and Cadmium in Food Packaging and Household Items – Overview of Exposure, Toxicology, Regulatory Aspects, and Research Needs -- Food Contact Materials: Practices, Agencies and Challenges. .
This book serves as a comprehensive resource on toxicants that can be released from food packaging materials and household plastics. Chapters include sources and levels of chemical exposure, known and suspected health effects, and the identification of data gaps with recommendations for further research. In addition, regulatory approaches and risk assessment challenges in the United States and Europe are discussed. Chapters cover both the more widely known chemicals that can migrate from food packaging (bisphenol A, perfluorinated chemicals), and household plastics (lead, phthalates, brominated flame retardants), as well as chemicals that are just entering use in food packaging (nanomaterials in polymer food packaging), and chemicals recently identified as migrating from food packaging to food stuffs (phthalates, benzophenones, antimony, methylnaphthalene, and the alkylphenols nonylphenol and octylphenol). Chapters on phthalates and brominated flame retardants discuss challenges that arise with the use of replacement chemicals. The health effect sections of chapters have drawn on a wide variety of toxicological endpoints, and recommend approaches to better assess toxicological risks in vulnerable human populations. Reflecting the global nature of our food supply and household consumer goods, contributions have been drawn from international experts. A wide range of scientists will find this book to be useful, including toxicologists, environmental health scientists, food scientists, and regulators.
Publisher:
Springer London : Imprint: Springer,
Publication Place:
London :
ISBN:
9781447165002
Subject:
Medicine.
Cancer research.
Pharmacology.
Food -- Biotechnology.
Chemical engineering.
Endocrinology.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Food Science.
Cancer research.
Endocrinology.
Industrial Chemistry/Chemical Engineering.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Human Health Effects of Bisphenol A -- Phthalates in Food Packaging, Consumer Products, and Indoor Environments -- Brominated Flame Retardants and Their Replacements in Food Packaging and Household Products – Uses, Human Exposure, and Health Effects -- Nanoparticles in Polymer Nanocomposite Food Contact Materials – Uses, Potential Release, and Emerging Toxicological Concerns -- The Alkylphenols Nonylphenol and Octylphenol in Food Contact Materials and Household Products – Exposure and Health Risk Considerations -- Benzophenone UV-Photoinitiators Used in Food Packaging – Potential for Human Exposure and Health Risk Considerations -- Perfluorinated Compounds in Food Contact Materials -- Antimony in Food Contact Materials and Household Plastics – Uses, Exposure and Health Risk Considerations -- Lead in Household Products -- Methylnaphthalene in Food Packaging and Cadmium in Food Packaging and Household Items – Overview of Exposure, Toxicology, Regulatory Aspects, and Research Needs -- Food Contact Materials: Practices, Agencies and Challenges. .
Physical Description:
X, 310 p. 20 illus., 7 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4471-6500-2
Publication Date:
2014.
Title:
Toxicants in Food Packaging and Household Plastics Exposure and Health Risks to Consumers / edited by Suzanne M. Snedeker.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Snedeker, Suzanne M. editor.
SpringerLink (Online service)
General Notes:
Human Health Effects of Bisphenol A -- Phthalates in Food Packaging, Consumer Products, and Indoor Environments -- Brominated Flame Retardants and Their Replacements in Food Packaging and Household Products – Uses, Human Exposure, and Health Effects -- Nanoparticles in Polymer Nanocomposite Food Contact Materials – Uses, Potential Release, and Emerging Toxicological Concerns -- The Alkylphenols Nonylphenol and Octylphenol in Food Contact Materials and Household Products – Exposure and Health Risk Considerations -- Benzophenone UV-Photoinitiators Used in Food Packaging – Potential for Human Exposure and Health Risk Considerations -- Perfluorinated Compounds in Food Contact Materials -- Antimony in Food Contact Materials and Household Plastics – Uses, Exposure and Health Risk Considerations -- Lead in Household Products -- Methylnaphthalene in Food Packaging and Cadmium in Food Packaging and Household Items – Overview of Exposure, Toxicology, Regulatory Aspects, and Research Needs -- Food Contact Materials: Practices, Agencies and Challenges. .
This book serves as a comprehensive resource on toxicants that can be released from food packaging materials and household plastics. Chapters include sources and levels of chemical exposure, known and suspected health effects, and the identification of data gaps with recommendations for further research. In addition, regulatory approaches and risk assessment challenges in the United States and Europe are discussed. Chapters cover both the more widely known chemicals that can migrate from food packaging (bisphenol A, perfluorinated chemicals), and household plastics (lead, phthalates, brominated flame retardants), as well as chemicals that are just entering use in food packaging (nanomaterials in polymer food packaging), and chemicals recently identified as migrating from food packaging to food stuffs (phthalates, benzophenones, antimony, methylnaphthalene, and the alkylphenols nonylphenol and octylphenol). Chapters on phthalates and brominated flame retardants discuss challenges that arise with the use of replacement chemicals. The health effect sections of chapters have drawn on a wide variety of toxicological endpoints, and recommend approaches to better assess toxicological risks in vulnerable human populations. Reflecting the global nature of our food supply and household consumer goods, contributions have been drawn from international experts. A wide range of scientists will find this book to be useful, including toxicologists, environmental health scientists, food scientists, and regulators.
Publisher:
Springer London : Imprint: Springer,
Publication Place:
London :
ISBN:
9781447165002
Subject:
Medicine.
Cancer research.
Pharmacology.
Food -- Biotechnology.
Chemical engineering.
Endocrinology.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Food Science.
Cancer research.
Endocrinology.
Industrial Chemistry/Chemical Engineering.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Human Health Effects of Bisphenol A -- Phthalates in Food Packaging, Consumer Products, and Indoor Environments -- Brominated Flame Retardants and Their Replacements in Food Packaging and Household Products – Uses, Human Exposure, and Health Effects -- Nanoparticles in Polymer Nanocomposite Food Contact Materials – Uses, Potential Release, and Emerging Toxicological Concerns -- The Alkylphenols Nonylphenol and Octylphenol in Food Contact Materials and Household Products – Exposure and Health Risk Considerations -- Benzophenone UV-Photoinitiators Used in Food Packaging – Potential for Human Exposure and Health Risk Considerations -- Perfluorinated Compounds in Food Contact Materials -- Antimony in Food Contact Materials and Household Plastics – Uses, Exposure and Health Risk Considerations -- Lead in Household Products -- Methylnaphthalene in Food Packaging and Cadmium in Food Packaging and Household Items – Overview of Exposure, Toxicology, Regulatory Aspects, and Research Needs -- Food Contact Materials: Practices, Agencies and Challenges. .
Physical Description:
X, 310 p. 20 illus., 7 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4471-6500-2
Publication Date:
2014.
Title:
Metabonomics and Gut Microbiota in Nutrition and Disease edited by Sunil Kochhar, François-Pierre Martin.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Kochhar, Sunil. editor.
Martin, François-Pierre. editor.
SpringerLink (Online service)
General Notes:
Introduction to Metabolomics in systems biology research -- Metabolomics in clinical practice.-Adopting multivariate non-parametric tools to determine genotype-phenotype interactions in health and disease -- Metabolomics in Translational Research for Personalized Medicine and Nutrition -- Can we use Metabolomics to Understand Changes to Gut Microbiota Populations and Function? A Nutritional Perspective -- Automated annotation of microbial and human flavonoid derived metabolites -- Metabonomics in neonatal and paediatric research: Studying and modulating gut functional ecology for optimal growth and development -- Metabolomics and Milk: the Development of the Microbiota in Breast Fed Infants -- Metabonomics and gut microbial paradigm in healthy ageing -- Roles of herbal medicine in modulating gut microbiota associated with health and diseases -- Gut microbiota and metabolic diseases: from pathogenesis to therapeutic perspective -- Role of microbiota in regulating host lipid metabolism and disease risk -- Role of the Gut Microbiota in Maintaining GI Health: Highlights on Inflammatory Bowel Disease -- Deciphering the gut microbial contribution to the aetiology of autism development -- The Modulation of Drug Efficacy and Toxicity by the Gut Microbiome -- Understanding the benefits of bariatric surgery on gut physiology: implications for obesity, type 2 diabetes and cardiovascular disease.
This book provides a comprehensive overview of metabonomics and gut microbiota research from molecular analysis to population-based global health considerations. The topics include the discussion of the applications in relation to metabonomics and gut microbiota in nutritional research, in health and disease and a review of future therapeutical, nutraceutical and clinical applications. It also examines the translatability of systems biology approaches into applied clinical research and to patient health and nutrition. The rise in multifactorial disorders, the lack of understanding of the molecular processes at play and the needs for disease prediction in asymptomatic conditions are some of the many questions that system biology approaches are well suited to address. Achieving this goal lies in our ability to model and understand the complex web of interactions between genetics, metabolism, environmental factors, and gut microbiota. Being the most densely populated microbial ecosystem on earth, gut microbiota co-evolved as a key component of human biology, essentially extending the physiological definition of humans. Major advances in microbiome research have shown that the contribution of the intestinal microbiota to the overall health status of the host has been so far underestimated. Human host gut microbial interaction is one of the most significant human health considerations of the present day with relevance for both prevention of disease via microbiota-oriented environmental protection as well as strategies for new therapeutic approaches using microbiota as targets and/or biomarkers. In many aspects, humans are not a complete and fully healthy organism without their appropriate microbiological components. Increasingly, scientific evidence identifies gut microbiota as a key biological interface between human genetics and environmental conditions encompassing nutrition. Microbiota dysbiosis or variation in metabolic activity has been associated with metabolic deregulation (e.g. obesity, inflammatory bowel disease), disease risk factor (e.g. coronary heart disease) and even the aetiology of various pathologies (e.g. autism, cancer), although causal role into impaired metabolism still needs to be established. Metabonomics and Gut Microbiota in Nutrition and Disease serves as a handbook for postgraduate students, researchers in life sciences or health sciences, scientists in academic and industrial environments working in application areas as diverse as health, disease, nutrition, microbial research and human clinical medicine. .
Publisher:
Springer London : Imprint: Springer,
Publication Place:
London :
ISBN:
9781447165392
Subject:
Medicine.
Medical microbiology.
Pharmacology.
Food -- Biotechnology.
Nutrition.
Biomedicine.
Pharmacology/Toxicology.
Medical microbiology.
Food Science.
Nutrition.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Introduction to Metabolomics in systems biology research -- Metabolomics in clinical practice.-Adopting multivariate non-parametric tools to determine genotype-phenotype interactions in health and disease -- Metabolomics in Translational Research for Personalized Medicine and Nutrition -- Can we use Metabolomics to Understand Changes to Gut Microbiota Populations and Function? A Nutritional Perspective -- Automated annotation of microbial and human flavonoid derived metabolites -- Metabonomics in neonatal and paediatric research: Studying and modulating gut functional ecology for optimal growth and development -- Metabolomics and Milk: the Development of the Microbiota in Breast Fed Infants -- Metabonomics and gut microbial paradigm in healthy ageing -- Roles of herbal medicine in modulating gut microbiota associated with health and diseases -- Gut microbiota and metabolic diseases: from pathogenesis to therapeutic perspective -- Role of microbiota in regulating host lipid metabolism and disease risk -- Role of the Gut Microbiota in Maintaining GI Health: Highlights on Inflammatory Bowel Disease -- Deciphering the gut microbial contribution to the aetiology of autism development -- The Modulation of Drug Efficacy and Toxicity by the Gut Microbiome -- Understanding the benefits of bariatric surgery on gut physiology: implications for obesity, type 2 diabetes and cardiovascular disease.
Physical Description:
XVI, 375 p. 54 illus., 43 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4471-6539-2
Publication Date:
2015.
Title:
Metabonomics and Gut Microbiota in Nutrition and Disease edited by Sunil Kochhar, François-Pierre Martin.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Kochhar, Sunil. editor.
Martin, François-Pierre. editor.
SpringerLink (Online service)
General Notes:
Introduction to Metabolomics in systems biology research -- Metabolomics in clinical practice.-Adopting multivariate non-parametric tools to determine genotype-phenotype interactions in health and disease -- Metabolomics in Translational Research for Personalized Medicine and Nutrition -- Can we use Metabolomics to Understand Changes to Gut Microbiota Populations and Function? A Nutritional Perspective -- Automated annotation of microbial and human flavonoid derived metabolites -- Metabonomics in neonatal and paediatric research: Studying and modulating gut functional ecology for optimal growth and development -- Metabolomics and Milk: the Development of the Microbiota in Breast Fed Infants -- Metabonomics and gut microbial paradigm in healthy ageing -- Roles of herbal medicine in modulating gut microbiota associated with health and diseases -- Gut microbiota and metabolic diseases: from pathogenesis to therapeutic perspective -- Role of microbiota in regulating host lipid metabolism and disease risk -- Role of the Gut Microbiota in Maintaining GI Health: Highlights on Inflammatory Bowel Disease -- Deciphering the gut microbial contribution to the aetiology of autism development -- The Modulation of Drug Efficacy and Toxicity by the Gut Microbiome -- Understanding the benefits of bariatric surgery on gut physiology: implications for obesity, type 2 diabetes and cardiovascular disease.
This book provides a comprehensive overview of metabonomics and gut microbiota research from molecular analysis to population-based global health considerations. The topics include the discussion of the applications in relation to metabonomics and gut microbiota in nutritional research, in health and disease and a review of future therapeutical, nutraceutical and clinical applications. It also examines the translatability of systems biology approaches into applied clinical research and to patient health and nutrition. The rise in multifactorial disorders, the lack of understanding of the molecular processes at play and the needs for disease prediction in asymptomatic conditions are some of the many questions that system biology approaches are well suited to address. Achieving this goal lies in our ability to model and understand the complex web of interactions between genetics, metabolism, environmental factors, and gut microbiota. Being the most densely populated microbial ecosystem on earth, gut microbiota co-evolved as a key component of human biology, essentially extending the physiological definition of humans. Major advances in microbiome research have shown that the contribution of the intestinal microbiota to the overall health status of the host has been so far underestimated. Human host gut microbial interaction is one of the most significant human health considerations of the present day with relevance for both prevention of disease via microbiota-oriented environmental protection as well as strategies for new therapeutic approaches using microbiota as targets and/or biomarkers. In many aspects, humans are not a complete and fully healthy organism without their appropriate microbiological components. Increasingly, scientific evidence identifies gut microbiota as a key biological interface between human genetics and environmental conditions encompassing nutrition. Microbiota dysbiosis or variation in metabolic activity has been associated with metabolic deregulation (e.g. obesity, inflammatory bowel disease), disease risk factor (e.g. coronary heart disease) and even the aetiology of various pathologies (e.g. autism, cancer), although causal role into impaired metabolism still needs to be established. Metabonomics and Gut Microbiota in Nutrition and Disease serves as a handbook for postgraduate students, researchers in life sciences or health sciences, scientists in academic and industrial environments working in application areas as diverse as health, disease, nutrition, microbial research and human clinical medicine. .
Publisher:
Springer London : Imprint: Springer,
Publication Place:
London :
ISBN:
9781447165392
Subject:
Medicine.
Medical microbiology.
Pharmacology.
Food -- Biotechnology.
Nutrition.
Biomedicine.
Pharmacology/Toxicology.
Medical microbiology.
Food Science.
Nutrition.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Introduction to Metabolomics in systems biology research -- Metabolomics in clinical practice.-Adopting multivariate non-parametric tools to determine genotype-phenotype interactions in health and disease -- Metabolomics in Translational Research for Personalized Medicine and Nutrition -- Can we use Metabolomics to Understand Changes to Gut Microbiota Populations and Function? A Nutritional Perspective -- Automated annotation of microbial and human flavonoid derived metabolites -- Metabonomics in neonatal and paediatric research: Studying and modulating gut functional ecology for optimal growth and development -- Metabolomics and Milk: the Development of the Microbiota in Breast Fed Infants -- Metabonomics and gut microbial paradigm in healthy ageing -- Roles of herbal medicine in modulating gut microbiota associated with health and diseases -- Gut microbiota and metabolic diseases: from pathogenesis to therapeutic perspective -- Role of microbiota in regulating host lipid metabolism and disease risk -- Role of the Gut Microbiota in Maintaining GI Health: Highlights on Inflammatory Bowel Disease -- Deciphering the gut microbial contribution to the aetiology of autism development -- The Modulation of Drug Efficacy and Toxicity by the Gut Microbiome -- Understanding the benefits of bariatric surgery on gut physiology: implications for obesity, type 2 diabetes and cardiovascular disease.
Physical Description:
XVI, 375 p. 54 illus., 43 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4471-6539-2
Publication Date:
2015.
Title:
Trichloroethylene: Toxicity and Health Risks edited by Kathleen M. Gilbert, Sarah J. Blossom.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Gilbert, Kathleen M. editor.
Blossom, Sarah J. editor.
SpringerLink (Online service)
General Notes:
History of TCE -- Trichloroethylene and autoimmunity in human and animal.-Hypersensitivity Dermatitis and Hepatitis -- Trichloroethylene-induced oxidative stress and autoimmunity.-Brain and Behavioral Changes in Rodent Models -- Role of Trichloroethylene in Parkinson’s disease -- Neuroimmune effects of developmental TCE exposure -- Environmental sensitivity to trichloroethylene (TCE) in the developing heart -- Trichloroethylene and Cancer -- Epigenetic Alterations Due to Trichloroethylene -- Mathematical Modeling and Trichloroethylene .
A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity.
Publisher:
Springer London : Imprint: Springer,
Publication Place:
London :
ISBN:
9781447163114
Subject:
Medicine.
Immunology.
Molecular biology.
Pharmacology.
Medical biochemistry.
Epidemiology.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Epidemiology.
Molecular Medicine.
Immunology.
Medical Biochemistry.
Environmental health.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
History of TCE -- Trichloroethylene and autoimmunity in human and animal.-Hypersensitivity Dermatitis and Hepatitis -- Trichloroethylene-induced oxidative stress and autoimmunity.-Brain and Behavioral Changes in Rodent Models -- Role of Trichloroethylene in Parkinson’s disease -- Neuroimmune effects of developmental TCE exposure -- Environmental sensitivity to trichloroethylene (TCE) in the developing heart -- Trichloroethylene and Cancer -- Epigenetic Alterations Due to Trichloroethylene -- Mathematical Modeling and Trichloroethylene .
Physical Description:
X, 245 p. 23 illus., 13 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4471-6311-4
Publication Date:
2014.
Title:
Trichloroethylene: Toxicity and Health Risks edited by Kathleen M. Gilbert, Sarah J. Blossom.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Gilbert, Kathleen M. editor.
Blossom, Sarah J. editor.
SpringerLink (Online service)
General Notes:
History of TCE -- Trichloroethylene and autoimmunity in human and animal.-Hypersensitivity Dermatitis and Hepatitis -- Trichloroethylene-induced oxidative stress and autoimmunity.-Brain and Behavioral Changes in Rodent Models -- Role of Trichloroethylene in Parkinson’s disease -- Neuroimmune effects of developmental TCE exposure -- Environmental sensitivity to trichloroethylene (TCE) in the developing heart -- Trichloroethylene and Cancer -- Epigenetic Alterations Due to Trichloroethylene -- Mathematical Modeling and Trichloroethylene .
A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. Discussion will focus on different kinds of modeling and how they may be used to predict functional consequences and to dissect the contribution of different mechanistic pathways, including potential mechanisms of action for trichloroethylene toxicity in different organ systems. It will explore the role of epigenetic alterations in trichloroethylene toxicity, this provides important mechanistic information and may also provide the basis for intervention therapy. Chapters will also explain how the risks from trichloroethylene exposure may be greater in certain populations based on genetic predisposition, age of exposure and co-exposure to other chemicals With contributions from international experts in the field, Trichloroethylene: Toxicity and Health Risks is an essential resource for researchers and clinicians in toxicology, immunology, medicine and public health as well as industry and government regulatory scientists involved in safety and health protection and epidemiologists, highlighting the need for interdisciplinary cooperation in solving issues of environmental toxicity.
Publisher:
Springer London : Imprint: Springer,
Publication Place:
London :
ISBN:
9781447163114
Subject:
Medicine.
Immunology.
Molecular biology.
Pharmacology.
Medical biochemistry.
Epidemiology.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Epidemiology.
Molecular Medicine.
Immunology.
Medical Biochemistry.
Environmental health.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
History of TCE -- Trichloroethylene and autoimmunity in human and animal.-Hypersensitivity Dermatitis and Hepatitis -- Trichloroethylene-induced oxidative stress and autoimmunity.-Brain and Behavioral Changes in Rodent Models -- Role of Trichloroethylene in Parkinson’s disease -- Neuroimmune effects of developmental TCE exposure -- Environmental sensitivity to trichloroethylene (TCE) in the developing heart -- Trichloroethylene and Cancer -- Epigenetic Alterations Due to Trichloroethylene -- Mathematical Modeling and Trichloroethylene .
Physical Description:
X, 245 p. 23 illus., 13 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4471-6311-4
Publication Date:
2014.
Title:
Air Pollution and Health Effects edited by Srikanth S. Nadadur, John W. Hollingsworth.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Nadadur, Srikanth S. editor.
Hollingsworth, John W. editor.
SpringerLink (Online service)
General Notes:
Reactive Ambient Particles -- Impacts of Air Pollution on Reproductive Health -- Air Pollution and Pregnancy Outcomes -- Air Pollution and Asthma -- Air pollution and chronic obstructive airway disease- Airborne Carcinogens – Mechanisms of Cancer -- Molecular epidemiology focused on airborne carcinogens -- Diabetes and metabolic syndrome -- Air Pollution, Lipids and Atherosclerosis -- Particulate Air Pollution and CNS Health.-Innate and adaptive immunity -- Genetics -- Urban Air Pollution and Health in Developing Countries -- Using Science to Shape Policy.
Exposure to ambient air pollutants, both indoors and outdoors has been associated with the exacerbation and also in the etiology of diverse human diseases. This book offers an overview of our current understanding of air pollution health risks and how this knowledge is being used in the regulatory, therapeutic intervention measures to protect the public health and reduce the disease burden caused by acute and long-term exposure to air pollutants. Air Pollution and Health Effects provides readers with a comprehensive understanding of air pollution health risks, morbidity and the global disease burden, whilst also delivering critical review on state of the art research so as to gain a fundamental understanding of the biological mechanisms involved in the etiology of air pollution-induced diseases. Chapters range from pregnancy outcomes and pre-term birth, carcinogens in the ambient aerosol and the health consequences of indoor biomass burning. Special emphasis is placed on regional and local air pollution and its impact on global health along with suitable preventive and interventional measures. With contributions from international experts in the field this volume is a valuable guide for researchers and clinicians in toxicology, medicine and public health as well as industry and government regulatory scientists involved in health protection.
Publisher:
Springer London : Imprint: Springer,
Publication Place:
London :
ISBN:
9781447166696
Subject:
Medicine.
Pharmacology.
Metabolic diseases.
Respiratory organs -- Diseases.
Epidemiology.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Epidemiology.
Metabolic Diseases.
Pneumology/Respiratory System.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Reactive Ambient Particles -- Impacts of Air Pollution on Reproductive Health -- Air Pollution and Pregnancy Outcomes -- Air Pollution and Asthma -- Air pollution and chronic obstructive airway disease- Airborne Carcinogens – Mechanisms of Cancer -- Molecular epidemiology focused on airborne carcinogens -- Diabetes and metabolic syndrome -- Air Pollution, Lipids and Atherosclerosis -- Particulate Air Pollution and CNS Health.-Innate and adaptive immunity -- Genetics -- Urban Air Pollution and Health in Developing Countries -- Using Science to Shape Policy.
Physical Description:
XV, 439 p. 60 illus., 39 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4471-6669-6
Publication Date:
2015.
Title:
Air Pollution and Health Effects edited by Srikanth S. Nadadur, John W. Hollingsworth.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Nadadur, Srikanth S. editor.
Hollingsworth, John W. editor.
SpringerLink (Online service)
General Notes:
Reactive Ambient Particles -- Impacts of Air Pollution on Reproductive Health -- Air Pollution and Pregnancy Outcomes -- Air Pollution and Asthma -- Air pollution and chronic obstructive airway disease- Airborne Carcinogens – Mechanisms of Cancer -- Molecular epidemiology focused on airborne carcinogens -- Diabetes and metabolic syndrome -- Air Pollution, Lipids and Atherosclerosis -- Particulate Air Pollution and CNS Health.-Innate and adaptive immunity -- Genetics -- Urban Air Pollution and Health in Developing Countries -- Using Science to Shape Policy.
Exposure to ambient air pollutants, both indoors and outdoors has been associated with the exacerbation and also in the etiology of diverse human diseases. This book offers an overview of our current understanding of air pollution health risks and how this knowledge is being used in the regulatory, therapeutic intervention measures to protect the public health and reduce the disease burden caused by acute and long-term exposure to air pollutants. Air Pollution and Health Effects provides readers with a comprehensive understanding of air pollution health risks, morbidity and the global disease burden, whilst also delivering critical review on state of the art research so as to gain a fundamental understanding of the biological mechanisms involved in the etiology of air pollution-induced diseases. Chapters range from pregnancy outcomes and pre-term birth, carcinogens in the ambient aerosol and the health consequences of indoor biomass burning. Special emphasis is placed on regional and local air pollution and its impact on global health along with suitable preventive and interventional measures. With contributions from international experts in the field this volume is a valuable guide for researchers and clinicians in toxicology, medicine and public health as well as industry and government regulatory scientists involved in health protection.
Publisher:
Springer London : Imprint: Springer,
Publication Place:
London :
ISBN:
9781447166696
Subject:
Medicine.
Pharmacology.
Metabolic diseases.
Respiratory organs -- Diseases.
Epidemiology.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Epidemiology.
Metabolic Diseases.
Pneumology/Respiratory System.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Reactive Ambient Particles -- Impacts of Air Pollution on Reproductive Health -- Air Pollution and Pregnancy Outcomes -- Air Pollution and Asthma -- Air pollution and chronic obstructive airway disease- Airborne Carcinogens – Mechanisms of Cancer -- Molecular epidemiology focused on airborne carcinogens -- Diabetes and metabolic syndrome -- Air Pollution, Lipids and Atherosclerosis -- Particulate Air Pollution and CNS Health.-Innate and adaptive immunity -- Genetics -- Urban Air Pollution and Health in Developing Countries -- Using Science to Shape Policy.
Physical Description:
XV, 439 p. 60 illus., 39 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4471-6669-6
Publication Date:
2015.
Title:
Environmental Epigenetics edited by L. Joseph Su, Tung-chin Chiang.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Su, L. Joseph. editor.
Chiang, Tung-chin. editor.
SpringerLink (Online service)
General Notes:
What is Epigenetics -- Epidemiology of environment and health -- Technologies in measuring epigenetics -- Epigenetic changes in hormone related disease -- Epigenetic effects of environmental chemicals bisphenol a and phthalates -- Environmental epigenetics: a role in endocrine diseases? -- Pregnancy exposures determine risk of breast cancer in multiple generations of offspring -- Environmental epigenetics and obesity – evidences from animal to epidemiologic studies -- Environmental toxicants, epigenetics and cancer -- Aging, genes, environment and epigenetics -- Epigenetics: The link between nature and nurture -- Gene-Environment Interactions in Human Health -- Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships -- Conclusions: Lessons from epigenetic research: the impact of environmental stress can be accumulated and resulted in diverse outcome.
This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations, and specific disease risks such as cancer cardiovascular diseases, and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry, and laboratories and as a textbook for graduate level environmental health courses.
Publisher:
Springer London : Imprint: Springer,
Publication Place:
London :
ISBN:
9781447166788
Subject:
Medicine.
Human genetics.
Pharmacology.
Epidemiology.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Human genetics.
Epidemiology.
Medicine/Public Health, general.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
What is Epigenetics -- Epidemiology of environment and health -- Technologies in measuring epigenetics -- Epigenetic changes in hormone related disease -- Epigenetic effects of environmental chemicals bisphenol a and phthalates -- Environmental epigenetics: a role in endocrine diseases? -- Pregnancy exposures determine risk of breast cancer in multiple generations of offspring -- Environmental epigenetics and obesity – evidences from animal to epidemiologic studies -- Environmental toxicants, epigenetics and cancer -- Aging, genes, environment and epigenetics -- Epigenetics: The link between nature and nurture -- Gene-Environment Interactions in Human Health -- Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships -- Conclusions: Lessons from epigenetic research: the impact of environmental stress can be accumulated and resulted in diverse outcome.
Physical Description:
XIII, 321 p. 38 illus., 33 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4471-6678-8
Publication Date:
2015.
Title:
Environmental Epigenetics edited by L. Joseph Su, Tung-chin Chiang.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Su, L. Joseph. editor.
Chiang, Tung-chin. editor.
SpringerLink (Online service)
General Notes:
What is Epigenetics -- Epidemiology of environment and health -- Technologies in measuring epigenetics -- Epigenetic changes in hormone related disease -- Epigenetic effects of environmental chemicals bisphenol a and phthalates -- Environmental epigenetics: a role in endocrine diseases? -- Pregnancy exposures determine risk of breast cancer in multiple generations of offspring -- Environmental epigenetics and obesity – evidences from animal to epidemiologic studies -- Environmental toxicants, epigenetics and cancer -- Aging, genes, environment and epigenetics -- Epigenetics: The link between nature and nurture -- Gene-Environment Interactions in Human Health -- Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships -- Conclusions: Lessons from epigenetic research: the impact of environmental stress can be accumulated and resulted in diverse outcome.
This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations, and specific disease risks such as cancer cardiovascular diseases, and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry, and laboratories and as a textbook for graduate level environmental health courses.
Publisher:
Springer London : Imprint: Springer,
Publication Place:
London :
ISBN:
9781447166788
Subject:
Medicine.
Human genetics.
Pharmacology.
Epidemiology.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Human genetics.
Epidemiology.
Medicine/Public Health, general.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
What is Epigenetics -- Epidemiology of environment and health -- Technologies in measuring epigenetics -- Epigenetic changes in hormone related disease -- Epigenetic effects of environmental chemicals bisphenol a and phthalates -- Environmental epigenetics: a role in endocrine diseases? -- Pregnancy exposures determine risk of breast cancer in multiple generations of offspring -- Environmental epigenetics and obesity – evidences from animal to epidemiologic studies -- Environmental toxicants, epigenetics and cancer -- Aging, genes, environment and epigenetics -- Epigenetics: The link between nature and nurture -- Gene-Environment Interactions in Human Health -- Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships -- Conclusions: Lessons from epigenetic research: the impact of environmental stress can be accumulated and resulted in diverse outcome.
Physical Description:
XIII, 321 p. 38 illus., 33 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4471-6678-8
Publication Date:
2015.
Title:
Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances edited by Jamie C. DeWitt.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
DeWitt, Jamie C. editor.
SpringerLink (Online service)
General Notes:
Perfluorinated compounds: An overview -- Analysis of PFASs in biological tissues and fluids -- PFASs in the general population -- PFAS Biomonitoring in Higher Exposed Populations -- Perfluorinated Alkyl Acids in Wildlife -- Metabolism and Pharmacokinetics -- Metabolic EffectsPFAS -- Developmental Toxicity -- Neurotoxicity -- Immunotoxicity of Perfluoroalkylated Compounds -- Effects of PFOA on Endocrine-related Systems -- Carcinogenicity of Perfluoroalkyl Compounds -- Epidemiological Findings -- Dosimetric Anchoring of Toxicological Studies -- Human Health Risk Assessment of Perfluoroalkyl Acids -- Systematic Review, An Illustration of Increased Transparency in a Framework for Evaluating Immunotoxicity Associated with PFOA and PFOS Exposure -- Toxicology data for alternative “short-chain” fluorinated substances -- Conclusions and recommendations. .
This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of metabolism and toxicological effects by organ system/developmental stage, and aspects of PFAS toxicity that are driving PFAS research and regulatory oversight. Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances provides critical assessments of the most controversial topics surrounding toxicological evaluation of PFASs to give readers an expert perspective on the issues. Emphasis is placed on the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health. This book will be a useful resource for toxicologists, environmental chemists, risk assessors, and researchers with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319155180
Subject:
Medicine.
Pharmacology.
Environmental health.
Ecotoxicology.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Ecotoxicology.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Perfluorinated compounds: An overview -- Analysis of PFASs in biological tissues and fluids -- PFASs in the general population -- PFAS Biomonitoring in Higher Exposed Populations -- Perfluorinated Alkyl Acids in Wildlife -- Metabolism and Pharmacokinetics -- Metabolic EffectsPFAS -- Developmental Toxicity -- Neurotoxicity -- Immunotoxicity of Perfluoroalkylated Compounds -- Effects of PFOA on Endocrine-related Systems -- Carcinogenicity of Perfluoroalkyl Compounds -- Epidemiological Findings -- Dosimetric Anchoring of Toxicological Studies -- Human Health Risk Assessment of Perfluoroalkyl Acids -- Systematic Review, An Illustration of Increased Transparency in a Framework for Evaluating Immunotoxicity Associated with PFOA and PFOS Exposure -- Toxicology data for alternative “short-chain” fluorinated substances -- Conclusions and recommendations. .
Physical Description:
XIII, 495 p. 49 illus., 15 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-15518-0
Publication Date:
2015.
Title:
Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances edited by Jamie C. DeWitt.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
DeWitt, Jamie C. editor.
SpringerLink (Online service)
General Notes:
Perfluorinated compounds: An overview -- Analysis of PFASs in biological tissues and fluids -- PFASs in the general population -- PFAS Biomonitoring in Higher Exposed Populations -- Perfluorinated Alkyl Acids in Wildlife -- Metabolism and Pharmacokinetics -- Metabolic EffectsPFAS -- Developmental Toxicity -- Neurotoxicity -- Immunotoxicity of Perfluoroalkylated Compounds -- Effects of PFOA on Endocrine-related Systems -- Carcinogenicity of Perfluoroalkyl Compounds -- Epidemiological Findings -- Dosimetric Anchoring of Toxicological Studies -- Human Health Risk Assessment of Perfluoroalkyl Acids -- Systematic Review, An Illustration of Increased Transparency in a Framework for Evaluating Immunotoxicity Associated with PFOA and PFOS Exposure -- Toxicology data for alternative “short-chain” fluorinated substances -- Conclusions and recommendations. .
This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of metabolism and toxicological effects by organ system/developmental stage, and aspects of PFAS toxicity that are driving PFAS research and regulatory oversight. Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances provides critical assessments of the most controversial topics surrounding toxicological evaluation of PFASs to give readers an expert perspective on the issues. Emphasis is placed on the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health. This book will be a useful resource for toxicologists, environmental chemists, risk assessors, and researchers with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319155180
Subject:
Medicine.
Pharmacology.
Environmental health.
Ecotoxicology.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Ecotoxicology.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Perfluorinated compounds: An overview -- Analysis of PFASs in biological tissues and fluids -- PFASs in the general population -- PFAS Biomonitoring in Higher Exposed Populations -- Perfluorinated Alkyl Acids in Wildlife -- Metabolism and Pharmacokinetics -- Metabolic EffectsPFAS -- Developmental Toxicity -- Neurotoxicity -- Immunotoxicity of Perfluoroalkylated Compounds -- Effects of PFOA on Endocrine-related Systems -- Carcinogenicity of Perfluoroalkyl Compounds -- Epidemiological Findings -- Dosimetric Anchoring of Toxicological Studies -- Human Health Risk Assessment of Perfluoroalkyl Acids -- Systematic Review, An Illustration of Increased Transparency in a Framework for Evaluating Immunotoxicity Associated with PFOA and PFOS Exposure -- Toxicology data for alternative “short-chain” fluorinated substances -- Conclusions and recommendations. .
Physical Description:
XIII, 495 p. 49 illus., 15 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-15518-0
Publication Date:
2015.
Title:
Tryptophan Metabolism: Implications for Biological Processes, Health and Disease edited by Atilla Engin, Ayse Basak Engin.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Engin, Atilla. editor.
Engin, Ayse Basak. editor.
SpringerLink (Online service)
General Notes:
TRYPTOPHAN RELATED SIGNALING MOLECULES: TARGETS AND FUNCTIONS -- TRYPTOPHAN AND CELL DEATH -- TRYPTOPHAN AND NITRIC OXIDE IN ALLERGY.-Tryptophan metabolites: A microbial perspective -- THE ROLE OF L-TRYPTOPHAN KYNURENINE PATHWAY METABOLISM IN VARIOUS INFECTIOUS DISEASES: FOCUS ON INDOLEAMINE 2,3-DIOXYGENASE 1 -- EVALUATION OF TRYPTOPHAN METABOLISM IN CHRONIC IMMUNE ACTIVATION -- DIABETES AND TRYPTOPHAN METABOLISM -- 3-HYDROXYKYNURENIC ACID AND TYPE 2 DIABETES: IMPLICATIONS FOR AGING, OBESITY, DEPRESSION, PARKINSON’S DISEASE AND SCHIZOPHRENIA -- THERAPEUTICAL IMPLICATIONS OF MELATONIN IN ALZHEIMER´S AND PARKINSON´S DISEASES -- TRYPTOPHAN METABOLISM AND SLEEP -- TRYPTOPHAN IN MOLECULAR HEMATOPOIESIS -- NIGHT-SHIFTS AND MELATONIN: RELEVANCE TO AGE AND BREAST CANCER -- CHEMOTHERAPEUTIC AGENTS IN CANCER TREATMENT AND TRYPTOPHAN METABOLISM.-INDOLEAMINE 2,3-DIOXYGENASE-COMPETENT REGULATORY DENDRITIC CELLS AND THEIR ROLE IN ALLOIMMUNE REGULATION AND TRANSPLANT IMMUNE TOLERANCE -- WINE FLAVOR AND TRYPTOPHAN .
This book discusses the relationship between cellular immunity and tryptophan metabolism, as well as its products, serotonin and melatonin, in the development of several diseases and reappraises the common signal transduction pathways of the neurodegenerative diseases, carcinogenesis, immune tolerance, inflammation, hypersensitivity reactions, neuropsychiatric disorders, in addition to bacterial tryptophan biosynthesis and novel antimicrobials. Tryptophan Metabolism: Implications for Biological Processes, Health and Disease presents fundamental information on tryptophan related metabolic pathways and metabolites, implications of these products for specific biological processes, diseases and conditions. This book focuses on effects of tryptophan metabolites on human health and will appeal to researchers, clinicians and students within this field.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319156309
Subject:
Medicine.
Immunology.
Molecular biology.
Pharmacology.
Metabolic diseases.
Biomedicine.
Pharmacology/Toxicology.
Molecular Medicine.
Metabolic Diseases.
Immunology.
Biomedicine general.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
TRYPTOPHAN RELATED SIGNALING MOLECULES: TARGETS AND FUNCTIONS -- TRYPTOPHAN AND CELL DEATH -- TRYPTOPHAN AND NITRIC OXIDE IN ALLERGY.-Tryptophan metabolites: A microbial perspective -- THE ROLE OF L-TRYPTOPHAN KYNURENINE PATHWAY METABOLISM IN VARIOUS INFECTIOUS DISEASES: FOCUS ON INDOLEAMINE 2,3-DIOXYGENASE 1 -- EVALUATION OF TRYPTOPHAN METABOLISM IN CHRONIC IMMUNE ACTIVATION -- DIABETES AND TRYPTOPHAN METABOLISM -- 3-HYDROXYKYNURENIC ACID AND TYPE 2 DIABETES: IMPLICATIONS FOR AGING, OBESITY, DEPRESSION, PARKINSON’S DISEASE AND SCHIZOPHRENIA -- THERAPEUTICAL IMPLICATIONS OF MELATONIN IN ALZHEIMER´S AND PARKINSON´S DISEASES -- TRYPTOPHAN METABOLISM AND SLEEP -- TRYPTOPHAN IN MOLECULAR HEMATOPOIESIS -- NIGHT-SHIFTS AND MELATONIN: RELEVANCE TO AGE AND BREAST CANCER -- CHEMOTHERAPEUTIC AGENTS IN CANCER TREATMENT AND TRYPTOPHAN METABOLISM.-INDOLEAMINE 2,3-DIOXYGENASE-COMPETENT REGULATORY DENDRITIC CELLS AND THEIR ROLE IN ALLOIMMUNE REGULATION AND TRANSPLANT IMMUNE TOLERANCE -- WINE FLAVOR AND TRYPTOPHAN .
Physical Description:
XI, 382 p. 21 illus., 17 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-15630-9
Publication Date:
2015.
Title:
Tryptophan Metabolism: Implications for Biological Processes, Health and Disease edited by Atilla Engin, Ayse Basak Engin.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Engin, Atilla. editor.
Engin, Ayse Basak. editor.
SpringerLink (Online service)
General Notes:
TRYPTOPHAN RELATED SIGNALING MOLECULES: TARGETS AND FUNCTIONS -- TRYPTOPHAN AND CELL DEATH -- TRYPTOPHAN AND NITRIC OXIDE IN ALLERGY.-Tryptophan metabolites: A microbial perspective -- THE ROLE OF L-TRYPTOPHAN KYNURENINE PATHWAY METABOLISM IN VARIOUS INFECTIOUS DISEASES: FOCUS ON INDOLEAMINE 2,3-DIOXYGENASE 1 -- EVALUATION OF TRYPTOPHAN METABOLISM IN CHRONIC IMMUNE ACTIVATION -- DIABETES AND TRYPTOPHAN METABOLISM -- 3-HYDROXYKYNURENIC ACID AND TYPE 2 DIABETES: IMPLICATIONS FOR AGING, OBESITY, DEPRESSION, PARKINSON’S DISEASE AND SCHIZOPHRENIA -- THERAPEUTICAL IMPLICATIONS OF MELATONIN IN ALZHEIMER´S AND PARKINSON´S DISEASES -- TRYPTOPHAN METABOLISM AND SLEEP -- TRYPTOPHAN IN MOLECULAR HEMATOPOIESIS -- NIGHT-SHIFTS AND MELATONIN: RELEVANCE TO AGE AND BREAST CANCER -- CHEMOTHERAPEUTIC AGENTS IN CANCER TREATMENT AND TRYPTOPHAN METABOLISM.-INDOLEAMINE 2,3-DIOXYGENASE-COMPETENT REGULATORY DENDRITIC CELLS AND THEIR ROLE IN ALLOIMMUNE REGULATION AND TRANSPLANT IMMUNE TOLERANCE -- WINE FLAVOR AND TRYPTOPHAN .
This book discusses the relationship between cellular immunity and tryptophan metabolism, as well as its products, serotonin and melatonin, in the development of several diseases and reappraises the common signal transduction pathways of the neurodegenerative diseases, carcinogenesis, immune tolerance, inflammation, hypersensitivity reactions, neuropsychiatric disorders, in addition to bacterial tryptophan biosynthesis and novel antimicrobials. Tryptophan Metabolism: Implications for Biological Processes, Health and Disease presents fundamental information on tryptophan related metabolic pathways and metabolites, implications of these products for specific biological processes, diseases and conditions. This book focuses on effects of tryptophan metabolites on human health and will appeal to researchers, clinicians and students within this field.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319156309
Subject:
Medicine.
Immunology.
Molecular biology.
Pharmacology.
Metabolic diseases.
Biomedicine.
Pharmacology/Toxicology.
Molecular Medicine.
Metabolic Diseases.
Immunology.
Biomedicine general.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
TRYPTOPHAN RELATED SIGNALING MOLECULES: TARGETS AND FUNCTIONS -- TRYPTOPHAN AND CELL DEATH -- TRYPTOPHAN AND NITRIC OXIDE IN ALLERGY.-Tryptophan metabolites: A microbial perspective -- THE ROLE OF L-TRYPTOPHAN KYNURENINE PATHWAY METABOLISM IN VARIOUS INFECTIOUS DISEASES: FOCUS ON INDOLEAMINE 2,3-DIOXYGENASE 1 -- EVALUATION OF TRYPTOPHAN METABOLISM IN CHRONIC IMMUNE ACTIVATION -- DIABETES AND TRYPTOPHAN METABOLISM -- 3-HYDROXYKYNURENIC ACID AND TYPE 2 DIABETES: IMPLICATIONS FOR AGING, OBESITY, DEPRESSION, PARKINSON’S DISEASE AND SCHIZOPHRENIA -- THERAPEUTICAL IMPLICATIONS OF MELATONIN IN ALZHEIMER´S AND PARKINSON´S DISEASES -- TRYPTOPHAN METABOLISM AND SLEEP -- TRYPTOPHAN IN MOLECULAR HEMATOPOIESIS -- NIGHT-SHIFTS AND MELATONIN: RELEVANCE TO AGE AND BREAST CANCER -- CHEMOTHERAPEUTIC AGENTS IN CANCER TREATMENT AND TRYPTOPHAN METABOLISM.-INDOLEAMINE 2,3-DIOXYGENASE-COMPETENT REGULATORY DENDRITIC CELLS AND THEIR ROLE IN ALLOIMMUNE REGULATION AND TRANSPLANT IMMUNE TOLERANCE -- WINE FLAVOR AND TRYPTOPHAN .
Physical Description:
XI, 382 p. 21 illus., 17 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-15630-9
Publication Date:
2015.
Title:
Translational Toxicology Defining a New Therapeutic Discipline / edited by Claude L. Hughes, Michael D. Waters.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Hughes, Claude L. editor.
Waters, Michael D. editor.
SpringerLink (Online service)
General Notes:
I.Introduction -- The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline -- The Role of Toxicokinetics and Toxicodynamics in Developmental and Translational Toxicology -- II.Toxicant Modes of Action and Biomarkers -- Mutational Effects -- Ligand-Mediated Toxicology: Characterization and Translational Prospects -- Effects of Environmentally Acquired Heavy Metals and Nutrients on the Epigenome and Phenotype -- Fetal Imaging and Effects of Exposures on Growth and Function -- III.Developmental Risks of Exposures and Potential Translational Toxicology Therapeutics -- Ovarian Toxicity of Environmental Contaminants: 50 Shades of Grey -- The “Toxic” Effects of a Perinatal Obesogenic Environment: Maternal Obesity and Impacts on Future Generations -- The Role of Environmental Exposures in Preterm Birth -- The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development and Chronic Physical Aggression: Prospects for Early Protective Interventions -- Coffee Health Effects from Early Fetal Development through Childhood and Adolescence.
Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319274492
Subject:
Medicine.
Pharmacology.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Edition:
1st ed. 2016.
Contents:
I.Introduction -- The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline -- The Role of Toxicokinetics and Toxicodynamics in Developmental and Translational Toxicology -- II.Toxicant Modes of Action and Biomarkers -- Mutational Effects -- Ligand-Mediated Toxicology: Characterization and Translational Prospects -- Effects of Environmentally Acquired Heavy Metals and Nutrients on the Epigenome and Phenotype -- Fetal Imaging and Effects of Exposures on Growth and Function -- III.Developmental Risks of Exposures and Potential Translational Toxicology Therapeutics -- Ovarian Toxicity of Environmental Contaminants: 50 Shades of Grey -- The “Toxic” Effects of a Perinatal Obesogenic Environment: Maternal Obesity and Impacts on Future Generations -- The Role of Environmental Exposures in Preterm Birth -- The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development and Chronic Physical Aggression: Prospects for Early Protective Interventions -- Coffee Health Effects from Early Fetal Development through Childhood and Adolescence.
Physical Description:
XV, 380 p. 32 illus., 12 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-27449-2
Publication Date:
2016.
Title:
Translational Toxicology Defining a New Therapeutic Discipline / edited by Claude L. Hughes, Michael D. Waters.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Hughes, Claude L. editor.
Waters, Michael D. editor.
SpringerLink (Online service)
General Notes:
I.Introduction -- The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline -- The Role of Toxicokinetics and Toxicodynamics in Developmental and Translational Toxicology -- II.Toxicant Modes of Action and Biomarkers -- Mutational Effects -- Ligand-Mediated Toxicology: Characterization and Translational Prospects -- Effects of Environmentally Acquired Heavy Metals and Nutrients on the Epigenome and Phenotype -- Fetal Imaging and Effects of Exposures on Growth and Function -- III.Developmental Risks of Exposures and Potential Translational Toxicology Therapeutics -- Ovarian Toxicity of Environmental Contaminants: 50 Shades of Grey -- The “Toxic” Effects of a Perinatal Obesogenic Environment: Maternal Obesity and Impacts on Future Generations -- The Role of Environmental Exposures in Preterm Birth -- The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development and Chronic Physical Aggression: Prospects for Early Protective Interventions -- Coffee Health Effects from Early Fetal Development through Childhood and Adolescence.
Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319274492
Subject:
Medicine.
Pharmacology.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Edition:
1st ed. 2016.
Contents:
I.Introduction -- The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline -- The Role of Toxicokinetics and Toxicodynamics in Developmental and Translational Toxicology -- II.Toxicant Modes of Action and Biomarkers -- Mutational Effects -- Ligand-Mediated Toxicology: Characterization and Translational Prospects -- Effects of Environmentally Acquired Heavy Metals and Nutrients on the Epigenome and Phenotype -- Fetal Imaging and Effects of Exposures on Growth and Function -- III.Developmental Risks of Exposures and Potential Translational Toxicology Therapeutics -- Ovarian Toxicity of Environmental Contaminants: 50 Shades of Grey -- The “Toxic” Effects of a Perinatal Obesogenic Environment: Maternal Obesity and Impacts on Future Generations -- The Role of Environmental Exposures in Preterm Birth -- The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development and Chronic Physical Aggression: Prospects for Early Protective Interventions -- Coffee Health Effects from Early Fetal Development through Childhood and Adolescence.
Physical Description:
XV, 380 p. 32 illus., 12 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-27449-2
Publication Date:
2016.
Title:
Environmental Determinants of Human Health edited by Jozef M. Pacyna, Elisabeth G. Pacyna.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Pacyna, Jozef M. editor.
Pacyna, Elisabeth G. editor.
SpringerLink (Online service)
General Notes:
Sources and Fluxes of harmful metals -- Exposure to environmental hazards and effects on chronic disease -- Human exposure to pollutants and their health endpoints. The Arctic perspective -- Effects of pollutant exposure on human health as studied with selected EU projects -- Organic metal species as risk factor for neurological diseases -- Integrated Assessment of Policies for Reducing Health Impacts Caused by Air Pollution -- Monetary and non-monetary measures of health benefits from exposure reduction -- Capturing the health effects of environmental and industrial policy in a macroeconomic model -- Transition to a Low Carbon Economy; Impacts to Health and the Environment -- Unmasking environmental health Zorros: the need for involvement of real risk communication experts for two-way and problem-solving communication approaches -- Citizen participation approaches in environmental health -- Environment and Health Research Funded by the European Union (EU) Research Framework Programmes: Increasing Scientific Knowledge and Building a Solid Evidence-Base for Policy Making.
Polluted air and contaminated food and water are major causes of human health deterioration, but public health policy has long struggled to effectively address these concerns. This timely book—written for a wide audience of policy makers, researchers, and general readers—synthesizes what we already know about environmental hazards, identifies the gaps in our knowledge, and provides a roadmap for reducing human exposure to environmental pollution. With contributions from leading experts, Environmental Determinants of Human Health examines numerous pollutants, both inorganic and organic, in the context of their human health impacts. Individual chapters explore exposure pathways, macroeconomic impacts of human health deterioration, technological and non-technological methods for reducing exposures, monetary and non-monetary benefits from exposure reduction, and risk communication and awareness, including citizen participation approaches. This volume is a crucial text for policy makers requiring scientific justification for the development of new environmental regulations, scientists researching public health and environmental contamination, and members of the public interested in human health issues.
Publisher:
Springer International Publishing : Imprint: Springer,
Publication Place:
Cham :
ISBN:
9783319431420
Subject:
Medicine.
Pharmacology.
Public health.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Public health.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Sources and Fluxes of harmful metals -- Exposure to environmental hazards and effects on chronic disease -- Human exposure to pollutants and their health endpoints. The Arctic perspective -- Effects of pollutant exposure on human health as studied with selected EU projects -- Organic metal species as risk factor for neurological diseases -- Integrated Assessment of Policies for Reducing Health Impacts Caused by Air Pollution -- Monetary and non-monetary measures of health benefits from exposure reduction -- Capturing the health effects of environmental and industrial policy in a macroeconomic model -- Transition to a Low Carbon Economy; Impacts to Health and the Environment -- Unmasking environmental health Zorros: the need for involvement of real risk communication experts for two-way and problem-solving communication approaches -- Citizen participation approaches in environmental health -- Environment and Health Research Funded by the European Union (EU) Research Framework Programmes: Increasing Scientific Knowledge and Building a Solid Evidence-Base for Policy Making.
Physical Description:
XIV, 270 p. 32 illus., 15 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-43142-0
Publication Date:
2016.
Title:
Environmental Determinants of Human Health edited by Jozef M. Pacyna, Elisabeth G. Pacyna.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Pacyna, Jozef M. editor.
Pacyna, Elisabeth G. editor.
SpringerLink (Online service)
General Notes:
Sources and Fluxes of harmful metals -- Exposure to environmental hazards and effects on chronic disease -- Human exposure to pollutants and their health endpoints. The Arctic perspective -- Effects of pollutant exposure on human health as studied with selected EU projects -- Organic metal species as risk factor for neurological diseases -- Integrated Assessment of Policies for Reducing Health Impacts Caused by Air Pollution -- Monetary and non-monetary measures of health benefits from exposure reduction -- Capturing the health effects of environmental and industrial policy in a macroeconomic model -- Transition to a Low Carbon Economy; Impacts to Health and the Environment -- Unmasking environmental health Zorros: the need for involvement of real risk communication experts for two-way and problem-solving communication approaches -- Citizen participation approaches in environmental health -- Environment and Health Research Funded by the European Union (EU) Research Framework Programmes: Increasing Scientific Knowledge and Building a Solid Evidence-Base for Policy Making.
Polluted air and contaminated food and water are major causes of human health deterioration, but public health policy has long struggled to effectively address these concerns. This timely book—written for a wide audience of policy makers, researchers, and general readers—synthesizes what we already know about environmental hazards, identifies the gaps in our knowledge, and provides a roadmap for reducing human exposure to environmental pollution. With contributions from leading experts, Environmental Determinants of Human Health examines numerous pollutants, both inorganic and organic, in the context of their human health impacts. Individual chapters explore exposure pathways, macroeconomic impacts of human health deterioration, technological and non-technological methods for reducing exposures, monetary and non-monetary benefits from exposure reduction, and risk communication and awareness, including citizen participation approaches. This volume is a crucial text for policy makers requiring scientific justification for the development of new environmental regulations, scientists researching public health and environmental contamination, and members of the public interested in human health issues.
Publisher:
Springer International Publishing : Imprint: Springer,
Publication Place:
Cham :
ISBN:
9783319431420
Subject:
Medicine.
Pharmacology.
Public health.
Environmental health.
Biomedicine.
Pharmacology/Toxicology.
Environmental health.
Public health.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Sources and Fluxes of harmful metals -- Exposure to environmental hazards and effects on chronic disease -- Human exposure to pollutants and their health endpoints. The Arctic perspective -- Effects of pollutant exposure on human health as studied with selected EU projects -- Organic metal species as risk factor for neurological diseases -- Integrated Assessment of Policies for Reducing Health Impacts Caused by Air Pollution -- Monetary and non-monetary measures of health benefits from exposure reduction -- Capturing the health effects of environmental and industrial policy in a macroeconomic model -- Transition to a Low Carbon Economy; Impacts to Health and the Environment -- Unmasking environmental health Zorros: the need for involvement of real risk communication experts for two-way and problem-solving communication approaches -- Citizen participation approaches in environmental health -- Environment and Health Research Funded by the European Union (EU) Research Framework Programmes: Increasing Scientific Knowledge and Building a Solid Evidence-Base for Policy Making.
Physical Description:
XIV, 270 p. 32 illus., 15 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-43142-0
Publication Date:
2016.
Title:
Essential and Non-essential Metals Carcinogenesis, Prevention and Cancer Therapeutics / edited by Anuradha Mudipalli, Judith T. Zelikoff.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Mudipalli, Anuradha. editor.
Zelikoff, Judith T. editor.
SpringerLink (Online service)
General Notes:
Calcium channels and pumps important during lactation as potential targets for breast cancer -- Tumor development through the Mg2+nifying glass -- Selenium: roles in cancer prevention and therapies -- Zinc and Zinc-Dependent Proteins in Cancer adn Chemotherapeutics -- Arsenic Carcinogenesis -- Cadmium Carcinogenesis and Mechanistic Insights -- Molecular Mechanisms of Chromium-Induced Carcinogenesis -- Mechanisms of Nickel Carcinogenesis -- Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal-based Drugs.
This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319554488
Subject:
Medicine.
Cancer research.
Molecular biology.
Biomedicine.
Cancer research.
Molecular Medicine.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Calcium channels and pumps important during lactation as potential targets for breast cancer -- Tumor development through the Mg2+nifying glass -- Selenium: roles in cancer prevention and therapies -- Zinc and Zinc-Dependent Proteins in Cancer adn Chemotherapeutics -- Arsenic Carcinogenesis -- Cadmium Carcinogenesis and Mechanistic Insights -- Molecular Mechanisms of Chromium-Induced Carcinogenesis -- Mechanisms of Nickel Carcinogenesis -- Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal-based Drugs.
Physical Description:
XII, 228 p. 74 illus., 65 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-55448-8
Publication Date:
2017.
Title:
Essential and Non-essential Metals Carcinogenesis, Prevention and Cancer Therapeutics / edited by Anuradha Mudipalli, Judith T. Zelikoff.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Mudipalli, Anuradha. editor.
Zelikoff, Judith T. editor.
SpringerLink (Online service)
General Notes:
Calcium channels and pumps important during lactation as potential targets for breast cancer -- Tumor development through the Mg2+nifying glass -- Selenium: roles in cancer prevention and therapies -- Zinc and Zinc-Dependent Proteins in Cancer adn Chemotherapeutics -- Arsenic Carcinogenesis -- Cadmium Carcinogenesis and Mechanistic Insights -- Molecular Mechanisms of Chromium-Induced Carcinogenesis -- Mechanisms of Nickel Carcinogenesis -- Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal-based Drugs.
This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319554488
Subject:
Medicine.
Cancer research.
Molecular biology.
Biomedicine.
Cancer research.
Molecular Medicine.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Calcium channels and pumps important during lactation as potential targets for breast cancer -- Tumor development through the Mg2+nifying glass -- Selenium: roles in cancer prevention and therapies -- Zinc and Zinc-Dependent Proteins in Cancer adn Chemotherapeutics -- Arsenic Carcinogenesis -- Cadmium Carcinogenesis and Mechanistic Insights -- Molecular Mechanisms of Chromium-Induced Carcinogenesis -- Mechanisms of Nickel Carcinogenesis -- Application of Metallomics and Metalloproteomics for Understanding the Molecular Mechanisms of Action of Metal-based Drugs.
Physical Description:
XII, 228 p. 74 illus., 65 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-55448-8
Publication Date:
2017.
Title:
Immunopathology in Toxicology and Drug Development Volume 1, Immunobiology, Investigative Techniques, and Special Studies / edited by George A. Parker.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Parker, George A. editor.
SpringerLink (Online service)
General Notes:
Basic Immunobiology -- Cells of the Immune System -- Signaling and effector molecules in immunity -- Development of immune system organs -- Aging of immune system organs -- Flow cytometry and immunophenotyping in drug development -- Pathology evaluation for detection of immunomodulation -- Enhanced immunohistopathology -- Clinical Pathology Assays in Immunopathology -- Application of immunohistochemistry in toxicologic pathology of the hematolymphoid system -- Morphometry and stereology in immunopathology -- Molecular techniques in immunopathology -- Current issues in developmental immunotoxicity -- The Murine local lymph node assay -- Host Resistance assays for efficacy and immunotoxicology safety evaluations. .
This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. .
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319473772
Subject:
Medicine.
Immunology.
Pharmaceutical technology.
Medical biochemistry.
Pathology.
Medicine & Public Health.
Pathology.
Immunology.
Pharmaceutical Sciences/Technology.
Medical Biochemistry.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Basic Immunobiology -- Cells of the Immune System -- Signaling and effector molecules in immunity -- Development of immune system organs -- Aging of immune system organs -- Flow cytometry and immunophenotyping in drug development -- Pathology evaluation for detection of immunomodulation -- Enhanced immunohistopathology -- Clinical Pathology Assays in Immunopathology -- Application of immunohistochemistry in toxicologic pathology of the hematolymphoid system -- Morphometry and stereology in immunopathology -- Molecular techniques in immunopathology -- Current issues in developmental immunotoxicity -- The Murine local lymph node assay -- Host Resistance assays for efficacy and immunotoxicology safety evaluations. .
Physical Description:
XXII, 670 p. 255 illus., 250 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-47377-2
Publication Date:
2017.
Title:
Immunopathology in Toxicology and Drug Development Volume 1, Immunobiology, Investigative Techniques, and Special Studies / edited by George A. Parker.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Parker, George A. editor.
SpringerLink (Online service)
General Notes:
Basic Immunobiology -- Cells of the Immune System -- Signaling and effector molecules in immunity -- Development of immune system organs -- Aging of immune system organs -- Flow cytometry and immunophenotyping in drug development -- Pathology evaluation for detection of immunomodulation -- Enhanced immunohistopathology -- Clinical Pathology Assays in Immunopathology -- Application of immunohistochemistry in toxicologic pathology of the hematolymphoid system -- Morphometry and stereology in immunopathology -- Molecular techniques in immunopathology -- Current issues in developmental immunotoxicity -- The Murine local lymph node assay -- Host Resistance assays for efficacy and immunotoxicology safety evaluations. .
This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. .
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319473772
Subject:
Medicine.
Immunology.
Pharmaceutical technology.
Medical biochemistry.
Pathology.
Medicine & Public Health.
Pathology.
Immunology.
Pharmaceutical Sciences/Technology.
Medical Biochemistry.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Basic Immunobiology -- Cells of the Immune System -- Signaling and effector molecules in immunity -- Development of immune system organs -- Aging of immune system organs -- Flow cytometry and immunophenotyping in drug development -- Pathology evaluation for detection of immunomodulation -- Enhanced immunohistopathology -- Clinical Pathology Assays in Immunopathology -- Application of immunohistochemistry in toxicologic pathology of the hematolymphoid system -- Morphometry and stereology in immunopathology -- Molecular techniques in immunopathology -- Current issues in developmental immunotoxicity -- The Murine local lymph node assay -- Host Resistance assays for efficacy and immunotoxicology safety evaluations. .
Physical Description:
XXII, 670 p. 255 illus., 250 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-47377-2
Publication Date:
2017.
Title:
Immunopathology in Toxicology and Drug Development Volume 2, Organ Systems / edited by George A. Parker.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Parker, George A. editor.
SpringerLink (Online service)
General Notes:
Thymus -- Spleen -- Lymph node -- Mucosa-associated lymphoid tissues -- Immunopathology of the nervous system -- Immunopathology of the urinary system -- Immunopathology of the hepatobiliary system -- Immunopathology of the respiratory system -- Immunopathology of the cardiovascular system -- Immunopathology of the male reproductive tract -- Immunopathology of the female reproductive tract and mammary gland -- Immunopathology of the musculoskeletal system -- Immunopathology of the endocrine system -- Ocular Immunopathology -- Immunopathology of Drug and Toxin-related Skin Reactions.
This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. .
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319473857
Subject:
Medicine.
Immunology.
Pharmaceutical technology.
Medical biochemistry.
Pathology.
Medicine & Public Health.
Pathology.
Immunology.
Pharmaceutical Sciences/Technology.
Medical Biochemistry.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Thymus -- Spleen -- Lymph node -- Mucosa-associated lymphoid tissues -- Immunopathology of the nervous system -- Immunopathology of the urinary system -- Immunopathology of the hepatobiliary system -- Immunopathology of the respiratory system -- Immunopathology of the cardiovascular system -- Immunopathology of the male reproductive tract -- Immunopathology of the female reproductive tract and mammary gland -- Immunopathology of the musculoskeletal system -- Immunopathology of the endocrine system -- Ocular Immunopathology -- Immunopathology of Drug and Toxin-related Skin Reactions.
Physical Description:
XXII, 826 p. 194 illus., 167 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-47385-7
Publication Date:
2017.
Title:
Immunopathology in Toxicology and Drug Development Volume 2, Organ Systems / edited by George A. Parker.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Parker, George A. editor.
SpringerLink (Online service)
General Notes:
Thymus -- Spleen -- Lymph node -- Mucosa-associated lymphoid tissues -- Immunopathology of the nervous system -- Immunopathology of the urinary system -- Immunopathology of the hepatobiliary system -- Immunopathology of the respiratory system -- Immunopathology of the cardiovascular system -- Immunopathology of the male reproductive tract -- Immunopathology of the female reproductive tract and mammary gland -- Immunopathology of the musculoskeletal system -- Immunopathology of the endocrine system -- Ocular Immunopathology -- Immunopathology of Drug and Toxin-related Skin Reactions.
This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. .
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319473857
Subject:
Medicine.
Immunology.
Pharmaceutical technology.
Medical biochemistry.
Pathology.
Medicine & Public Health.
Pathology.
Immunology.
Pharmaceutical Sciences/Technology.
Medical Biochemistry.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Thymus -- Spleen -- Lymph node -- Mucosa-associated lymphoid tissues -- Immunopathology of the nervous system -- Immunopathology of the urinary system -- Immunopathology of the hepatobiliary system -- Immunopathology of the respiratory system -- Immunopathology of the cardiovascular system -- Immunopathology of the male reproductive tract -- Immunopathology of the female reproductive tract and mammary gland -- Immunopathology of the musculoskeletal system -- Immunopathology of the endocrine system -- Ocular Immunopathology -- Immunopathology of Drug and Toxin-related Skin Reactions.
Physical Description:
XXII, 826 p. 194 illus., 167 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-47385-7
Publication Date:
2017.
Title:
Bone Toxicology edited by Susan Y. Smith, Aurore Varela, Rana Samadfam.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Smith, Susan Y. editor.
Varela, Aurore. editor.
Samadfam, Rana. editor.
SpringerLink (Online service)
General Notes:
Bone Toxicology in Preclinical Drug Testing -- Bone Physiology and Biology -- Study designs and Regulatory Considerations -- Specific Considerations for Bone Evaluations for Pediatric Therapeutics -- Bone Pharmacology and other models in Preclinical Drug Testing -- Methods in Bone Toxicology -- Biochemical Markers and Hormones -- Imaging -- Biomechanics -- Pathology and Histomorphometry -- Integrated System Toxicology -- Bone and Muscle -- Bone and Reproductive System -- Bone and Kidneys -- Bone and Energy Metabolism -- Bone and Immune System -- Bone and Central Nervous System -- Bone and Other Organs.
The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.
Publisher:
Springer International Publishing : Imprint: Springer,
Publication Place:
Cham :
ISBN:
9783319561929
Subject:
Medicine.
Pharmacology.
Pharmaceutical technology.
Animal models in research.
Biomedicine.
Pharmacology/Toxicology.
Pharmaceutical Sciences/Technology.
Animal Models.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Bone Toxicology in Preclinical Drug Testing -- Bone Physiology and Biology -- Study designs and Regulatory Considerations -- Specific Considerations for Bone Evaluations for Pediatric Therapeutics -- Bone Pharmacology and other models in Preclinical Drug Testing -- Methods in Bone Toxicology -- Biochemical Markers and Hormones -- Imaging -- Biomechanics -- Pathology and Histomorphometry -- Integrated System Toxicology -- Bone and Muscle -- Bone and Reproductive System -- Bone and Kidneys -- Bone and Energy Metabolism -- Bone and Immune System -- Bone and Central Nervous System -- Bone and Other Organs.
Physical Description:
XII, 474 p. 72 illus., 63 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-56192-9
Publication Date:
2017.
Title:
Bone Toxicology edited by Susan Y. Smith, Aurore Varela, Rana Samadfam.
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Author:
Smith, Susan Y. editor.
Varela, Aurore. editor.
Samadfam, Rana. editor.
SpringerLink (Online service)
General Notes:
Bone Toxicology in Preclinical Drug Testing -- Bone Physiology and Biology -- Study designs and Regulatory Considerations -- Specific Considerations for Bone Evaluations for Pediatric Therapeutics -- Bone Pharmacology and other models in Preclinical Drug Testing -- Methods in Bone Toxicology -- Biochemical Markers and Hormones -- Imaging -- Biomechanics -- Pathology and Histomorphometry -- Integrated System Toxicology -- Bone and Muscle -- Bone and Reproductive System -- Bone and Kidneys -- Bone and Energy Metabolism -- Bone and Immune System -- Bone and Central Nervous System -- Bone and Other Organs.
The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.
Publisher:
Springer International Publishing : Imprint: Springer,
Publication Place:
Cham :
ISBN:
9783319561929
Subject:
Medicine.
Pharmacology.
Pharmaceutical technology.
Animal models in research.
Biomedicine.
Pharmacology/Toxicology.
Pharmaceutical Sciences/Technology.
Animal Models.
Series:
Molecular and Integrative Toxicology,
Molecular and Integrative Toxicology,
Contents:
Bone Toxicology in Preclinical Drug Testing -- Bone Physiology and Biology -- Study designs and Regulatory Considerations -- Specific Considerations for Bone Evaluations for Pediatric Therapeutics -- Bone Pharmacology and other models in Preclinical Drug Testing -- Methods in Bone Toxicology -- Biochemical Markers and Hormones -- Imaging -- Biomechanics -- Pathology and Histomorphometry -- Integrated System Toxicology -- Bone and Muscle -- Bone and Reproductive System -- Bone and Kidneys -- Bone and Energy Metabolism -- Bone and Immune System -- Bone and Central Nervous System -- Bone and Other Organs.
Physical Description:
XII, 474 p. 72 illus., 63 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-56192-9
Publication Date:
2017.
Title:
Molecular and Multimodality Imaging in Cardiovascular Disease edited by Thomas H. Schindler, Richard T. George, Joao A.C. Lima.
Author:
Schindler, Thomas H. editor.
George, Richard T. editor.
Lima, Joao A.C. editor.
SpringerLink (Online service)
General Notes:
PET/MRI: Physics, Instrumentation, and Scanners -- Potential Role of Cardiac PET/MRI in Cardiovascular Disease - Initial Experience -- PET/MRI for Cardiac Imaging -- Technical Considerations -- Role of PET and MRI in Assessing Cardiac Sarcoidosis -- Myocardial Viability: Hibernating and Stunning Myocardium - underlying Pathophysiology -- Concepts of SPECT, PET and MRI in the assessment of myocardial viability leading to PET/MRI -- Adding T-1 Mapping and MRI for Myocardial Fibrosis Assessment -- Potential of PET/MRI in Assessment of Cardiovascular Plaque Burden and Activity -- CT in Assessing Coronary Morphology, Perfusion and Viability -- 3D Fusion Display of CT-Coronary Angiography and Scintigraphic Perfusion Imaging -- 3D Fusion Display of CT-Coronary Angiography and PET-Determined Myocardial Flow Reserve. Is it the Future? -- Adding CT-measurements of Coronary Artery Calcification to SPECT Perfusion Imaging for Risk Stratification -- Cardiac Risk Stratification in Heart Failure Patients - Combining Assessment of Myocardial Viability with Sympathetic Innervations.
This book provides the most up-to-date coverage of the combined use of imaging modalities in order to acquire important functional and morphological information on cardiovascular disease and enhance disease detection. The recent developments in PET/MRI, cardiac CT, PET/CT, and SPECT/CT and their impact on clinical practice are explained, and special attention is also devoted to imaging parameters and protocols for use in practice and research. The utility of multimodality imaging techniques for diagnosis and evaluation is discussed in the context of various clinical scenarios, including ischemic cardiomyopathy, myocarditis, myocardial fibrosis, cardiac sarcoidosis, and atherosclerotic plaque disease. Written by renowned researchers and clinicians, the book is an ideal concise reference on today’s most advanced imaging techniques. It will appeal to all clinicians, trainees, and technicians who are involved in the diagnosis and risk assessment of cardiovascular disease.
Publisher:
Springer International Publishing : Imprint: Springer,
Publication Place:
Cham :
ISBN:
9783319196114
Subject:
Medicine.
nuclear medicine.
Cardiac imaging.
Cardiology.
Medicine & Public Health.
Nuclear medicine.
Cardiac Imaging.
Cardiology.
Contents:
PET/MRI: Physics, Instrumentation, and Scanners -- Potential Role of Cardiac PET/MRI in Cardiovascular Disease - Initial Experience -- PET/MRI for Cardiac Imaging -- Technical Considerations -- Role of PET and MRI in Assessing Cardiac Sarcoidosis -- Myocardial Viability: Hibernating and Stunning Myocardium - underlying Pathophysiology -- Concepts of SPECT, PET and MRI in the assessment of myocardial viability leading to PET/MRI -- Adding T-1 Mapping and MRI for Myocardial Fibrosis Assessment -- Potential of PET/MRI in Assessment of Cardiovascular Plaque Burden and Activity -- CT in Assessing Coronary Morphology, Perfusion and Viability -- 3D Fusion Display of CT-Coronary Angiography and Scintigraphic Perfusion Imaging -- 3D Fusion Display of CT-Coronary Angiography and PET-Determined Myocardial Flow Reserve. Is it the Future? -- Adding CT-measurements of Coronary Artery Calcification to SPECT Perfusion Imaging for Risk Stratification -- Cardiac Risk Stratification in Heart Failure Patients - Combining Assessment of Myocardial Viability with Sympathetic Innervations.
Physical Description:
XI, 247 p. 88 illus., 71 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-19611-4
Publication Date:
2015.
Title:
Hematopathology Genomic Mechanisms of Neoplastic Diseases / edited by Domnita Crisan.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Crisan, Domnita.
SpringerLink (Online service)
General Notes:
<p>Chapter 1: Molecular techniques used in Hematopathology -- Chapter 2: Cytogenetics techniques used in Hematopathology -- Chapter 3: The molecular component of the new WHO classification of hematologic malignancies -- Chapter 4: Molecular pathology of pediatric acute leukemias -- Chapter 5: Molecular pathology of adult acute leukemias -- Chapter 6: Molecular pathology of lymphomas -- Chapter 7: Molecular pathology of chronic myeloproliferative neoplasms -- Chapter 8: Molecular pathology of CLL -- Chapter 9: Targeted therapy in hematologic malignancies -- Chapter 10: MicroRNAs in hematologic malignancies.</p>.
Hematopathology: Genomic Mechanisms of Neoplastic Diseases will keep physicians abreast of the rapid and complex changes in genomic medicine, as exemplified by the molecular pathology of hematologic malignancies. This timely volume will update physicians on the complexities of genomic lesions, as well as offer an integrated framework encompassing molecular diagnosis, the new WHO classification of hematologic neoplasms with focus on molecular pathology, prognostic value of molecular tests, and molecular monitoring of response to gene-targeted therapy. As such, it will be of great value to hematologists, oncologists, pathologists, internal medicine and pediatric specialists, as well as bioscientific staff and laboratorians in private hospitals and academic institutions.
Publisher:
Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781607612629
Subject:
Medicine.
Hematology.
Oncology.
Pathology.
Medicine & Public Health.
Pathology.
Hematology.
Molecular Medicine.
Oncology.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Edition:
1.
Contents:
<p>Chapter 1: Molecular techniques used in Hematopathology -- Chapter 2: Cytogenetics techniques used in Hematopathology -- Chapter 3: The molecular component of the new WHO classification of hematologic malignancies -- Chapter 4: Molecular pathology of pediatric acute leukemias -- Chapter 5: Molecular pathology of adult acute leukemias -- Chapter 6: Molecular pathology of lymphomas -- Chapter 7: Molecular pathology of chronic myeloproliferative neoplasms -- Chapter 8: Molecular pathology of CLL -- Chapter 9: Targeted therapy in hematologic malignancies -- Chapter 10: MicroRNAs in hematologic malignancies.</p>.
Physical Description:
XII, 360 p. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-1-60761-262-9
Publication Date:
2010.
Title:
Hematopathology Genomic Mechanisms of Neoplastic Diseases / edited by Domnita Crisan.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Crisan, Domnita.
SpringerLink (Online service)
General Notes:
<p>Chapter 1: Molecular techniques used in Hematopathology -- Chapter 2: Cytogenetics techniques used in Hematopathology -- Chapter 3: The molecular component of the new WHO classification of hematologic malignancies -- Chapter 4: Molecular pathology of pediatric acute leukemias -- Chapter 5: Molecular pathology of adult acute leukemias -- Chapter 6: Molecular pathology of lymphomas -- Chapter 7: Molecular pathology of chronic myeloproliferative neoplasms -- Chapter 8: Molecular pathology of CLL -- Chapter 9: Targeted therapy in hematologic malignancies -- Chapter 10: MicroRNAs in hematologic malignancies.</p>.
Hematopathology: Genomic Mechanisms of Neoplastic Diseases will keep physicians abreast of the rapid and complex changes in genomic medicine, as exemplified by the molecular pathology of hematologic malignancies. This timely volume will update physicians on the complexities of genomic lesions, as well as offer an integrated framework encompassing molecular diagnosis, the new WHO classification of hematologic neoplasms with focus on molecular pathology, prognostic value of molecular tests, and molecular monitoring of response to gene-targeted therapy. As such, it will be of great value to hematologists, oncologists, pathologists, internal medicine and pediatric specialists, as well as bioscientific staff and laboratorians in private hospitals and academic institutions.
Publisher:
Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781607612629
Subject:
Medicine.
Hematology.
Oncology.
Pathology.
Medicine & Public Health.
Pathology.
Hematology.
Molecular Medicine.
Oncology.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Edition:
1.
Contents:
<p>Chapter 1: Molecular techniques used in Hematopathology -- Chapter 2: Cytogenetics techniques used in Hematopathology -- Chapter 3: The molecular component of the new WHO classification of hematologic malignancies -- Chapter 4: Molecular pathology of pediatric acute leukemias -- Chapter 5: Molecular pathology of adult acute leukemias -- Chapter 6: Molecular pathology of lymphomas -- Chapter 7: Molecular pathology of chronic myeloproliferative neoplasms -- Chapter 8: Molecular pathology of CLL -- Chapter 9: Targeted therapy in hematologic malignancies -- Chapter 10: MicroRNAs in hematologic malignancies.</p>.
Physical Description:
XII, 360 p. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-1-60761-262-9
Publication Date:
2010.
Title:
Pharmacogenomic Testing in Current Clinical Practice Implementation in the Clinical Laboratory / edited by Alan H. B. Wu, Kiang-Teck J. Yeo.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Wu, Alan H. B.
Yeo, Kiang-Teck J.
SpringerLink (Online service)
General Notes:
While the basic principles of personalized medicine and pharmacogenomics has been covered by numerous texts, there are none to date that focuses on the specific tests themselves that are in current clinical practice and those that are being proposed for implementation in the near future. Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory focuses almost entirely on the specifics of each test that is needed to implement these tests into a clinical laboratory. This volume presents the first compilation of the tests currently in routine clinical use. The chapter authors of this unique and invaluable title comprise a range of renowned authorities and investigators who have conducted the essential clinical trials necessary to justify pharmacogenomic testing today. The book is divided into four parts: Basic Concepts, Specific Pharmacogenomic Targets, Drugs that Cause Delayed Hypersensitivity, and Miscellaneous Drugs. Each author provides a pharmacologic background on the target drug, the need for pharmacogenomic testing, and how results can be translated into clinical decisions. Where appropriate, case studies are given to illustrate typical clinical scenarios. An extensive bibliography is provided so that the reader can refer to the original studies. This well-designed resource will appeal to clinical laboratory directors who are contemplating or assigned the task of establishing a pharmacogenomics laboratory and a wide range of clinicians who must interpret results of testing. Focused and immensely useful, Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory is a timely and outstanding contribution to the literature and will be instrumental in defining this rapidly growing field.
Publisher:
Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781607612834
Subject:
Medicine.
Pathology.
Medicine & Public Health.
Pathology.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Physical Description:
XIV, 272p. 50 illus., 30 illus. in color. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-1-60761-283-4
Publication Date:
2011.
Title:
Pharmacogenomic Testing in Current Clinical Practice Implementation in the Clinical Laboratory / edited by Alan H. B. Wu, Kiang-Teck J. Yeo.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Wu, Alan H. B.
Yeo, Kiang-Teck J.
SpringerLink (Online service)
General Notes:
While the basic principles of personalized medicine and pharmacogenomics has been covered by numerous texts, there are none to date that focuses on the specific tests themselves that are in current clinical practice and those that are being proposed for implementation in the near future. Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory focuses almost entirely on the specifics of each test that is needed to implement these tests into a clinical laboratory. This volume presents the first compilation of the tests currently in routine clinical use. The chapter authors of this unique and invaluable title comprise a range of renowned authorities and investigators who have conducted the essential clinical trials necessary to justify pharmacogenomic testing today. The book is divided into four parts: Basic Concepts, Specific Pharmacogenomic Targets, Drugs that Cause Delayed Hypersensitivity, and Miscellaneous Drugs. Each author provides a pharmacologic background on the target drug, the need for pharmacogenomic testing, and how results can be translated into clinical decisions. Where appropriate, case studies are given to illustrate typical clinical scenarios. An extensive bibliography is provided so that the reader can refer to the original studies. This well-designed resource will appeal to clinical laboratory directors who are contemplating or assigned the task of establishing a pharmacogenomics laboratory and a wide range of clinicians who must interpret results of testing. Focused and immensely useful, Pharmacogenomic Testing in Current Clinical Practice: Implementation in the Clinical Laboratory is a timely and outstanding contribution to the literature and will be instrumental in defining this rapidly growing field.
Publisher:
Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781607612834
Subject:
Medicine.
Pathology.
Medicine & Public Health.
Pathology.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Physical Description:
XIV, 272p. 50 illus., 30 illus. in color. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-1-60761-283-4
Publication Date:
2011.
Title:
Exercise Genomics edited by Linda S. Pescatello, Stephen M. Roth.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Pescatello, Linda S.
Roth, Stephen M.
SpringerLink (Online service)
General Notes:
<p><b>Table of Contents:</b></p><p> </p><p><b>Preface -- </b><b>Foreward</b>: <b>Exercise, Fitness and Performance Genomics Poised to Make Significant Contributions to Health and Performance Traits.- </b><b>Fundamental Concepts in Exercise Genomics.- </b><b>Statistical and Methodological Considerations in Exercise Genomics -- </b><b>Can You Be Born a Couch Potato? The Genomic Regulation of Physical Activity -- </b><b>Interaction between Exercise and Genetics in Type 2 Diabetes Mellitus: An Epidemiological Perspective -- </b><b>The Interaction between Genetic Variation and Exercise and Physical Activity in the Determination of Body Composition and Obesity Status -- </b><b>Interactive Effects of Genetics and Acute Exercise and Exercise Training on Plasma Lipoprotein-Lipid and Blood Pressure Phenotypes -- </b><b>Genetic Aspects of Muscular Strength and Size.- </b> <b>Genomics of aerobic capacity and endurance performance – clinical implications.</b>- <b>A Synopsis of Exercise Genomics Research and a Vision for its Future Translation into Practice -- </b><b>Appendix I: Web-based Resources.</b></p><p>.
<p>Exercise Genomics encompasses the translation of exercise genomics into preventive medicine by presenting a broad overview of the rapidly expanding research examining the role of genetics and genomics within the areas of exercise performance and health-related physical activity. Leading researchers from a number of the key exercise genomics research groups around the world have been brought together to provide updates and analysis on the key discoveries of the past decade, as well as lend insights and opinion about the future of exercise genomics, especially within the contexts of translational and personalized medicine. Clinicians, researchers and health/fitness professionals will gain up-to-date background on the key findings and critical unanswered questions across several areas of exercise genomics, including performance, body composition, metabolism, and cardiovascular disease risk factors. Importantly, basic information on genomics, research methods, and statistics are presented within the context of exercise science to provide students and professionals with the foundation from which to fully engage with the more detailed chapters covering specific traits.</p><p>Exercise Genomics will be of great value to health/fitness professionals and graduate students in kinesiology, public health and sports medicine desiring to learn more about the translation of exercise genomics into preventive medicine.</p>
Publisher:
Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781607613558
Subject:
Medicine.
Metabolic diseases.
Sports medicine.
Medicine & Public Health.
Sports medicine.
Metabolic Diseases.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Edition:
1.
Contents:
<p><b>Table of Contents:</b></p><p> </p><p><b>Preface -- </b><b>Foreward</b>: <b>Exercise, Fitness and Performance Genomics Poised to Make Significant Contributions to Health and Performance Traits.- </b><b>Fundamental Concepts in Exercise Genomics.- </b><b>Statistical and Methodological Considerations in Exercise Genomics -- </b><b>Can You Be Born a Couch Potato? The Genomic Regulation of Physical Activity -- </b><b>Interaction between Exercise and Genetics in Type 2 Diabetes Mellitus: An Epidemiological Perspective -- </b><b>The Interaction between Genetic Variation and Exercise and Physical Activity in the Determination of Body Composition and Obesity Status -- </b><b>Interactive Effects of Genetics and Acute Exercise and Exercise Training on Plasma Lipoprotein-Lipid and Blood Pressure Phenotypes -- </b><b>Genetic Aspects of Muscular Strength and Size.- </b> <b>Genomics of aerobic capacity and endurance performance – clinical implications.</b>- <b>A Synopsis of Exercise Genomics Research and a Vision for its Future Translation into Practice -- </b><b>Appendix I: Web-based Resources.</b></p><p>.
Physical Description:
XX, 267p. 11 illus., 4 illus. in color. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-1-60761-355-8
Publication Date:
2011.
Title:
Exercise Genomics edited by Linda S. Pescatello, Stephen M. Roth.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Pescatello, Linda S.
Roth, Stephen M.
SpringerLink (Online service)
General Notes:
<p><b>Table of Contents:</b></p><p> </p><p><b>Preface -- </b><b>Foreward</b>: <b>Exercise, Fitness and Performance Genomics Poised to Make Significant Contributions to Health and Performance Traits.- </b><b>Fundamental Concepts in Exercise Genomics.- </b><b>Statistical and Methodological Considerations in Exercise Genomics -- </b><b>Can You Be Born a Couch Potato? The Genomic Regulation of Physical Activity -- </b><b>Interaction between Exercise and Genetics in Type 2 Diabetes Mellitus: An Epidemiological Perspective -- </b><b>The Interaction between Genetic Variation and Exercise and Physical Activity in the Determination of Body Composition and Obesity Status -- </b><b>Interactive Effects of Genetics and Acute Exercise and Exercise Training on Plasma Lipoprotein-Lipid and Blood Pressure Phenotypes -- </b><b>Genetic Aspects of Muscular Strength and Size.- </b> <b>Genomics of aerobic capacity and endurance performance – clinical implications.</b>- <b>A Synopsis of Exercise Genomics Research and a Vision for its Future Translation into Practice -- </b><b>Appendix I: Web-based Resources.</b></p><p>.
<p>Exercise Genomics encompasses the translation of exercise genomics into preventive medicine by presenting a broad overview of the rapidly expanding research examining the role of genetics and genomics within the areas of exercise performance and health-related physical activity. Leading researchers from a number of the key exercise genomics research groups around the world have been brought together to provide updates and analysis on the key discoveries of the past decade, as well as lend insights and opinion about the future of exercise genomics, especially within the contexts of translational and personalized medicine. Clinicians, researchers and health/fitness professionals will gain up-to-date background on the key findings and critical unanswered questions across several areas of exercise genomics, including performance, body composition, metabolism, and cardiovascular disease risk factors. Importantly, basic information on genomics, research methods, and statistics are presented within the context of exercise science to provide students and professionals with the foundation from which to fully engage with the more detailed chapters covering specific traits.</p><p>Exercise Genomics will be of great value to health/fitness professionals and graduate students in kinesiology, public health and sports medicine desiring to learn more about the translation of exercise genomics into preventive medicine.</p>
Publisher:
Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781607613558
Subject:
Medicine.
Metabolic diseases.
Sports medicine.
Medicine & Public Health.
Sports medicine.
Metabolic Diseases.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Edition:
1.
Contents:
<p><b>Table of Contents:</b></p><p> </p><p><b>Preface -- </b><b>Foreward</b>: <b>Exercise, Fitness and Performance Genomics Poised to Make Significant Contributions to Health and Performance Traits.- </b><b>Fundamental Concepts in Exercise Genomics.- </b><b>Statistical and Methodological Considerations in Exercise Genomics -- </b><b>Can You Be Born a Couch Potato? The Genomic Regulation of Physical Activity -- </b><b>Interaction between Exercise and Genetics in Type 2 Diabetes Mellitus: An Epidemiological Perspective -- </b><b>The Interaction between Genetic Variation and Exercise and Physical Activity in the Determination of Body Composition and Obesity Status -- </b><b>Interactive Effects of Genetics and Acute Exercise and Exercise Training on Plasma Lipoprotein-Lipid and Blood Pressure Phenotypes -- </b><b>Genetic Aspects of Muscular Strength and Size.- </b> <b>Genomics of aerobic capacity and endurance performance – clinical implications.</b>- <b>A Synopsis of Exercise Genomics Research and a Vision for its Future Translation into Practice -- </b><b>Appendix I: Web-based Resources.</b></p><p>.
Physical Description:
XX, 267p. 11 illus., 4 illus. in color. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-1-60761-355-8
Publication Date:
2011.
Title:
Targeted Therapies Mechanisms of Resistance / edited by Daniel Gioeli.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Gioeli, Daniel.
SpringerLink (Online service)
General Notes:
<p>Resistance to Targeted Therapies As a Result of Mutation(s) in the Target.- The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies.- Cancer Signaling Network Analysis by Quantitative Mass Spectrometry.- </p><p>Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications.- </p><p>Using Phosphoflow to Study Signaling Events of Sub Populations Resistant to Current Therapies -- </p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p><p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance</p><p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p><p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance</p><p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance.<p>.
<p>This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. </p><p><p>Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.</p>
Publisher:
Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781607614784
Subject:
Medicine.
Oncology.
Medicine & Public Health.
Oncology.
Molecular Medicine.
Cancer research.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
<p>Resistance to Targeted Therapies As a Result of Mutation(s) in the Target.- The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies.- Cancer Signaling Network Analysis by Quantitative Mass Spectrometry.- </p><p>Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications.- </p><p>Using Phosphoflow to Study Signaling Events of Sub Populations Resistant to Current Therapies -- </p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p><p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance</p><p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p><p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance</p><p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance.<p>.
Physical Description:
XIV, 201p. 26 illus., 22 illus. in color. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-1-60761-478-4
Publication Date:
2011.
Title:
Targeted Therapies Mechanisms of Resistance / edited by Daniel Gioeli.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Gioeli, Daniel.
SpringerLink (Online service)
General Notes:
<p>Resistance to Targeted Therapies As a Result of Mutation(s) in the Target.- The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies.- Cancer Signaling Network Analysis by Quantitative Mass Spectrometry.- </p><p>Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications.- </p><p>Using Phosphoflow to Study Signaling Events of Sub Populations Resistant to Current Therapies -- </p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p><p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance</p><p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p><p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance</p><p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance.<p>.
<p>This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. </p><p><p>Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.</p>
Publisher:
Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781607614784
Subject:
Medicine.
Oncology.
Medicine & Public Health.
Oncology.
Molecular Medicine.
Cancer research.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
<p>Resistance to Targeted Therapies As a Result of Mutation(s) in the Target.- The Dynamics of the Cell Signaling Network; Implications for Targeted Therapies.- Cancer Signaling Network Analysis by Quantitative Mass Spectrometry.- </p><p>Development and Implementation of Array Technologies for Proteomics: Clinical Implications and Applications.- </p><p>Using Phosphoflow to Study Signaling Events of Sub Populations Resistant to Current Therapies -- </p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p><p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance</p><p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p><p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance</p><p><p>Mathematical and Computational Models in Cancer -- </p><p>Somatic Evolution of Acquired Drug Resistance in Cancer -- </p><p>Interrogating Resistance to Targeted Therapy Using Genetically Engineered Mouse Models of Cancer -- </p>MicroRNA: A Potential Therapy Able to Target Multiple Cancer Pathways -- Rational Combination of Targeted Agents to Overcome Cancer Cell Resistance.<p>.
Physical Description:
XIV, 201p. 26 illus., 22 illus. in color. digital.
Electronic Location:
http://dx.doi.org/10.1007/978-1-60761-478-4
Publication Date:
2011.
Title:
Translational Cardiology Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques / edited by Cam Patterson, Monte S. Willis.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Patterson, Cam. editor.
Willis, Monte S. editor.
SpringerLink (Online service)
General Notes:
Relationship Between Myocardial Ischemia/Reperfusion and Time-of-Day -- Phosphotransfer Reactions in the Failing Heart -- Mitochondria in Cardiac Disease -- PPAR/PGC-1 Regulation of Metabolism in Cardiac Disease -- AMPK and Metabolic Remodeling in Cardiac Disease -- Mechanotransduction in Cardiac Hypertrophy and Ischemia -- Cardiac Plasticity in Health and Disease -- Ubiquitylation‐Dependent Signaling in Heart Disease -- Mechanisms of Cardiac Dysfunction Associated with Cancer Therapeutics -- Molecular Basis of Cardiac Development and Congenital Heart Disease -- Cellular Therapy for the Infarcted Myocardium -- Novel Approaches to Deliver Molecular Therapeutics in Cardiac Disease Using Adeno-Associated Virus Vectors -- Novel Delivery of Molecular Therapeutics to the Heart Using Non-Biologic Constructs (PPMO/Morpholino) in Muscular Dystrophy -- Molecular Imaging of Cardiovascular Disease.
Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.
Publisher:
Humana Press : Imprint: Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781617798917
Subject:
Medicine.
Cardiology.
Pathology.
Medicine & Public Health.
Pathology.
Cardiology.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
Relationship Between Myocardial Ischemia/Reperfusion and Time-of-Day -- Phosphotransfer Reactions in the Failing Heart -- Mitochondria in Cardiac Disease -- PPAR/PGC-1 Regulation of Metabolism in Cardiac Disease -- AMPK and Metabolic Remodeling in Cardiac Disease -- Mechanotransduction in Cardiac Hypertrophy and Ischemia -- Cardiac Plasticity in Health and Disease -- Ubiquitylation‐Dependent Signaling in Heart Disease -- Mechanisms of Cardiac Dysfunction Associated with Cancer Therapeutics -- Molecular Basis of Cardiac Development and Congenital Heart Disease -- Cellular Therapy for the Infarcted Myocardium -- Novel Approaches to Deliver Molecular Therapeutics in Cardiac Disease Using Adeno-Associated Virus Vectors -- Novel Delivery of Molecular Therapeutics to the Heart Using Non-Biologic Constructs (PPMO/Morpholino) in Muscular Dystrophy -- Molecular Imaging of Cardiovascular Disease.
Physical Description:
XV, 543 p. 67 illus., 52 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-61779-891-7
Publication Date:
2012.
Title:
Translational Cardiology Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques / edited by Cam Patterson, Monte S. Willis.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Patterson, Cam. editor.
Willis, Monte S. editor.
SpringerLink (Online service)
General Notes:
Relationship Between Myocardial Ischemia/Reperfusion and Time-of-Day -- Phosphotransfer Reactions in the Failing Heart -- Mitochondria in Cardiac Disease -- PPAR/PGC-1 Regulation of Metabolism in Cardiac Disease -- AMPK and Metabolic Remodeling in Cardiac Disease -- Mechanotransduction in Cardiac Hypertrophy and Ischemia -- Cardiac Plasticity in Health and Disease -- Ubiquitylation‐Dependent Signaling in Heart Disease -- Mechanisms of Cardiac Dysfunction Associated with Cancer Therapeutics -- Molecular Basis of Cardiac Development and Congenital Heart Disease -- Cellular Therapy for the Infarcted Myocardium -- Novel Approaches to Deliver Molecular Therapeutics in Cardiac Disease Using Adeno-Associated Virus Vectors -- Novel Delivery of Molecular Therapeutics to the Heart Using Non-Biologic Constructs (PPMO/Morpholino) in Muscular Dystrophy -- Molecular Imaging of Cardiovascular Disease.
Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.
Publisher:
Humana Press : Imprint: Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781617798917
Subject:
Medicine.
Cardiology.
Pathology.
Medicine & Public Health.
Pathology.
Cardiology.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
Relationship Between Myocardial Ischemia/Reperfusion and Time-of-Day -- Phosphotransfer Reactions in the Failing Heart -- Mitochondria in Cardiac Disease -- PPAR/PGC-1 Regulation of Metabolism in Cardiac Disease -- AMPK and Metabolic Remodeling in Cardiac Disease -- Mechanotransduction in Cardiac Hypertrophy and Ischemia -- Cardiac Plasticity in Health and Disease -- Ubiquitylation‐Dependent Signaling in Heart Disease -- Mechanisms of Cardiac Dysfunction Associated with Cancer Therapeutics -- Molecular Basis of Cardiac Development and Congenital Heart Disease -- Cellular Therapy for the Infarcted Myocardium -- Novel Approaches to Deliver Molecular Therapeutics in Cardiac Disease Using Adeno-Associated Virus Vectors -- Novel Delivery of Molecular Therapeutics to the Heart Using Non-Biologic Constructs (PPMO/Morpholino) in Muscular Dystrophy -- Molecular Imaging of Cardiovascular Disease.
Physical Description:
XV, 543 p. 67 illus., 52 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-61779-891-7
Publication Date:
2012.
Title:
Molecular and Translational Vascular Medicine edited by Jonathon W. Homeister, Monte S. Willis.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Homeister, Jonathon W. editor.
Willis, Monte S. editor.
SpringerLink (Online service)
General Notes:
The Molecular Biology and Genetics of Aneurysms -- The Molecular Biology and Treatment of Systemic Vasculitis in Children -- Recent Insights into the Molecular and Cellular Contributions to Venous Thrombosis -- The Ubiquitin Proteasome System in Endothelial Cell Dysfunction and Vascular Disease -- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis -- Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions -- Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges -- Modulating the proliferative response to treat restenosis after vascular injury -- Cardiovascular Nanomedicine: Challenges and Opportunities -- Endothelial Progenitor Cells in the Treatment of Vascular Disease.
Molecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine. The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis. Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascular disease, endothelial progenitor cells for disease treatment, and the genetic basis of thoracic aortic aneurysms. Lastly, this volume includes sections on the newly emerging field of therapeutic angiogenesis, and the developing technology of nanoparticle-based imaging and therapeutic treatment of the diseased vasculature. All chapters are written by established experts in their fields, including pathologists, cardiovascular surgeons, and internists as well as translational biomedical researchers in a wide range of disciplines. While comprehensive, the material is presented in a manner that simplifies the complex pathophysiologic mechanisms that underlie common vascular diseases. Molecular and Translational Vascular Medicine will be of great value to a broad audience including internists, cardiovascular and vascular surgeons, pathologists, residents and fellows, as well as translational biomedical researchers.
Publisher:
Humana Press : Imprint: Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781617799068
Subject:
Medicine.
Cardiology.
Pathology.
Medicine & Public Health.
Pathology.
Cardiology.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
The Molecular Biology and Genetics of Aneurysms -- The Molecular Biology and Treatment of Systemic Vasculitis in Children -- Recent Insights into the Molecular and Cellular Contributions to Venous Thrombosis -- The Ubiquitin Proteasome System in Endothelial Cell Dysfunction and Vascular Disease -- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis -- Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions -- Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges -- Modulating the proliferative response to treat restenosis after vascular injury -- Cardiovascular Nanomedicine: Challenges and Opportunities -- Endothelial Progenitor Cells in the Treatment of Vascular Disease.
Physical Description:
XIV, 335 p. 42 illus., 36 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-61779-906-8
Publication Date:
2012.
Title:
Molecular and Translational Vascular Medicine edited by Jonathon W. Homeister, Monte S. Willis.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Homeister, Jonathon W. editor.
Willis, Monte S. editor.
SpringerLink (Online service)
General Notes:
The Molecular Biology and Genetics of Aneurysms -- The Molecular Biology and Treatment of Systemic Vasculitis in Children -- Recent Insights into the Molecular and Cellular Contributions to Venous Thrombosis -- The Ubiquitin Proteasome System in Endothelial Cell Dysfunction and Vascular Disease -- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis -- Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions -- Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges -- Modulating the proliferative response to treat restenosis after vascular injury -- Cardiovascular Nanomedicine: Challenges and Opportunities -- Endothelial Progenitor Cells in the Treatment of Vascular Disease.
Molecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine. The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis. Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascular disease, endothelial progenitor cells for disease treatment, and the genetic basis of thoracic aortic aneurysms. Lastly, this volume includes sections on the newly emerging field of therapeutic angiogenesis, and the developing technology of nanoparticle-based imaging and therapeutic treatment of the diseased vasculature. All chapters are written by established experts in their fields, including pathologists, cardiovascular surgeons, and internists as well as translational biomedical researchers in a wide range of disciplines. While comprehensive, the material is presented in a manner that simplifies the complex pathophysiologic mechanisms that underlie common vascular diseases. Molecular and Translational Vascular Medicine will be of great value to a broad audience including internists, cardiovascular and vascular surgeons, pathologists, residents and fellows, as well as translational biomedical researchers.
Publisher:
Humana Press : Imprint: Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781617799068
Subject:
Medicine.
Cardiology.
Pathology.
Medicine & Public Health.
Pathology.
Cardiology.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
The Molecular Biology and Genetics of Aneurysms -- The Molecular Biology and Treatment of Systemic Vasculitis in Children -- Recent Insights into the Molecular and Cellular Contributions to Venous Thrombosis -- The Ubiquitin Proteasome System in Endothelial Cell Dysfunction and Vascular Disease -- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis -- Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions -- Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges -- Modulating the proliferative response to treat restenosis after vascular injury -- Cardiovascular Nanomedicine: Challenges and Opportunities -- Endothelial Progenitor Cells in the Treatment of Vascular Disease.
Physical Description:
XIV, 335 p. 42 illus., 36 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-61779-906-8
Publication Date:
2012.
Title:
Pediatric Neoplasia Advances in Molecular Pathology and Translational Medicine / edited by Alexander Craig Mackinnon Jr.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Mackinnon Jr, Alexander Craig. editor.
SpringerLink (Online service)
General Notes:
1. Towards Personalized Medicine in Pediatric Cancer: Genome-Wide Strategies to Investigate Cancer Risk and Response to Therapy -- 2. Acute Leukemia -- 3. Molecular Techniques Used in Evaluation of Pediatric Acute Leukemia -- 4. Myelodysplasia and Myeloid Proliferations -- 5. Childhood Lymphoma -- 6. Children are Not Small Adults: Importance of Molecular Analysis for Diagnosis, Prognosis, and Treatment of Pediatric CNS Tumors -- 7. Pediatric Bone Tumors -- 8. Soft Tissue “Small Round Blue Cell Tumors” of Childhood -- 9. Fibroblastic and Myofibroblastic Pediatric Soft Tissue Tumors -- 10. Molecular Analysis in Pediatric Renal Tumors -- 11. Hepatoblastoma: New Insights into the Biology of Embryonal Tumors of the Liver.
Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts in their field with subspecialty training and extensive clinical experience. Each chapter describes a variable number of tumors and includes an overview of the classification system and clinicopathological characteristics of each tumor. This is followed by a discussion of the molecular pathology relevant to a specific tumor, including specific molecular markers of the tumors, methods used for diagnosis or clinical management, clinical significance of the markers, and if appropriate, a description or discussion of current activities in translational research or issues that need to be addressed in the future. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine will be of great value to pathologists, oncologists, hematologists, internal medicine and pediatric specialists, as well as pharmaceutical professionals and translational and clinical researchers.
Publisher:
Humana Press : Imprint: Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781627031165
Subject:
Medicine.
Oncology.
Pathology.
Medicine & Public Health.
Pathology.
Oncology.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
1. Towards Personalized Medicine in Pediatric Cancer: Genome-Wide Strategies to Investigate Cancer Risk and Response to Therapy -- 2. Acute Leukemia -- 3. Molecular Techniques Used in Evaluation of Pediatric Acute Leukemia -- 4. Myelodysplasia and Myeloid Proliferations -- 5. Childhood Lymphoma -- 6. Children are Not Small Adults: Importance of Molecular Analysis for Diagnosis, Prognosis, and Treatment of Pediatric CNS Tumors -- 7. Pediatric Bone Tumors -- 8. Soft Tissue “Small Round Blue Cell Tumors” of Childhood -- 9. Fibroblastic and Myofibroblastic Pediatric Soft Tissue Tumors -- 10. Molecular Analysis in Pediatric Renal Tumors -- 11. Hepatoblastoma: New Insights into the Biology of Embryonal Tumors of the Liver.
Physical Description:
IX, 267 p. 76 illus., 73 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-62703-116-5
Publication Date:
2012.
Title:
Pediatric Neoplasia Advances in Molecular Pathology and Translational Medicine / edited by Alexander Craig Mackinnon Jr.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Mackinnon Jr, Alexander Craig. editor.
SpringerLink (Online service)
General Notes:
1. Towards Personalized Medicine in Pediatric Cancer: Genome-Wide Strategies to Investigate Cancer Risk and Response to Therapy -- 2. Acute Leukemia -- 3. Molecular Techniques Used in Evaluation of Pediatric Acute Leukemia -- 4. Myelodysplasia and Myeloid Proliferations -- 5. Childhood Lymphoma -- 6. Children are Not Small Adults: Importance of Molecular Analysis for Diagnosis, Prognosis, and Treatment of Pediatric CNS Tumors -- 7. Pediatric Bone Tumors -- 8. Soft Tissue “Small Round Blue Cell Tumors” of Childhood -- 9. Fibroblastic and Myofibroblastic Pediatric Soft Tissue Tumors -- 10. Molecular Analysis in Pediatric Renal Tumors -- 11. Hepatoblastoma: New Insights into the Biology of Embryonal Tumors of the Liver.
Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts in their field with subspecialty training and extensive clinical experience. Each chapter describes a variable number of tumors and includes an overview of the classification system and clinicopathological characteristics of each tumor. This is followed by a discussion of the molecular pathology relevant to a specific tumor, including specific molecular markers of the tumors, methods used for diagnosis or clinical management, clinical significance of the markers, and if appropriate, a description or discussion of current activities in translational research or issues that need to be addressed in the future. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine will be of great value to pathologists, oncologists, hematologists, internal medicine and pediatric specialists, as well as pharmaceutical professionals and translational and clinical researchers.
Publisher:
Humana Press : Imprint: Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781627031165
Subject:
Medicine.
Oncology.
Pathology.
Medicine & Public Health.
Pathology.
Oncology.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
1. Towards Personalized Medicine in Pediatric Cancer: Genome-Wide Strategies to Investigate Cancer Risk and Response to Therapy -- 2. Acute Leukemia -- 3. Molecular Techniques Used in Evaluation of Pediatric Acute Leukemia -- 4. Myelodysplasia and Myeloid Proliferations -- 5. Childhood Lymphoma -- 6. Children are Not Small Adults: Importance of Molecular Analysis for Diagnosis, Prognosis, and Treatment of Pediatric CNS Tumors -- 7. Pediatric Bone Tumors -- 8. Soft Tissue “Small Round Blue Cell Tumors” of Childhood -- 9. Fibroblastic and Myofibroblastic Pediatric Soft Tissue Tumors -- 10. Molecular Analysis in Pediatric Renal Tumors -- 11. Hepatoblastoma: New Insights into the Biology of Embryonal Tumors of the Liver.
Physical Description:
IX, 267 p. 76 illus., 73 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-62703-116-5
Publication Date:
2012.
Title:
Molecular Genetics and Personalized Medicine edited by D. Hunter Best, Jeffrey J. Swensen.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Best, D. Hunter. editor.
Swensen, Jeffrey J. editor.
SpringerLink (Online service)
General Notes:
Molecular Genetic Testing in the Genomic Era -- Array Comparative Genomic Hybridization in Cytogenetics and Molecular Genetics -- Pharmacogenomics: Tailoring Treatment Based on Genotype -- Somatic Alterations and Targeted Therapy -- Genome Wide Association Studies in Disease Risk Calculation: The Role of Bioinformatics in Patient Care -- Presymptomatic Genetic Testing: Shifting the Emphasis from Reaction to Prevention -- Prenatal Testing: Screening, Diagnosis and Preimplantation Genetic Diagnosis Eugene Pergament -- Newborn Screening for Metabolic Disorders -- The Role of Genetic Counseling in Everyday Medical Practice -- Direct-to-Consumer Genetic Testing.
Genetic testing has become commonplace, and clinicians are frequently able to use knowledge of an individual’s specific genetic differences to guide their course of action. Molecular Genetics and Personalized Medicine highlights developments that have been made in the field of molecular genetics and how they have been applied clinically. It will serve as a useful reference for physicians hoping to better understand the role of molecular medicine in clinical practice. In addition, it should also prove to be an invaluable resource for the basic scientist that wants to better understand how advances in the laboratory are being moved from the bench to the bedside. All chapters are written by experts in their fields and include the most up to date medical information. The authors simplify complex genetic concepts and focus on practical patient related issues. The book will be of great value to pathologists, hematologists/oncologists, clinical geneticists, high-risk obstetricians, general practitioners, and physicians in all other medical specialties who utilize genetic testing to direct therapy.
Publisher:
Springer New York,
Publication Place:
New York, NY :
ISBN:
9781617795305
Subject:
Medicine.
Oncology.
Pathology.
Medicine & Public Health.
Pathology.
Oncology.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
Molecular Genetic Testing in the Genomic Era -- Array Comparative Genomic Hybridization in Cytogenetics and Molecular Genetics -- Pharmacogenomics: Tailoring Treatment Based on Genotype -- Somatic Alterations and Targeted Therapy -- Genome Wide Association Studies in Disease Risk Calculation: The Role of Bioinformatics in Patient Care -- Presymptomatic Genetic Testing: Shifting the Emphasis from Reaction to Prevention -- Prenatal Testing: Screening, Diagnosis and Preimplantation Genetic Diagnosis Eugene Pergament -- Newborn Screening for Metabolic Disorders -- The Role of Genetic Counseling in Everyday Medical Practice -- Direct-to-Consumer Genetic Testing.
Physical Description:
X, 246 p. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-61779-530-5
Publication Date:
2012.
Title:
Molecular Genetics and Personalized Medicine edited by D. Hunter Best, Jeffrey J. Swensen.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Best, D. Hunter. editor.
Swensen, Jeffrey J. editor.
SpringerLink (Online service)
General Notes:
Molecular Genetic Testing in the Genomic Era -- Array Comparative Genomic Hybridization in Cytogenetics and Molecular Genetics -- Pharmacogenomics: Tailoring Treatment Based on Genotype -- Somatic Alterations and Targeted Therapy -- Genome Wide Association Studies in Disease Risk Calculation: The Role of Bioinformatics in Patient Care -- Presymptomatic Genetic Testing: Shifting the Emphasis from Reaction to Prevention -- Prenatal Testing: Screening, Diagnosis and Preimplantation Genetic Diagnosis Eugene Pergament -- Newborn Screening for Metabolic Disorders -- The Role of Genetic Counseling in Everyday Medical Practice -- Direct-to-Consumer Genetic Testing.
Genetic testing has become commonplace, and clinicians are frequently able to use knowledge of an individual’s specific genetic differences to guide their course of action. Molecular Genetics and Personalized Medicine highlights developments that have been made in the field of molecular genetics and how they have been applied clinically. It will serve as a useful reference for physicians hoping to better understand the role of molecular medicine in clinical practice. In addition, it should also prove to be an invaluable resource for the basic scientist that wants to better understand how advances in the laboratory are being moved from the bench to the bedside. All chapters are written by experts in their fields and include the most up to date medical information. The authors simplify complex genetic concepts and focus on practical patient related issues. The book will be of great value to pathologists, hematologists/oncologists, clinical geneticists, high-risk obstetricians, general practitioners, and physicians in all other medical specialties who utilize genetic testing to direct therapy.
Publisher:
Springer New York,
Publication Place:
New York, NY :
ISBN:
9781617795305
Subject:
Medicine.
Oncology.
Pathology.
Medicine & Public Health.
Pathology.
Oncology.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
Molecular Genetic Testing in the Genomic Era -- Array Comparative Genomic Hybridization in Cytogenetics and Molecular Genetics -- Pharmacogenomics: Tailoring Treatment Based on Genotype -- Somatic Alterations and Targeted Therapy -- Genome Wide Association Studies in Disease Risk Calculation: The Role of Bioinformatics in Patient Care -- Presymptomatic Genetic Testing: Shifting the Emphasis from Reaction to Prevention -- Prenatal Testing: Screening, Diagnosis and Preimplantation Genetic Diagnosis Eugene Pergament -- Newborn Screening for Metabolic Disorders -- The Role of Genetic Counseling in Everyday Medical Practice -- Direct-to-Consumer Genetic Testing.
Physical Description:
X, 246 p. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-61779-530-5
Publication Date:
2012.
Title:
Molecular Diagnostics 12 Tests That Changed Everything / edited by W. Edward Highsmith, Jr.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Highsmith, Jr., W. Edward. editor.
SpringerLink (Online service)
General Notes:
Clinical FISH Testing for the Diagnosis of Solid Tumors -- Epidermal Growth Factor Receptor Testing in Lung Adenocarcinoma -- The Human Epidermal Growth Factor Receptor 2 (HER2) -- Tamoxifen and Irinotecan Pharmacogenomics -- Hepatitis C Virus Testing -- Laboratory Testing for HIV Infection: Advances after 27 years -- Detection of Herpes Simplex Virus in Cerebrospinal Fluid using Real-time PCR -- Toward a Safer Blood Supply: The Impact of Molecular Testing -- Chromosomal Microarrays -- BRCA1 and BRCA2 Testing in Inherited Breast Cancer -- Cystic Fibrosis: Carrier Testing, Newborn Screening, and Diagnostic Testing -- Newborn Screening by Tandem Mass Spectrometry and Molecular Confirmation -- Next Generation Clinical Diagnostics: The Sequence of Events.
Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test has changed the way medicine is practiced with respect to the disease or condition in question. Authored by renowned experts in the field, Molecular Diagnostics: 12 Tests That Changed Everything is a valuable resource for pathologists, pathology residents, laboratory directors, development personnel, lab medicine fellows and those working in the broad area of oncology, infectious disease and genetics.
Publisher:
Springer New York : Imprint: Humana Press,
Publication Place:
New York, NY :
ISBN:
9781461481270
Subject:
Medicine.
Infectious diseases.
Oncology.
Pathology.
Medicine & Public Health.
Pathology.
Oncology.
Infectious diseases.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
Clinical FISH Testing for the Diagnosis of Solid Tumors -- Epidermal Growth Factor Receptor Testing in Lung Adenocarcinoma -- The Human Epidermal Growth Factor Receptor 2 (HER2) -- Tamoxifen and Irinotecan Pharmacogenomics -- Hepatitis C Virus Testing -- Laboratory Testing for HIV Infection: Advances after 27 years -- Detection of Herpes Simplex Virus in Cerebrospinal Fluid using Real-time PCR -- Toward a Safer Blood Supply: The Impact of Molecular Testing -- Chromosomal Microarrays -- BRCA1 and BRCA2 Testing in Inherited Breast Cancer -- Cystic Fibrosis: Carrier Testing, Newborn Screening, and Diagnostic Testing -- Newborn Screening by Tandem Mass Spectrometry and Molecular Confirmation -- Next Generation Clinical Diagnostics: The Sequence of Events.
Physical Description:
XIII, 257 p. 47 illus., 41 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4614-8127-0
Publication Date:
2014.
Title:
Molecular Diagnostics 12 Tests That Changed Everything / edited by W. Edward Highsmith, Jr.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Highsmith, Jr., W. Edward. editor.
SpringerLink (Online service)
General Notes:
Clinical FISH Testing for the Diagnosis of Solid Tumors -- Epidermal Growth Factor Receptor Testing in Lung Adenocarcinoma -- The Human Epidermal Growth Factor Receptor 2 (HER2) -- Tamoxifen and Irinotecan Pharmacogenomics -- Hepatitis C Virus Testing -- Laboratory Testing for HIV Infection: Advances after 27 years -- Detection of Herpes Simplex Virus in Cerebrospinal Fluid using Real-time PCR -- Toward a Safer Blood Supply: The Impact of Molecular Testing -- Chromosomal Microarrays -- BRCA1 and BRCA2 Testing in Inherited Breast Cancer -- Cystic Fibrosis: Carrier Testing, Newborn Screening, and Diagnostic Testing -- Newborn Screening by Tandem Mass Spectrometry and Molecular Confirmation -- Next Generation Clinical Diagnostics: The Sequence of Events.
Molecular Diagnostics: 12 Tests That Changed Everything focuses on specific laboratory tests and emphasizes how the availability of these tests has altered how clinicians treat their patients. Presented as a standard outline, each chapter focuses on a specific molecular test and provides background on the test and its clinical applications. Continuing with some discussion on how the test is done, interpreted, and used clinically, each chapter then concludes with a discussion of how that test has changed the way medicine is practiced with respect to the disease or condition in question. Authored by renowned experts in the field, Molecular Diagnostics: 12 Tests That Changed Everything is a valuable resource for pathologists, pathology residents, laboratory directors, development personnel, lab medicine fellows and those working in the broad area of oncology, infectious disease and genetics.
Publisher:
Springer New York : Imprint: Humana Press,
Publication Place:
New York, NY :
ISBN:
9781461481270
Subject:
Medicine.
Infectious diseases.
Oncology.
Pathology.
Medicine & Public Health.
Pathology.
Oncology.
Infectious diseases.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
Clinical FISH Testing for the Diagnosis of Solid Tumors -- Epidermal Growth Factor Receptor Testing in Lung Adenocarcinoma -- The Human Epidermal Growth Factor Receptor 2 (HER2) -- Tamoxifen and Irinotecan Pharmacogenomics -- Hepatitis C Virus Testing -- Laboratory Testing for HIV Infection: Advances after 27 years -- Detection of Herpes Simplex Virus in Cerebrospinal Fluid using Real-time PCR -- Toward a Safer Blood Supply: The Impact of Molecular Testing -- Chromosomal Microarrays -- BRCA1 and BRCA2 Testing in Inherited Breast Cancer -- Cystic Fibrosis: Carrier Testing, Newborn Screening, and Diagnostic Testing -- Newborn Screening by Tandem Mass Spectrometry and Molecular Confirmation -- Next Generation Clinical Diagnostics: The Sequence of Events.
Physical Description:
XIII, 257 p. 47 illus., 41 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4614-8127-0
Publication Date:
2014.
Title:
Effects of Exercise on Hypertension From Cells to Physiological Systems / edited by Linda S. Pescatello.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
Pescatello, Linda S. editor.
SpringerLink (Online service)
General Notes:
Effects of aerobic exercise on hypertension -- Overview of effects of resistance exercise on hypertension -- Cardiorespiratory Fitness and Mortality in Pre-Hypertensive and Hypertensive Individuals -- Exaggerated blood pressure response to exercise and its clinical significance -- Effects of exercise on the autonomic nervous system -- Effects of Exercise on Autonomic Function -- Cardiac output and contractility -- Effects of exercise on metabolic syndrome -- Effects of exercise on pro-oxidant and anti-oxidant systems -- Aerobic exercise and vascular function (endothelial-dependent and –independent function) -- Resistance exercise and vascular function (endothelial-dependent and –independent function) -- Effects of exercise on arterial stiffness -- Vasoactive substances -- Effects of aerobic exercise training on animal models of hypertension -- Effects of in vitro laminar shear stress as an exercise mimetic on endothelial cell health.
This text explores the state-of-the-art effects of exercise on blood pressure among adults with hypertension in addition to many of the possible mechanisms underlying essential hypertension in humans. The book contains chapters by distinguished experts on the effects of exercise on physiological systems known to be involved in hypertension development and maintenance as well as less well known aspects of hypertension such as exercise effects on the 24-hour ambulatory blood pressure profile, and inflammation and oxidative stress as they relate to hypertension. An emerging area, the effects of resistance exercise training on blood pressure is also covered. A unique aspect of the book is that it covers the effects of exercise mimetics on vascular cell adaptations in order to begin to elucidate some of the cellular mechanisms that may underlie blood pressure reductions with exercise training. The text also contains a chapter on the interactive effects of genes and exercise on blood pressure. Effects of Exercise on Hypertension: From Cells to Physiological Systems will be of great value to professional individuals in cardiovascular medicine, the cardiovascular sciences, allied health care professionals, and medical and graduate students in the cardiovascular sciences and medicine.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319170763
Subject:
Medicine.
Molecular biology.
Cardiology.
Medicine & Public Health.
Cardiology.
Molecular Medicine.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Contents:
Effects of aerobic exercise on hypertension -- Overview of effects of resistance exercise on hypertension -- Cardiorespiratory Fitness and Mortality in Pre-Hypertensive and Hypertensive Individuals -- Exaggerated blood pressure response to exercise and its clinical significance -- Effects of exercise on the autonomic nervous system -- Effects of Exercise on Autonomic Function -- Cardiac output and contractility -- Effects of exercise on metabolic syndrome -- Effects of exercise on pro-oxidant and anti-oxidant systems -- Aerobic exercise and vascular function (endothelial-dependent and –independent function) -- Resistance exercise and vascular function (endothelial-dependent and –independent function) -- Effects of exercise on arterial stiffness -- Vasoactive substances -- Effects of aerobic exercise training on animal models of hypertension -- Effects of in vitro laminar shear stress as an exercise mimetic on endothelial cell health.
Physical Description:
XVII, 334 p. 27 illus., 13 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-17076-3
Publication Date:
2015.
Title:
Effects of Exercise on Hypertension From Cells to Physiological Systems / edited by Linda S. Pescatello.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
Pescatello, Linda S. editor.
SpringerLink (Online service)
General Notes:
Effects of aerobic exercise on hypertension -- Overview of effects of resistance exercise on hypertension -- Cardiorespiratory Fitness and Mortality in Pre-Hypertensive and Hypertensive Individuals -- Exaggerated blood pressure response to exercise and its clinical significance -- Effects of exercise on the autonomic nervous system -- Effects of Exercise on Autonomic Function -- Cardiac output and contractility -- Effects of exercise on metabolic syndrome -- Effects of exercise on pro-oxidant and anti-oxidant systems -- Aerobic exercise and vascular function (endothelial-dependent and –independent function) -- Resistance exercise and vascular function (endothelial-dependent and –independent function) -- Effects of exercise on arterial stiffness -- Vasoactive substances -- Effects of aerobic exercise training on animal models of hypertension -- Effects of in vitro laminar shear stress as an exercise mimetic on endothelial cell health.
This text explores the state-of-the-art effects of exercise on blood pressure among adults with hypertension in addition to many of the possible mechanisms underlying essential hypertension in humans. The book contains chapters by distinguished experts on the effects of exercise on physiological systems known to be involved in hypertension development and maintenance as well as less well known aspects of hypertension such as exercise effects on the 24-hour ambulatory blood pressure profile, and inflammation and oxidative stress as they relate to hypertension. An emerging area, the effects of resistance exercise training on blood pressure is also covered. A unique aspect of the book is that it covers the effects of exercise mimetics on vascular cell adaptations in order to begin to elucidate some of the cellular mechanisms that may underlie blood pressure reductions with exercise training. The text also contains a chapter on the interactive effects of genes and exercise on blood pressure. Effects of Exercise on Hypertension: From Cells to Physiological Systems will be of great value to professional individuals in cardiovascular medicine, the cardiovascular sciences, allied health care professionals, and medical and graduate students in the cardiovascular sciences and medicine.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319170763
Subject:
Medicine.
Molecular biology.
Cardiology.
Medicine & Public Health.
Cardiology.
Molecular Medicine.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Contents:
Effects of aerobic exercise on hypertension -- Overview of effects of resistance exercise on hypertension -- Cardiorespiratory Fitness and Mortality in Pre-Hypertensive and Hypertensive Individuals -- Exaggerated blood pressure response to exercise and its clinical significance -- Effects of exercise on the autonomic nervous system -- Effects of Exercise on Autonomic Function -- Cardiac output and contractility -- Effects of exercise on metabolic syndrome -- Effects of exercise on pro-oxidant and anti-oxidant systems -- Aerobic exercise and vascular function (endothelial-dependent and –independent function) -- Resistance exercise and vascular function (endothelial-dependent and –independent function) -- Effects of exercise on arterial stiffness -- Vasoactive substances -- Effects of aerobic exercise training on animal models of hypertension -- Effects of in vitro laminar shear stress as an exercise mimetic on endothelial cell health.
Physical Description:
XVII, 334 p. 27 illus., 13 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-17076-3
Publication Date:
2015.
Title:
Vascular Tumors and Developmental Malformations Pathogenic Mechanisms and Molecular Diagnosis / edited by Paula E. North, Tara Sander.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
North, Paula E. editor.
Sander, Tara. editor.
SpringerLink (Online service)
General Notes:
Histopathology and Pathogenesis of Vascular Tumors and Malformations -- Vascular Overgrowth -- Vasculogenesis and Angiogenesis -- The Genetic Basis and Molecular Diagnosis of Vascular Tumors and Developmental Malformations -- Clinical Management and Treatment of Vascular Tumors.
This book comprehensively covers the classification, histopathology, pathogenesis, and molecular diagnosis of vascular tumors and malformations, correlating these with current approaches to clinical management. It offers a new multidisciplinary resource for clinicians, pathologists, molecular diagnosticians, and scientists in the field of vascular medicine and biology, fostering cross-cutting collaboration in clinical practice and research. Fundamental background information on vascular tumors and malformation is provided, while also including the most current information available on pathogenic mechanisms underlying this heterogenous group of disorders and the implications for molecular diagnosis and therapeutic intervention. Written by experts in the field, Vascular Tumors and Developmental Malformations: Pathogenic Mechanisms and Molecular Diagnosis provides the medical and scientific community with an essential, practical resource to guide accurate diagnosis, well-targeted therapies, and informed investigation of specific clinicopathological entities within the spectrum of vascular anomalies.
Publisher:
Springer New York : Imprint: Springer,
Publication Place:
New York, NY :
ISBN:
9781493932405
Subject:
Medicine.
Molecular biology.
Pathology.
Medicine & Public Health.
Pathology.
Molecular Medicine.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Edition:
1st ed. 2016.
Contents:
Histopathology and Pathogenesis of Vascular Tumors and Malformations -- Vascular Overgrowth -- Vasculogenesis and Angiogenesis -- The Genetic Basis and Molecular Diagnosis of Vascular Tumors and Developmental Malformations -- Clinical Management and Treatment of Vascular Tumors.
Physical Description:
X, 149 p. 49 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4939-3240-5
Publication Date:
2016.
Title:
Vascular Tumors and Developmental Malformations Pathogenic Mechanisms and Molecular Diagnosis / edited by Paula E. North, Tara Sander.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
North, Paula E. editor.
Sander, Tara. editor.
SpringerLink (Online service)
General Notes:
Histopathology and Pathogenesis of Vascular Tumors and Malformations -- Vascular Overgrowth -- Vasculogenesis and Angiogenesis -- The Genetic Basis and Molecular Diagnosis of Vascular Tumors and Developmental Malformations -- Clinical Management and Treatment of Vascular Tumors.
This book comprehensively covers the classification, histopathology, pathogenesis, and molecular diagnosis of vascular tumors and malformations, correlating these with current approaches to clinical management. It offers a new multidisciplinary resource for clinicians, pathologists, molecular diagnosticians, and scientists in the field of vascular medicine and biology, fostering cross-cutting collaboration in clinical practice and research. Fundamental background information on vascular tumors and malformation is provided, while also including the most current information available on pathogenic mechanisms underlying this heterogenous group of disorders and the implications for molecular diagnosis and therapeutic intervention. Written by experts in the field, Vascular Tumors and Developmental Malformations: Pathogenic Mechanisms and Molecular Diagnosis provides the medical and scientific community with an essential, practical resource to guide accurate diagnosis, well-targeted therapies, and informed investigation of specific clinicopathological entities within the spectrum of vascular anomalies.
Publisher:
Springer New York : Imprint: Springer,
Publication Place:
New York, NY :
ISBN:
9781493932405
Subject:
Medicine.
Molecular biology.
Pathology.
Medicine & Public Health.
Pathology.
Molecular Medicine.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Edition:
1st ed. 2016.
Contents:
Histopathology and Pathogenesis of Vascular Tumors and Malformations -- Vascular Overgrowth -- Vasculogenesis and Angiogenesis -- The Genetic Basis and Molecular Diagnosis of Vascular Tumors and Developmental Malformations -- Clinical Management and Treatment of Vascular Tumors.
Physical Description:
X, 149 p. 49 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-4939-3240-5
Publication Date:
2016.
Title:
Hepatitis B Virus in Human Diseases edited by Yun-Fan Liaw, Fabien Zoulim.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
Liaw, Yun-Fan. editor.
Zoulim, Fabien. editor.
SpringerLink (Online service)
General Notes:
HBV Virology and Replication -- Experimental Models: Cell Culture and Animal Models -- Hepatitis B Virus Genotypes -- HBV Immunopathogenesis -- Carcinogenesis -- Hepatitis B Virus: Persistence and Clearance -- HDV Virology and Replication -- Translational Medicine in HBV—What Can We Learn from Clinical Samples? -- Global Epidemiology of HBV Infection -- Clinical Virology: Diagnosis and Virologic Monitoring -- Natural History of Hepatitis B Virus Infection -- Natural History of HBV Infection in the Community -- Occult HBV Infection -- The Basis for Antiviral Therapy: Drug Targets, Cross-Resistance and Novel Small Molecule Inhibitors -- IFN-Based Therapy and Management of Patients -- Nucleoside Analogue-Based Therapy and Management of Patients (Including HIV Co-infections, HBV and Pregnancy) -- Organ Transplantation in HBV Infected Patients -- Reactivation of Hepatitis B Virus Due to Cancer Chemotherapy and Other Immunosuppressive Drug Therapy -- Immunoprophylaxis of Hepatitis B Virus Infection and Its Sequelae -- Towards HBV Eradication.
This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for students, clinicians, and researchers with an interest in hepatitis B. The book reviews new data about basic and translational science including the viral life cycle, the immunopathogenesis of virus induced chronic hepatitis, the mechanism of virus induced liver cancer, and their potential applications for the clinical management of patients. The clinical aspects of this chronic viral infection are reviewed in detail with important chapters on the global epidemiology, the natural history of the disease, co-infections with its satellite virus HDV or HIV, and management of special patient populations. A major emphasis is made on the management of antiviral therapy and the recent international guidelines for the treatment of hepatitis B. Finally, the book reviews the current state of the art regarding immunoprophylaxis to prevent the spread of the virus and its major clinical consequences. The new advances and perspectives in the development of improved antiviral treatments are also discussed. Hepatitis B Virus in Human Diseases will serve as a very useful resource for students, physicians and researchers dealing with, and interested in, this challenging chronic viral infection. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information. .
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319223308
Subject:
Medicine.
Gastroenterology.
Hepatology.
Infectious diseases.
Medicine & Public Health.
Hepatology.
Gastroenterology.
Infectious diseases.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Edition:
1st ed. 2016.
Contents:
HBV Virology and Replication -- Experimental Models: Cell Culture and Animal Models -- Hepatitis B Virus Genotypes -- HBV Immunopathogenesis -- Carcinogenesis -- Hepatitis B Virus: Persistence and Clearance -- HDV Virology and Replication -- Translational Medicine in HBV—What Can We Learn from Clinical Samples? -- Global Epidemiology of HBV Infection -- Clinical Virology: Diagnosis and Virologic Monitoring -- Natural History of Hepatitis B Virus Infection -- Natural History of HBV Infection in the Community -- Occult HBV Infection -- The Basis for Antiviral Therapy: Drug Targets, Cross-Resistance and Novel Small Molecule Inhibitors -- IFN-Based Therapy and Management of Patients -- Nucleoside Analogue-Based Therapy and Management of Patients (Including HIV Co-infections, HBV and Pregnancy) -- Organ Transplantation in HBV Infected Patients -- Reactivation of Hepatitis B Virus Due to Cancer Chemotherapy and Other Immunosuppressive Drug Therapy -- Immunoprophylaxis of Hepatitis B Virus Infection and Its Sequelae -- Towards HBV Eradication.
Physical Description:
XVI, 468 p. 58 illus., 44 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-22330-8
Publication Date:
2016.
Title:
Hepatitis B Virus in Human Diseases edited by Yun-Fan Liaw, Fabien Zoulim.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
Liaw, Yun-Fan. editor.
Zoulim, Fabien. editor.
SpringerLink (Online service)
General Notes:
HBV Virology and Replication -- Experimental Models: Cell Culture and Animal Models -- Hepatitis B Virus Genotypes -- HBV Immunopathogenesis -- Carcinogenesis -- Hepatitis B Virus: Persistence and Clearance -- HDV Virology and Replication -- Translational Medicine in HBV—What Can We Learn from Clinical Samples? -- Global Epidemiology of HBV Infection -- Clinical Virology: Diagnosis and Virologic Monitoring -- Natural History of Hepatitis B Virus Infection -- Natural History of HBV Infection in the Community -- Occult HBV Infection -- The Basis for Antiviral Therapy: Drug Targets, Cross-Resistance and Novel Small Molecule Inhibitors -- IFN-Based Therapy and Management of Patients -- Nucleoside Analogue-Based Therapy and Management of Patients (Including HIV Co-infections, HBV and Pregnancy) -- Organ Transplantation in HBV Infected Patients -- Reactivation of Hepatitis B Virus Due to Cancer Chemotherapy and Other Immunosuppressive Drug Therapy -- Immunoprophylaxis of Hepatitis B Virus Infection and Its Sequelae -- Towards HBV Eradication.
This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for students, clinicians, and researchers with an interest in hepatitis B. The book reviews new data about basic and translational science including the viral life cycle, the immunopathogenesis of virus induced chronic hepatitis, the mechanism of virus induced liver cancer, and their potential applications for the clinical management of patients. The clinical aspects of this chronic viral infection are reviewed in detail with important chapters on the global epidemiology, the natural history of the disease, co-infections with its satellite virus HDV or HIV, and management of special patient populations. A major emphasis is made on the management of antiviral therapy and the recent international guidelines for the treatment of hepatitis B. Finally, the book reviews the current state of the art regarding immunoprophylaxis to prevent the spread of the virus and its major clinical consequences. The new advances and perspectives in the development of improved antiviral treatments are also discussed. Hepatitis B Virus in Human Diseases will serve as a very useful resource for students, physicians and researchers dealing with, and interested in, this challenging chronic viral infection. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information. .
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319223308
Subject:
Medicine.
Gastroenterology.
Hepatology.
Infectious diseases.
Medicine & Public Health.
Hepatology.
Gastroenterology.
Infectious diseases.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Edition:
1st ed. 2016.
Contents:
HBV Virology and Replication -- Experimental Models: Cell Culture and Animal Models -- Hepatitis B Virus Genotypes -- HBV Immunopathogenesis -- Carcinogenesis -- Hepatitis B Virus: Persistence and Clearance -- HDV Virology and Replication -- Translational Medicine in HBV—What Can We Learn from Clinical Samples? -- Global Epidemiology of HBV Infection -- Clinical Virology: Diagnosis and Virologic Monitoring -- Natural History of Hepatitis B Virus Infection -- Natural History of HBV Infection in the Community -- Occult HBV Infection -- The Basis for Antiviral Therapy: Drug Targets, Cross-Resistance and Novel Small Molecule Inhibitors -- IFN-Based Therapy and Management of Patients -- Nucleoside Analogue-Based Therapy and Management of Patients (Including HIV Co-infections, HBV and Pregnancy) -- Organ Transplantation in HBV Infected Patients -- Reactivation of Hepatitis B Virus Due to Cancer Chemotherapy and Other Immunosuppressive Drug Therapy -- Immunoprophylaxis of Hepatitis B Virus Infection and Its Sequelae -- Towards HBV Eradication.
Physical Description:
XVI, 468 p. 58 illus., 44 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-22330-8
Publication Date:
2016.
Title:
Patient-Derived Mouse Models of Cancer Patient-Derived Orthotopic Xenografts (PDOX) / edited by Robert M. Hoffman.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
Hoffman, Robert M. editor.
SpringerLink (Online service)
General Notes:
In memorium: Jorgen Rygaard (1934-2016) Father of patient derived mouse models of cancer and modern cancer research -- The revival of patient-derived mouse models of cancer: way back to the future -- Patient-derived xenograft models for human cancer, The Freiburg experience -- From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype -- The Effects of the Organ Microenvironment on Metastatic-Cell Gene Signatures -- Techniques for surgical orthotopic implantation of human tumors to immunodeficient mice -- The first patient-derived orthotopic xenograft (PDOX) mouse models of cancer: Cancer of the colon, pancreas, lung, breast, ovary, and mesothelioma -- Patient-derived xenograft models of prostate cancer -- Patient-Derived Mouse Models of Sarcoma -- Cervical cancer patient-derived orthotopic xenograft (PDOX) models -- The use of pediatric patient-derived xenografts for identifying novel agents and combinations -- Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics -- Use of patient-derived orthotopic xenografts (PDOX) to evaluate transformative cancer therapeutics -- Fluorescent protein-expressing transgenic nude mice as hosts for patient tumors -- Fluorescence imaging of tumors in human patient-derived orthotopic xenograft (PDOX) mouse models: The iPDOX model -- The use of patient-derived orthotopic xenograft (PDOX) models to develop curative fluorescence-guided surgery of cancer.-Molecular characteristics of patient-derived tumor xenografts: genomic similarity to patient tumors and relevance for biomarker discovery -- Complementarity of patient-derived orthotopic xenografts (PDOX) models and molecular profiling for optimal therapy -- 3D Cell Culture Models -- Why patient derived mouse models need to be orthotopic -- Foreward: The future of patient-derived models of cancer. .
This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319574240
Subject:
Medicine.
Cancer research.
Oncology.
Medicine & Public Health.
Oncology.
Cancer research.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Contents:
In memorium: Jorgen Rygaard (1934-2016) Father of patient derived mouse models of cancer and modern cancer research -- The revival of patient-derived mouse models of cancer: way back to the future -- Patient-derived xenograft models for human cancer, The Freiburg experience -- From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype -- The Effects of the Organ Microenvironment on Metastatic-Cell Gene Signatures -- Techniques for surgical orthotopic implantation of human tumors to immunodeficient mice -- The first patient-derived orthotopic xenograft (PDOX) mouse models of cancer: Cancer of the colon, pancreas, lung, breast, ovary, and mesothelioma -- Patient-derived xenograft models of prostate cancer -- Patient-Derived Mouse Models of Sarcoma -- Cervical cancer patient-derived orthotopic xenograft (PDOX) models -- The use of pediatric patient-derived xenografts for identifying novel agents and combinations -- Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics -- Use of patient-derived orthotopic xenografts (PDOX) to evaluate transformative cancer therapeutics -- Fluorescent protein-expressing transgenic nude mice as hosts for patient tumors -- Fluorescence imaging of tumors in human patient-derived orthotopic xenograft (PDOX) mouse models: The iPDOX model -- The use of patient-derived orthotopic xenograft (PDOX) models to develop curative fluorescence-guided surgery of cancer.-Molecular characteristics of patient-derived tumor xenografts: genomic similarity to patient tumors and relevance for biomarker discovery -- Complementarity of patient-derived orthotopic xenografts (PDOX) models and molecular profiling for optimal therapy -- 3D Cell Culture Models -- Why patient derived mouse models need to be orthotopic -- Foreward: The future of patient-derived models of cancer. .
Physical Description:
XVI, 296 p. 60 illus., 50 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-57424-0
Publication Date:
2017.
Title:
Patient-Derived Mouse Models of Cancer Patient-Derived Orthotopic Xenografts (PDOX) / edited by Robert M. Hoffman.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
Hoffman, Robert M. editor.
SpringerLink (Online service)
General Notes:
In memorium: Jorgen Rygaard (1934-2016) Father of patient derived mouse models of cancer and modern cancer research -- The revival of patient-derived mouse models of cancer: way back to the future -- Patient-derived xenograft models for human cancer, The Freiburg experience -- From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype -- The Effects of the Organ Microenvironment on Metastatic-Cell Gene Signatures -- Techniques for surgical orthotopic implantation of human tumors to immunodeficient mice -- The first patient-derived orthotopic xenograft (PDOX) mouse models of cancer: Cancer of the colon, pancreas, lung, breast, ovary, and mesothelioma -- Patient-derived xenograft models of prostate cancer -- Patient-Derived Mouse Models of Sarcoma -- Cervical cancer patient-derived orthotopic xenograft (PDOX) models -- The use of pediatric patient-derived xenografts for identifying novel agents and combinations -- Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics -- Use of patient-derived orthotopic xenografts (PDOX) to evaluate transformative cancer therapeutics -- Fluorescent protein-expressing transgenic nude mice as hosts for patient tumors -- Fluorescence imaging of tumors in human patient-derived orthotopic xenograft (PDOX) mouse models: The iPDOX model -- The use of patient-derived orthotopic xenograft (PDOX) models to develop curative fluorescence-guided surgery of cancer.-Molecular characteristics of patient-derived tumor xenografts: genomic similarity to patient tumors and relevance for biomarker discovery -- Complementarity of patient-derived orthotopic xenografts (PDOX) models and molecular profiling for optimal therapy -- 3D Cell Culture Models -- Why patient derived mouse models need to be orthotopic -- Foreward: The future of patient-derived models of cancer. .
This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319574240
Subject:
Medicine.
Cancer research.
Oncology.
Medicine & Public Health.
Oncology.
Cancer research.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Contents:
In memorium: Jorgen Rygaard (1934-2016) Father of patient derived mouse models of cancer and modern cancer research -- The revival of patient-derived mouse models of cancer: way back to the future -- Patient-derived xenograft models for human cancer, The Freiburg experience -- From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype -- The Effects of the Organ Microenvironment on Metastatic-Cell Gene Signatures -- Techniques for surgical orthotopic implantation of human tumors to immunodeficient mice -- The first patient-derived orthotopic xenograft (PDOX) mouse models of cancer: Cancer of the colon, pancreas, lung, breast, ovary, and mesothelioma -- Patient-derived xenograft models of prostate cancer -- Patient-Derived Mouse Models of Sarcoma -- Cervical cancer patient-derived orthotopic xenograft (PDOX) models -- The use of pediatric patient-derived xenografts for identifying novel agents and combinations -- Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics -- Use of patient-derived orthotopic xenografts (PDOX) to evaluate transformative cancer therapeutics -- Fluorescent protein-expressing transgenic nude mice as hosts for patient tumors -- Fluorescence imaging of tumors in human patient-derived orthotopic xenograft (PDOX) mouse models: The iPDOX model -- The use of patient-derived orthotopic xenograft (PDOX) models to develop curative fluorescence-guided surgery of cancer.-Molecular characteristics of patient-derived tumor xenografts: genomic similarity to patient tumors and relevance for biomarker discovery -- Complementarity of patient-derived orthotopic xenografts (PDOX) models and molecular profiling for optimal therapy -- 3D Cell Culture Models -- Why patient derived mouse models need to be orthotopic -- Foreward: The future of patient-derived models of cancer. .
Physical Description:
XVI, 296 p. 60 illus., 50 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-57424-0
Publication Date:
2017.
Title:
Cell Therapy Current Status and Future Directions / edited by Dwaine F. Emerich, Gorka Orive.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
Emerich, Dwaine F. editor.
Orive, Gorka. editor.
SpringerLink (Online service)
General Notes:
Molecular Considerations in Cell Transplant Imaging -- Considerations for Successful Encapsulated β Cell Therapy -- Stem Cell Therapy for Neurovascular and Traumatic Brain Diseases -- Cell Replacement Strategies for Parkinson's Disease -- Cell Therapy for Epilepsy -- Dendritic Cell-Based Cancer Therapies: Current Status and Future Directions -- Encapsulation Approaches to Cell Therapy -- Biomaterials and Cells for Re-Vascularization -- Cell Reprogramming for Cardiac Regeneration and Rare Disease Modeling -- Engineering Organoid Systems to Model Health and Disease -- 3D Printing for Cell Therapy Applications -- Cell Therapy for Ophthalmic Diseases -- Cell Therapy: Approaching a Partnership with Pharma -- Stem Cell Therapy in Duchenne Muscular Dystrophy.
This volume provides a comprehensive, state-of-the art review of the field of cell therapy. The volume begins with an overview of the breadth of the field and then turns to overviews of imaging technologies that can aid in both safety and efficacy evaluations. The book then turns to numerous contributions detailing the rapidly growing field of stem cell therapies. These sections cover our understanding of the natural roles of stem cells in biology and human disease and then touches on several of the more prominent areas where stem cells are moving rapidly into clinical evaluation including neurodegenerative diseases, muscular dystrophy, cardiac repair, and diabetes. The volume concludes with contributions from experts in oncology, ophthalmiology, stem cells, 3-D printing, and biomaterials where the convergence of expertise is leading to unprecedented insights into how to minutely control the in vivo fate and function of transplanted and/or endogeneously mobilized cells. Finally, the book provides insights into the pivotal relationship between academic and industrial partnerships. This volume is designed to touch on the major areas where the field will make its greatest and most immediate clinical impacts. This text will provide a useful resource for physicians and researchers interested in the rapidly changing filed of cell therapy.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319571539
Subject:
Medicine.
Radiology.
Oncology.
Pathology.
Cell biology.
Medicine & Public Health.
Pathology.
Diagnostic Radiology.
Oncology.
Cell biology.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Contents:
Molecular Considerations in Cell Transplant Imaging -- Considerations for Successful Encapsulated β Cell Therapy -- Stem Cell Therapy for Neurovascular and Traumatic Brain Diseases -- Cell Replacement Strategies for Parkinson's Disease -- Cell Therapy for Epilepsy -- Dendritic Cell-Based Cancer Therapies: Current Status and Future Directions -- Encapsulation Approaches to Cell Therapy -- Biomaterials and Cells for Re-Vascularization -- Cell Reprogramming for Cardiac Regeneration and Rare Disease Modeling -- Engineering Organoid Systems to Model Health and Disease -- 3D Printing for Cell Therapy Applications -- Cell Therapy for Ophthalmic Diseases -- Cell Therapy: Approaching a Partnership with Pharma -- Stem Cell Therapy in Duchenne Muscular Dystrophy.
Physical Description:
XVI, 328 p. 59 illus., 49 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-57153-9
Publication Date:
2017.
Title:
Cell Therapy Current Status and Future Directions / edited by Dwaine F. Emerich, Gorka Orive.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
Emerich, Dwaine F. editor.
Orive, Gorka. editor.
SpringerLink (Online service)
General Notes:
Molecular Considerations in Cell Transplant Imaging -- Considerations for Successful Encapsulated β Cell Therapy -- Stem Cell Therapy for Neurovascular and Traumatic Brain Diseases -- Cell Replacement Strategies for Parkinson's Disease -- Cell Therapy for Epilepsy -- Dendritic Cell-Based Cancer Therapies: Current Status and Future Directions -- Encapsulation Approaches to Cell Therapy -- Biomaterials and Cells for Re-Vascularization -- Cell Reprogramming for Cardiac Regeneration and Rare Disease Modeling -- Engineering Organoid Systems to Model Health and Disease -- 3D Printing for Cell Therapy Applications -- Cell Therapy for Ophthalmic Diseases -- Cell Therapy: Approaching a Partnership with Pharma -- Stem Cell Therapy in Duchenne Muscular Dystrophy.
This volume provides a comprehensive, state-of-the art review of the field of cell therapy. The volume begins with an overview of the breadth of the field and then turns to overviews of imaging technologies that can aid in both safety and efficacy evaluations. The book then turns to numerous contributions detailing the rapidly growing field of stem cell therapies. These sections cover our understanding of the natural roles of stem cells in biology and human disease and then touches on several of the more prominent areas where stem cells are moving rapidly into clinical evaluation including neurodegenerative diseases, muscular dystrophy, cardiac repair, and diabetes. The volume concludes with contributions from experts in oncology, ophthalmiology, stem cells, 3-D printing, and biomaterials where the convergence of expertise is leading to unprecedented insights into how to minutely control the in vivo fate and function of transplanted and/or endogeneously mobilized cells. Finally, the book provides insights into the pivotal relationship between academic and industrial partnerships. This volume is designed to touch on the major areas where the field will make its greatest and most immediate clinical impacts. This text will provide a useful resource for physicians and researchers interested in the rapidly changing filed of cell therapy.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319571539
Subject:
Medicine.
Radiology.
Oncology.
Pathology.
Cell biology.
Medicine & Public Health.
Pathology.
Diagnostic Radiology.
Oncology.
Cell biology.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Contents:
Molecular Considerations in Cell Transplant Imaging -- Considerations for Successful Encapsulated β Cell Therapy -- Stem Cell Therapy for Neurovascular and Traumatic Brain Diseases -- Cell Replacement Strategies for Parkinson's Disease -- Cell Therapy for Epilepsy -- Dendritic Cell-Based Cancer Therapies: Current Status and Future Directions -- Encapsulation Approaches to Cell Therapy -- Biomaterials and Cells for Re-Vascularization -- Cell Reprogramming for Cardiac Regeneration and Rare Disease Modeling -- Engineering Organoid Systems to Model Health and Disease -- 3D Printing for Cell Therapy Applications -- Cell Therapy for Ophthalmic Diseases -- Cell Therapy: Approaching a Partnership with Pharma -- Stem Cell Therapy in Duchenne Muscular Dystrophy.
Physical Description:
XVI, 328 p. 59 illus., 49 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-57153-9
Publication Date:
2017.
Title:
Patient-Derived Xenograft Models of Human Cancer edited by Yuzhuo Wang, Dong Lin, Peter W. Gout.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
Wang, Yuzhuo. editor.
Lin, Dong. editor.
Gout, Peter W. editor.
SpringerLink (Online service)
General Notes:
Introduction -- History and Evolution of PDX Cancer Models -- Establishment and Characterization of PDX Models -- Methods of Generating PDX Models -- Fidelity and Stability of PDX Models -- Applications of PDX Models -- Studies of Cancer Heterogeneity -- PDX and Cancer Stem Cells -- Modeling Cancer Metastasis -- Modeling Drug Resistance -- PDX and Biomarker Development -- PDX and Preclinical Drug Screening -- Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine -- Epilogue -- Future Perspective.
This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319558257
Subject:
Medicine.
Oncology.
Medicine & Public Health.
Oncology.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Contents:
Introduction -- History and Evolution of PDX Cancer Models -- Establishment and Characterization of PDX Models -- Methods of Generating PDX Models -- Fidelity and Stability of PDX Models -- Applications of PDX Models -- Studies of Cancer Heterogeneity -- PDX and Cancer Stem Cells -- Modeling Cancer Metastasis -- Modeling Drug Resistance -- PDX and Biomarker Development -- PDX and Preclinical Drug Screening -- Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine -- Epilogue -- Future Perspective.
Physical Description:
XI, 204 p. 27 illus., 26 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-55825-7
Publication Date:
2017.
Title:
Patient-Derived Xenograft Models of Human Cancer edited by Yuzhuo Wang, Dong Lin, Peter W. Gout.
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Author:
Wang, Yuzhuo. editor.
Lin, Dong. editor.
Gout, Peter W. editor.
SpringerLink (Online service)
General Notes:
Introduction -- History and Evolution of PDX Cancer Models -- Establishment and Characterization of PDX Models -- Methods of Generating PDX Models -- Fidelity and Stability of PDX Models -- Applications of PDX Models -- Studies of Cancer Heterogeneity -- PDX and Cancer Stem Cells -- Modeling Cancer Metastasis -- Modeling Drug Resistance -- PDX and Biomarker Development -- PDX and Preclinical Drug Screening -- Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine -- Epilogue -- Future Perspective.
This book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field.
Publisher:
Springer International Publishing : Imprint: Humana Press,
Publication Place:
Cham :
ISBN:
9783319558257
Subject:
Medicine.
Oncology.
Medicine & Public Health.
Oncology.
Series:
Molecular and Translational Medicine,
Molecular and Translational Medicine,
Contents:
Introduction -- History and Evolution of PDX Cancer Models -- Establishment and Characterization of PDX Models -- Methods of Generating PDX Models -- Fidelity and Stability of PDX Models -- Applications of PDX Models -- Studies of Cancer Heterogeneity -- PDX and Cancer Stem Cells -- Modeling Cancer Metastasis -- Modeling Drug Resistance -- PDX and Biomarker Development -- PDX and Preclinical Drug Screening -- Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine -- Epilogue -- Future Perspective.
Physical Description:
XI, 204 p. 27 illus., 26 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-3-319-55825-7
Publication Date:
2017.
Title:
Molecular and Translational Vascular Medicine edited by Jonathon W. Homeister, Monte S. Willis.
Molecular and Translational Medicine
Molecular and Translational Medicine
Author:
Homeister, Jonathon W. editor.
Willis, Monte S. editor.
SpringerLink (Online service)
General Notes:
The Molecular Biology and Genetics of Aneurysms -- The Molecular Biology and Treatment of Systemic Vasculitis in Children -- Recent Insights into the Molecular and Cellular Contributions to Venous Thrombosis -- The Ubiquitin Proteasome System in Endothelial Cell Dysfunction and Vascular Disease -- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis -- Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions -- Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges -- Modulating the proliferative response to treat restenosis after vascular injury -- Cardiovascular Nanomedicine: Challenges and Opportunities -- Endothelial Progenitor Cells in the Treatment of Vascular Disease.
Molecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine. The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis. Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascular disease, endothelial progenitor cells for disease treatment, and the genetic basis of thoracic aortic aneurysms. Lastly, this volume includes sections on the newly emerging field of therapeutic angiogenesis, and the developing technology of nanoparticle-based imaging and therapeutic treatment of the diseased vasculature. All chapters are written by established experts in their fields, including pathologists, cardiovascular surgeons, and internists as well as translational biomedical researchers in a wide range of disciplines. While comprehensive, the material is presented in a manner that simplifies the complex pathophysiologic mechanisms that underlie common vascular diseases. Molecular and Translational Vascular Medicine will be of great value to a broad audience including internists, cardiovascular and vascular surgeons, pathologists, residents and fellows, as well as translational biomedical researchers.
Publisher:
Humana Press : Imprint: Humana Press,
Publication Place:
Totowa, NJ :
ISBN:
9781617799068
Subject:
Medicine.
Cardiology.
Pathology.
Medicine & Public Health.
Pathology.
Cardiology.
Molecular Medicine.
Series:
Molecular and Translational Medicine
Molecular and Translational Medicine
Contents:
The Molecular Biology and Genetics of Aneurysms -- The Molecular Biology and Treatment of Systemic Vasculitis in Children -- Recent Insights into the Molecular and Cellular Contributions to Venous Thrombosis -- The Ubiquitin Proteasome System in Endothelial Cell Dysfunction and Vascular Disease -- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis -- Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions -- Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges -- Modulating the proliferative response to treat restenosis after vascular injury -- Cardiovascular Nanomedicine: Challenges and Opportunities -- Endothelial Progenitor Cells in the Treatment of Vascular Disease.
Physical Description:
XIV, 335 p. 42 illus., 36 illus. in color. online resource.
Electronic Location:
http://dx.doi.org/10.1007/978-1-61779-906-8
Publication Date:
2012.
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